Comparison of 12-Hour with 72-Hour Terlipressin Therapy for Bleeding Esophageal Varices
To determine the efficacy of 12-hour of Terlipressin therapy as compared to 72-hour therapy in preventing rebleeding after endoscopic therapy. Interventional study. Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from January to March 2016. Cirrhotic patients presenting...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2017-06, Vol.27 (6), p.334-337 |
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| container_title | Journal of the College of Physicians and Surgeons--Pakistan |
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| creator | Salim, Adnan Malik, Kashif Haq, Israr Ul Butt, Arshad Kamal Alam, Altaf |
| description | To determine the efficacy of 12-hour of Terlipressin therapy as compared to 72-hour therapy in preventing rebleeding after endoscopic therapy.
Interventional study.
Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from January to March 2016.
Cirrhotic patients presenting to our hospital with GI (gastrointestinal) bleeding received Terlipressin 2 mg intravenous bolus, followed by 1mg 6-hourly until undergoing endoscopy. Those with esophageal varices as the source of bleeding underwent band ligation and were recruited. Of the 93 enrolled patients, 90 remained and were randomized into 25 (27.8%) in control Group-Aand 65 (72.2%) in test Group-B. Group-Areceived 72-hour of Terlipressin while Group-B received it for 12-hour. Both groups were monitored for rebleeding for 5 days.
Rebleeding occurred in 1 (4%) patient in Group-Aand 3 (4.6%) in Group-B during the 5-day period. All 4 (4.4%) underwent repeat endoscopy. The Group-Apatient and 2 (3%) of 3 Group-B patients showed ulcers over band ligation sites as source of bleed. The third Group-B patient showed varices requiring repeat banding. One (4%) patient (Group-A) died due to persistent encephalopathy. No drug related adverse effects were seen.
A12-hour duration of Terlipressin as an adjunct to endoscopic band ligation shows similar results to 72-hour therapy. |
| format | Article |
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Interventional study.
Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from January to March 2016.
Cirrhotic patients presenting to our hospital with GI (gastrointestinal) bleeding received Terlipressin 2 mg intravenous bolus, followed by 1mg 6-hourly until undergoing endoscopy. Those with esophageal varices as the source of bleeding underwent band ligation and were recruited. Of the 93 enrolled patients, 90 remained and were randomized into 25 (27.8%) in control Group-Aand 65 (72.2%) in test Group-B. Group-Areceived 72-hour of Terlipressin while Group-B received it for 12-hour. Both groups were monitored for rebleeding for 5 days.
Rebleeding occurred in 1 (4%) patient in Group-Aand 3 (4.6%) in Group-B during the 5-day period. All 4 (4.4%) underwent repeat endoscopy. The Group-Apatient and 2 (3%) of 3 Group-B patients showed ulcers over band ligation sites as source of bleed. The third Group-B patient showed varices requiring repeat banding. One (4%) patient (Group-A) died due to persistent encephalopathy. No drug related adverse effects were seen.
A12-hour duration of Terlipressin as an adjunct to endoscopic band ligation shows similar results to 72-hour therapy.</description><identifier>ISSN: 1022-386X</identifier><identifier>EISSN: 1681-7168</identifier><identifier>PMID: 28689520</identifier><language>eng</language><publisher>Pakistan: College of Physicians and Surgeons Pakistan</publisher><subject>Adult ; Aged ; Analysis ; Care and treatment ; Combined Modality Therapy ; Comparative analysis ; Complications and side effects ; Dosage and administration ; Drug Administration Schedule ; Drug therapy ; Endoscopy ; Endoscopy - methods ; Esophageal and Gastric Varices - complications ; Esophageal and Gastric Varices - therapy ; Esophageal varices ; Female ; Gastrointestinal Hemorrhage - etiology ; Gastrointestinal Hemorrhage - prevention & control ; Gastrointestinal Hemorrhage - therapy ; Hemorrhage ; Humans ; Ligation ; Liver Cirrhosis - complications ; Lypressin - analogs & derivatives ; Lypressin - therapeutic use ; Male ; Middle Aged ; Prevention ; Terlipressin ; Time Factors ; Treatment Outcome ; Vasoconstrictor Agents - therapeutic use</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2017-06, Vol.27 (6), p.334-337</ispartof><rights>COPYRIGHT 2017 College of Physicians and Surgeons Pakistan</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28689520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salim, Adnan</creatorcontrib><creatorcontrib>Malik, Kashif</creatorcontrib><creatorcontrib>Haq, Israr Ul</creatorcontrib><creatorcontrib>Butt, Arshad Kamal</creatorcontrib><creatorcontrib>Alam, Altaf</creatorcontrib><title>Comparison of 12-Hour with 72-Hour Terlipressin Therapy for Bleeding Esophageal Varices</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>J Coll Physicians Surg Pak</addtitle><description>To determine the efficacy of 12-hour of Terlipressin therapy as compared to 72-hour therapy in preventing rebleeding after endoscopic therapy.
