Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

In a rat model of hydrocephalus triggered by intraventricular hemorrhage, Kristopher Kahle and colleagues show that TLR4–NF-κB-dependent inflammatory signaling in the choroid plexus causes hypersecretion of cerebrospinal fluid that drives hydrocephalus. Targeting TLR4–NF-κB-mediated signaling or the...

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Veröffentlicht in:	Nature medicine 2017-08, Vol.23 (8), p.997-1003
Hauptverfasser:	Karimy, Jason K, Zhang, Jinwei, Kurland, David B, Theriault, Brianna Carusillo, Duran, Daniel, Stokum, Jesse A, Furey, Charuta Gavankar, Zhou, Xu, Mansuri, M Shahid, Montejo, Julio, Vera, Alberto, DiLuna, Michael L, Delpire, Eric, Alper, Seth L, Gunel, Murat, Gerzanich, Volodymyr, Medzhitov, Ruslan, Simard, J Marc, Kahle, Kristopher T
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/2609 631/378/371 692/308/575 692/617/375/240 82 82/51 82/80 Acetazolamide - pharmacology Animals Antioxidants - pharmacology Biomedicine Blotting, Western Brain Bumetanide Bumetanide - pharmacology Cancer Research Causes of Central nervous system Cerebral Hemorrhage - complications Cerebral Hemorrhage - immunology Cerebral Ventricles Cerebrospinal fluid Cerebrospinal Fluid - secretion Chloride transport Choroid plexus Choroid Plexus - drug effects Choroid Plexus - immunology Choroid Plexus - secretion Development and progression Diuretics - pharmacology Epithelium Gene Knockdown Techniques Gene Knockout Techniques Health aspects Hemorrhage Homeostasis Hydrocephalus Hydrocephalus - etiology Hydrocephalus - immunology Hydrocephalus - metabolism Immune system Immunoblotting Immunohistochemistry Immunoprecipitation Immunosuppressive agents Infectious Diseases Inflammation Inflammatory response letter Medicine Metabolic Diseases Molecular Medicine Neurosciences Neurosurgery NF-kappa B - immunology NF-κB protein Pathogenesis Physiological aspects Physiology Proline - analogs & derivatives Proline - pharmacology Protein-Serine-Threonine Kinases - metabolism Proteins Rats Rats, Wistar Reabsorption Regulatory agencies Rodents Salicylanilides - pharmacology Solute Carrier Family 12, Member 2 - metabolism Sulfonamides - pharmacology Thiocarbamates - pharmacology TLR4 TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Toll-like receptors Transcription factors Tumor necrosis factor-TNF Ventricles (cerebral)
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