A causal account of the brain network computations underlying strategic social behavior
The authors show that transcranial magnetic disruption of the right temporoparietal junction decreases strategic behavior during competitive interactions. The altered behavior relates to neural activity changes both locally and in interconnected prefrontal areas. These brain networks may causally un...
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| Veröffentlicht in: | Nature neuroscience 2017-08, Vol.20 (8), p.1142-1149 |
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| creator | Hill, Christopher A Suzuki, Shinsuke Polania, Rafael Moisa, Marius O'Doherty, John P Ruff, Christian C |
| description | The authors show that transcranial magnetic disruption of the right temporoparietal junction decreases strategic behavior during competitive interactions. The altered behavior relates to neural activity changes both locally and in interconnected prefrontal areas. These brain networks may causally underlie the ability to predict the behavior of other agents.
During competitive interactions, humans have to estimate the impact of their own actions on their opponent's strategy. Here we provide evidence that neural computations in the right temporoparietal junction (rTPJ) and interconnected structures are causally involved in this process. By combining inhibitory continuous theta-burst transcranial magnetic stimulation with model-based functional MRI, we show that disrupting neural excitability in the rTPJ reduces behavioral and neural indices of mentalizing-related computations, as well as functional connectivity of the rTPJ with ventral and dorsal parts of the medial prefrontal cortex. These results provide a causal demonstration that neural computations instantiated in the rTPJ are neurobiological prerequisites for the ability to integrate opponent beliefs into strategic choice, through system-level interaction within the valuation and mentalizing networks. |
| doi_str_mv | 10.1038/nn.4602 |
| format | Article |
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During competitive interactions, humans have to estimate the impact of their own actions on their opponent's strategy. Here we provide evidence that neural computations in the right temporoparietal junction (rTPJ) and interconnected structures are causally involved in this process. By combining inhibitory continuous theta-burst transcranial magnetic stimulation with model-based functional MRI, we show that disrupting neural excitability in the rTPJ reduces behavioral and neural indices of mentalizing-related computations, as well as functional connectivity of the rTPJ with ventral and dorsal parts of the medial prefrontal cortex. These results provide a causal demonstration that neural computations instantiated in the rTPJ are neurobiological prerequisites for the ability to integrate opponent beliefs into strategic choice, through system-level interaction within the valuation and mentalizing networks.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn.4602</identifier><identifier>PMID: 28692061</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>59/36 ; 631/378/1595/2618 ; 631/378/2649/1409 ; 631/378/3919 ; Achievement tests ; Adolescent ; Adult ; Animal Genetics and Genomics ; Behavior ; Behavioral Sciences ; Biological Techniques ; Biomedicine ; Brain ; Brain - physiology ; Brain Mapping ; Brain research ; Business competition ; Competition ; Competition (Biology) ; Computer simulation ; Decision Making - physiology ; Excitability ; Female ; Functional magnetic resonance imaging ; Humans ; Influence ; Magnetic fields ; Magnetic Resonance Imaging - methods ; Male ; Neural circuitry ; Neural networks ; Neurobiology ; Neurosciences ; Physiological aspects ; Prefrontal cortex ; Psychological aspects ; Social Behavior ; Social organization ; Theory of Mind - physiology ; Transcranial magnetic stimulation ; Transcranial Magnetic Stimulation - methods ; Valuation ; Young Adult</subject><ispartof>Nature neuroscience, 2017-08, Vol.20 (8), p.1142-1149</ispartof><rights>Springer Nature America, Inc. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-6a0382f66816a6ca884ebb4bd4236ac30c4e986fcf1378e91b120ea918c6d8753</citedby><cites>FETCH-LOGICAL-c509t-6a0382f66816a6ca884ebb4bd4236ac30c4e986fcf1378e91b120ea918c6d8753</cites><orcidid>0000-0001-9931-0831 ; 0000-0002-3964-2364</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn.4602$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn.4602$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28692061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hill, Christopher A</creatorcontrib><creatorcontrib>Suzuki, Shinsuke</creatorcontrib><creatorcontrib>Polania, Rafael</creatorcontrib><creatorcontrib>Moisa, Marius</creatorcontrib><creatorcontrib>O'Doherty, John P</creatorcontrib><creatorcontrib>Ruff, Christian C</creatorcontrib><title>A causal account of the brain network computations underlying strategic social behavior</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>The authors show that transcranial magnetic disruption of the right temporoparietal junction decreases strategic behavior during competitive interactions. The altered behavior relates to neural activity changes both locally and in interconnected prefrontal areas. These brain networks may causally underlie the ability to predict the behavior of other agents.
During competitive interactions, humans have to estimate the impact of their own actions on their opponent's strategy. Here we provide evidence that neural computations in the right temporoparietal junction (rTPJ) and interconnected structures are causally involved in this process. By combining inhibitory continuous theta-burst transcranial magnetic stimulation with model-based functional MRI, we show that disrupting neural excitability in the rTPJ reduces behavioral and neural indices of mentalizing-related computations, as well as functional connectivity of the rTPJ with ventral and dorsal parts of the medial prefrontal cortex. 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Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hill, Christopher A</au><au>Suzuki, Shinsuke</au><au>Polania, Rafael</au><au>Moisa, Marius</au><au>O'Doherty, John P</au><au>Ruff, Christian C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A causal account of the brain network computations underlying strategic social behavior</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>20</volume><issue>8</issue><spage>1142</spage><epage>1149</epage><pages>1142-1149</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><abstract>The authors show that transcranial magnetic disruption of the right temporoparietal junction decreases strategic behavior during competitive interactions. The altered behavior relates to neural activity changes both locally and in interconnected prefrontal areas. These brain networks may causally underlie the ability to predict the behavior of other agents.
During competitive interactions, humans have to estimate the impact of their own actions on their opponent's strategy. Here we provide evidence that neural computations in the right temporoparietal junction (rTPJ) and interconnected structures are causally involved in this process. By combining inhibitory continuous theta-burst transcranial magnetic stimulation with model-based functional MRI, we show that disrupting neural excitability in the rTPJ reduces behavioral and neural indices of mentalizing-related computations, as well as functional connectivity of the rTPJ with ventral and dorsal parts of the medial prefrontal cortex. These results provide a causal demonstration that neural computations instantiated in the rTPJ are neurobiological prerequisites for the ability to integrate opponent beliefs into strategic choice, through system-level interaction within the valuation and mentalizing networks.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28692061</pmid><doi>10.1038/nn.4602</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9931-0831</orcidid><orcidid>https://orcid.org/0000-0002-3964-2364</orcidid></addata></record> |
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| subjects | 59/36 631/378/1595/2618 631/378/2649/1409 631/378/3919 Achievement tests Adolescent Adult Animal Genetics and Genomics Behavior Behavioral Sciences Biological Techniques Biomedicine Brain Brain - physiology Brain Mapping Brain research Business competition Competition Competition (Biology) Computer simulation Decision Making - physiology Excitability Female Functional magnetic resonance imaging Humans Influence Magnetic fields Magnetic Resonance Imaging - methods Male Neural circuitry Neural networks Neurobiology Neurosciences Physiological aspects Prefrontal cortex Psychological aspects Social Behavior Social organization Theory of Mind - physiology Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Valuation Young Adult |
| title | A causal account of the brain network computations underlying strategic social behavior |
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