Interventional study.
Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from January to March 2016.
Cirrhotic patients presenting to our hospital with GI (gastrointestinal) bleeding received Terlipressin 2 mg intravenous bolus, followed by 1mg 6-hourly until undergoing endoscopy. Those with esophageal varices as the source of bleeding underwent band ligation and were recruited. Of the 93 enrolled patients, 90 remained and were randomized into 25 (27.8%) in control Group-Aand 65 (72.2%) in test Group-B. Group-Areceived 72-hour of Terlipressin while Group-B received it for 12-hour. Both groups were monitored for rebleeding for 5 days.
Rebleeding occurred in 1 (4%) patient in Group-Aand 3 (4.6%) in Group-B during the 5-day period. All 4 (4.4%) underwent repeat endoscopy. The Group-Apatient and 2 (3%) of 3 Group-B patients showed ulcers over band ligation sites as source of bleed. The third Group-B patient showed varices requiring repeat banding. One (4%) patient (Group-A) died due to persistent encephalopathy. No drug related adverse effects were seen.
A12-hour duration of Terlipressin as an adjunct to endoscopic band ligation shows similar results to 72-hour therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Care and treatment</subject><subject>Combined Modality Therapy</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Dosage and administration</subject><subject>Drug Administration Schedule</subject><subject>Drug therapy</subject><subject>Endoscopy</subject><subject>Endoscopy - methods</subject><subject>Esophageal and Gastric Varices - complications</subject><subject>Esophageal and Gastric Varices - therapy</subject><subject>Esophageal varices</subject><subject>Female</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>Gastrointestinal Hemorrhage - prevention & control</subject><subject>Gastrointestinal Hemorrhage - therapy</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Ligation</subject><subject>Liver Cirrhosis - complications</subject><subject>Lypressin - analogs & derivatives</subject><subject>Lypressin - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevention</subject><subject>Terlipressin</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vasoconstrictor Agents - therapeutic use</subject><issn>1022-386X</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkF1LwzAUhosobk7_ggS88aaSpE2aXM4xnTDwpn7clTQ96SJtU5MW2b-3snkhyIHzxfO-HM5JNCdckDib8unUY0rjRPD3WXQRwgfGCSNCnEczKriQjOJ59LZyba-8Da5DziBC440bPfqyww5lxyEH39jeQwi2Q_kOvOr3yDiP7huAynY1WgfX71QNqkGvk5mGcBmdGdUEuDrWRfTysM5Xm3j7_Pi0Wm7jmmZiiJkRBqRkTHGuNU45qCpVRFJISClJaojgQLNUlpkUhlUlKRVooRljRqWGJovo9uDbe_c5QhiK1gYNTaM6cGMoiCQZ55SneEJvDmitGihsZ9zglf7BiyXDmEjBGJ-ou3-oKSporXYdGDvt_wiujxeMZQtV0XvbKr8vfn-cfAPecHcS</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Salim, Adnan</creator><creator>Malik, Kashif</creator><creator>Haq, Israr Ul</creator><creator>Butt, Arshad Kamal</creator><creator>Alam, Altaf</creator><general>College of Physicians and Surgeons Pakistan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Comparison of 12-Hour with 72-Hour Terlipressin Therapy for Bleeding Esophageal Varices</title><author>Salim, Adnan ; Malik, Kashif ; Haq, Israr Ul ; Butt, Arshad Kamal ; Alam, Altaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-5f8fe9955a66cc046ead4a192e31b914f186e2749b798f5db1baec8c555fa4f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Care and treatment</topic><topic>Combined Modality Therapy</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Dosage and administration</topic><topic>Drug Administration Schedule</topic><topic>Drug therapy</topic><topic>Endoscopy</topic><topic>Endoscopy - methods</topic><topic>Esophageal and Gastric Varices - complications</topic><topic>Esophageal and Gastric Varices - therapy</topic><topic>Esophageal