Gastric bypass simultaneously improves adipose tissue function and insulin-dependent type 2 diabetes mellitus

Objective The underlying causes of type 2 diabetes (T2DM) remain poorly understood. Adipose tissue dysfunction with high leptin, inflammation, and increased oxidative stress may play a pivotal role in T2DM development in obese patients. Little is known about the changes in the adipose tissue after R...

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Veröffentlicht in:	Langenbeck's archives of surgery 2017-09, Vol.402 (6), p.901-910
Hauptverfasser:	Billeter, Adrian T., Vittas, Spiros, Israel, Barbara, Scheurlen, Katharina M., Hidmark, Asa, Fleming, Thomas H., Kopf, Stefan, Büchler, Markus W., Müller-Stich, Beat P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Adipose Tissue - metabolism Adult Body Mass Index Cardiac Surgery Cohort Studies Comorbidity Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - epidemiology Female Follow-Up Studies Gastric Bypass - methods General Surgery Humans Insulin - therapeutic use Insulin Resistance Male Medicine Medicine & Public Health Middle Aged Obesity, Morbid - diagnosis Obesity, Morbid - epidemiology Obesity, Morbid - surgery Original Article Oxidative Stress - physiology Prospective Studies Risk Assessment Thoracic Surgery Traumatic Surgery Treatment Outcome Vascular Surgery Weight Loss - physiology
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Beschreibung
Zusammenfassung:	Objective The underlying causes of type 2 diabetes (T2DM) remain poorly understood. Adipose tissue dysfunction with high leptin, inflammation, and increased oxidative stress may play a pivotal role in T2DM development in obese patients. Little is known about the changes in the adipose tissue after Roux-Y gastric bypass (RYGB) in non-severely obese patients (BMI
ISSN:	1435-2443 1435-2451
DOI:	10.1007/s00423-017-1601-x