Dual function of Lactobacillus kefiri DH5 in preventing high‐fat‐diet‐induced obesity: direct reduction of cholesterol and upregulation of PPAR‐α in adipose tissue

Scope Kefir consumption inhibits the development of obesity and non‐alcoholic fatty liver disease (NALFD) in mice fed 60% high‐fat diet (HFD). To identify the key contributor of this effect, we isolated lactic acid bacteria (LAB) from kefir and examined their anti‐obesity properties from in vitro sc...

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Veröffentlicht in:	Molecular nutrition & food research 2017-11, Vol.61 (11), p.n/a
Hauptverfasser:	Kim, Dong‐Hyeon, Jeong, Dana, Kang, Il‐Byeong, Kim, Hyunsook, Song, Kwang‐Young, Seo, Kun‐Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue, White - enzymology Adipose Tissue, White - metabolism Adipose Tissue, White - pathology Adiposity Animals Bacteria Body weight Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism Cholesterol Cholesterol reduction Cholesterol, Dietary - adverse effects Cholesterol, Dietary - metabolism Diet, High-Fat - adverse effects Direct reduction Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Fatty liver Feces - chemistry Feces - microbiology Gene Expression Regulation High fat diet Hypercholesterolemia - metabolism Hypercholesterolemia - microbiology Hypercholesterolemia - pathology Hypercholesterolemia - prevention & control In vivo methods and tests Intestinal microflora Kefir Kefir - microbiology Lactic acid Lactic acid bacteria Lactobacillus Lactobacillus - classification Lactobacillus - growth & development Lactobacillus - isolation & purification Lactobacillus - metabolism Lactobacillus kefiri Liver Liver diseases Low density lipoprotein Male Mice Mice, Inbred C57BL Microbial Viability Molecular Typing Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - microbiology Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - prevention & control Obesity Obesity - metabolism Obesity - microbiology Obesity - pathology Obesity - prevention & control Oxidation Peroxisome proliferator-activated receptors PPAR alpha - genetics PPAR alpha - metabolism PPAR‐α Probiotics - therapeutic use Random Allocation Republic of Korea Rodents Steatosis Survivability Up-regulation
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