The synergistic effects of NGF and IGF‐1 on neurite growth in adult sensory neurons: convergence on the PI 3‐kinase signaling pathway

Nerve growth factor (NGF) and insulin‐like growth factor‐1 (IGF‐1) play an important role in promoting axonal growth from dorsal root ganglion (DRG) neurons. Adult DRG neurons exhibit neurotrophin‐independent survival, providing an excellent system with which to study trophic factor effects on neuri...

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Veröffentlicht in:	Journal of neurochemistry 2003-09, Vol.86 (5), p.1116-1128
Hauptverfasser:	Jones, David M., Tucker, Budd A., Rahimtula, Masuma, Mearow, Karen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	adult sensory neurons Animals Biochemistry and metabolism Biological and medical sciences Blotting, Western Central nervous system Drug Synergism Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology glycogen synthase kinase Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Insulin-Like Growth Factor I - pharmacology insulin‐like growth factor‐1 mitogen activated protein kinase Mitogen-Activated Protein Kinases - metabolism nerve growth factor Nerve Growth Factor - pharmacology Neurites - drug effects Neurites - physiology Neurons, Afferent - cytology Neurons, Afferent - drug effects Neurons, Afferent - metabolism Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism phosphoinositide 3‐kinase Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology Vertebrates: nervous system and sense organs
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