High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece
Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We i...
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| Veröffentlicht in: | European child & adolescent psychiatry 2018-01, Vol.27 (1), p.79-88 |
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| creator | Daraki, Vasiliki Roumeliotaki, Theano Koutra, Katerina Chalkiadaki, Georgia Katrinaki, Marianna Kyriklaki, Andriani Kampouri, Mariza Margetaki, Katerina Vafeiadi, Marina Papavasiliou, Stathis Kogevinas, Manolis Chatzi, Leda |
| description | Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother–child pairs from the prospective pregnancy cohort, “Rhea” in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children’s Abilities. Behavioral difficulties were assessed by means of Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Children of women in the high 25(OH) D tertile (>50.7 nmol/l) had 37% decreased number of hyperactivity–impulsivity symptoms (IRR 0.63, 95% CI 0.39, 0.99,
p
trend
= 0.05) and 40% decreased number of total ADHD-like symptoms (IRR 0.60, 95% CI 0.37, 0.95,
p
trend
= 0.03) at 4 years of age, compared to children of women in the low 25(OH) D tertile ( |
| doi_str_mv | 10.1007/s00787-017-1023-x |
| format | Article |
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p
trend
= 0.05) and 40% decreased number of total ADHD-like symptoms (IRR 0.60, 95% CI 0.37, 0.95,
p
trend
= 0.03) at 4 years of age, compared to children of women in the low 25(OH) D tertile (<38.4 nmol/l), after adjustment for several confounders. Similar associations were found with the hyperactivity/inattention score of the SDQ questionnaire. Children of mothers with high 25(OH) D levels had also fewer total behavioral difficulties (beta-coeff: −1.25, 95% CI −2.32, −0.19) and externalizing symptoms (beta-coeff: −0.87, 95% CI −1.58, −0.15) at preschool age. The observed associations were stronger in girls than in boys (
p
for interaction
< 0.1). No association was observed between maternal 25(OH) D concentrations and cognitive function in preschoolers. Our results suggest that high maternal vitamin D levels in early pregnancy may protect against behavioral difficulties, especially ADHD-like symptoms at preschool age.</description><identifier>ISSN: 1018-8827</identifier><identifier>EISSN: 1435-165X</identifier><identifier>DOI: 10.1007/s00787-017-1023-x</identifier><identifier>PMID: 28685401</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>25-Hydroxyvitamin D ; Adult ; Age ; Animals ; Associations ; Attention deficit hyperactivity disorder ; Behavior ; Brain ; Brain - physiopathology ; Child ; Child & adolescent psychiatry ; Child and Adolescent Psychiatry ; Child, Preschool ; Children ; Cognitive ability ; Cognitive functioning ; Cohort Studies ; Female ; Fetuses ; Greece ; Humans ; Hyperactivity ; Impulsive behavior ; Impulsivity ; Male ; Maternal serum ; Medicine ; Medicine & Public Health ; Mother-child relations ; Mothers - psychology ; Original Contribution ; Pregnancy ; Prenatal care ; Preschool children ; Prospective Studies ; Protective factors ; Psychiatry ; Questionnaires ; Serum ; Vitamin D ; Vitamin D - therapeutic use ; Women</subject><ispartof>European child & adolescent psychiatry, 2018-01, Vol.27 (1), p.79-88</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>European Child & Adolescent Psychiatry is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ecce8c559e9756b52eb22d5fb8248a00b29831124627bfe72704939c494ce6c13</citedby><cites>FETCH-LOGICAL-c438t-ecce8c559e9756b52eb22d5fb8248a00b29831124627bfe72704939c494ce6c13</cites><orcidid>0000-0003-1764-4913</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00787-017-1023-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00787-017-1023-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,12825,27901,27902,30976,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28685401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daraki, Vasiliki</creatorcontrib><creatorcontrib>Roumeliotaki, Theano</creatorcontrib><creatorcontrib>Koutra, Katerina</creatorcontrib><creatorcontrib>Chalkiadaki, Georgia</creatorcontrib><creatorcontrib>Katrinaki, Marianna</creatorcontrib><creatorcontrib>Kyriklaki, Andriani</creatorcontrib><creatorcontrib>Kampouri, Mariza</creatorcontrib><creatorcontrib>Margetaki, Katerina</creatorcontrib><creatorcontrib>Vafeiadi, Marina</creatorcontrib><creatorcontrib>Papavasiliou, Stathis</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Chatzi, Leda</creatorcontrib><title>High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece</title><title>European