varices</topic><topic>Female</topic><topic>Gastrointestinal Hemorrhage - etiology</topic><topic>Gastrointestinal Hemorrhage - prevention & control</topic><topic>Gastrointestinal Hemorrhage - therapy</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Ligation</topic><topic>Liver Cirrhosis - complications</topic><topic>Lypressin - analogs & derivatives</topic><topic>Lypressin - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevention</topic><topic>Terlipressin</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vasoconstrictor Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salim, Adnan</creatorcontrib><creatorcontrib>Malik, Kashif</creatorcontrib><creatorcontrib>Haq, Israr Ul</creatorcontrib><creatorcontrib>Butt, Arshad Kamal</creatorcontrib><creatorcontrib>Alam, Altaf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salim, Adnan</au><au>Malik, Kashif</au><au>Haq, Israr Ul</au><au>Butt, Arshad Kamal</au><au>Alam, Altaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of 12-Hour with 72-Hour Terlipressin Therapy for Bleeding Esophageal Varices</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2017-06</date><risdate>2017</risdate><volume>27</volume><issue>6</issue><spage>334</spage><epage>337</epage><pages>334-337</pages><issn>1022-386X</issn><eissn>1681-7168</eissn><abstract>To determine the efficacy of 12-hour of Terlipressin therapy as compared to 72-hour therapy in preventing rebleeding after endoscopic therapy.
Interventional study.
Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from January to March 2016.
Cirrhotic patients presenting to our hospital with GI (gastrointestinal) bleeding received Terlipressin 2 mg intravenous bolus, followed by 1mg 6-hourly until undergoing endoscopy. Those with esophageal varices as the source of bleeding underwent band ligation and were recruited. Of the 93 enrolled patients, 90 remained and were randomized into 25 (27.8%) in control Group-Aand 65 (72.2%) in test Group-B. Group-Areceived 72-hour of Terlipressin while Group-B received it for 12-hour. Both groups were monitored for rebleeding for 5 days.
Rebleeding occurred in 1 (4%) patient in Group-Aand 3 (4.6%) in Group-B during the 5-day period. All 4 (4.4%) underwent repeat endoscopy. The Group-Apatient and 2 (3%) of 3 Group-B patients showed ulcers over band ligation sites as source of bleed. The third Group-B patient showed varices requiring repeat banding. One (4%) patient (Group-A) died due to persistent encephalopathy. No drug related adverse effects were seen.
A12-hour duration of Terlipressin as an adjunct to endoscopic band ligation shows similar results to 72-hour therapy.</abstract><cop>Pakistan</cop><pub>College of Physicians and Surgeons Pakistan</pub><pmid>28689520</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1022-386X |
| ispartof | Journal of the College of Physicians and Surgeons--Pakistan, 2017-06, Vol.27 (6), p.334-337 |
| issn | 1022-386X 1681-7168 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Analysis Care and treatment Combined Modality Therapy Comparative analysis Complications and side effects Dosage and administration Drug Administration Schedule Drug therapy Endoscopy Endoscopy - methods Esophageal and Gastric Varices - complications Esophageal and Gastric Varices - therapy Esophageal varices Female Gastrointestinal Hemorrhage - etiology Gastrointestinal Hemorrhage - prevention & control Gastrointestinal Hemorrhage - therapy Hemorrhage Humans Ligation Liver Cirrhosis - complications Lypressin - analogs & derivatives Lypressin - therapeutic use Male Middle Aged Prevention Terlipressin Time Factors Treatment Outcome Vasoconstrictor Agents - therapeutic use |
| title | Comparison of 12-Hour with 72-Hour Terlipressin Therapy for Bleeding Esophageal Varices |
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