child & adolescent psychiatry</title><addtitle>Eur Child Adolesc Psychiatry</addtitle><addtitle>Eur Child Adolesc Psychiatry</addtitle><description>Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother–child pairs from the prospective pregnancy cohort, “Rhea” in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children’s Abilities. Behavioral difficulties were assessed by means of Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Children of women in the high 25(OH) D tertile (>50.7 nmol/l) had 37% decreased number of hyperactivity–impulsivity symptoms (IRR 0.63, 95% CI 0.39, 0.99,
p
trend
= 0.05) and 40% decreased number of total ADHD-like symptoms (IRR 0.60, 95% CI 0.37, 0.95,
p
trend
= 0.03) at 4 years of age, compared to children of women in the low 25(OH) D tertile (<38.4 nmol/l), after adjustment for several confounders. Similar associations were found with the hyperactivity/inattention score of the SDQ questionnaire. Children of mothers with high 25(OH) D levels had also fewer total behavioral difficulties (beta-coeff: −1.25, 95% CI −2.32, −0.19) and externalizing symptoms (beta-coeff: −0.87, 95% CI −1.58, −0.15) at preschool age. The observed associations were stronger in girls than in boys (
p
for interaction
< 0.1). No association was observed between maternal 25(OH) D concentrations and cognitive function in preschoolers. Our results suggest that high maternal vitamin D levels in early pregnancy may protect against behavioral difficulties, especially ADHD-like symptoms at preschool age.</description><subject>25-Hydroxyvitamin D</subject><subject>Adult</subject><subject>Age</subject><subject>Animals</subject><subject>Associations</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Behavior</subject><subject>Brain</subject><subject>Brain - physiopathology</subject><subject>Child</subject><subject>Child & adolescent psychiatry</subject><subject>Child and Adolescent Psychiatry</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Cognitive functioning</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fetuses</subject><subject>Greece</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Impulsive behavior</subject><subject>Impulsivity</subject><subject>Male</subject><subject>Maternal serum</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mother-child relations</subject><subject>Mothers - psychology</subject><subject>Original Contribution</subject><subject>Pregnancy</subject><subject>Prenatal care</subject><subject>Preschool children</subject><subject>Prospective Studies</subject><subject>Protective factors</subject><subject>Psychiatry</subject><subject>Questionnaires</subject><subject>Serum</subject><subject>Vitamin D</subject><subject>Vitamin D - therapeutic use</subject><subject>Women</subject><issn>1018-8827</issn><issn>1435-165X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc9qFTEYxYNY7B99ADcScOOio0kmmSTuyrW2QkEQBXdDJvebOymZSU0yl95d36FrX65PYoZbRQQ3yQn5nfORHIReUvKWEiLfpbIoWREqK0pYXd0-QUeU16Kijfj-tGhCVaUUk4foOKVrQqjQhD1Dh0w1SnBCj9DPS7cZ8GgyxMl4vHXZjG7CH7CHLfiEiwYT_Q7fRNhMZrK7Ai-nkMFmbDbGTSnjDgazdSGWiLXre2dnnx0kbPJiTHYIwRcY3uM8AP4ygMFjKDI-3N3bwfk1tmEIMZ_iVYQMp_giAlh4jg564xO8eNxP0LeP519Xl9XV54tPq7OryvJa5QqsBWWF0KClaDrBoGNsLfpOMa4MIR3TqqaU8YbJrgfJJOG61pZrbqGxtD5Bb_a55V0_Zki5HV2y4L2ZIMyppZrKuhFU64K-_ge9DvPydwulOVNcy6ZQdE_ZGFKK0Lc30Y0m7lpK2qW7dt9dW7prl-7a2-J59Zg8dyOs_zh-l1UAtgdSuZo2EP8a_d_UX29jpxw</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Daraki, Vasiliki</creator><creator>Roumeliotaki, Theano</creator><creator>Koutra, Katerina</creator><creator>Chalkiadaki, Georgia</creator><creator>Katrinaki, Marianna</creator><creator>Kyriklaki, Andriani</creator><creator>Kampouri, Mariza</creator><creator>Margetaki, Katerina</creator><creator>Vafeiadi, Marina</creator><creator>Papavasiliou, Stathis</creator><creator>Kogevinas, Manolis</creator><creator>Chatzi, Leda</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1764-4913</orcidid></search><sort><creationdate>20180101</creationdate><title>High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece</title><author>Daraki, Vasiliki ; Roumeliotaki, Theano ; Koutra, Katerina ; Chalkiadaki, Georgia ; Katrinaki, Marianna ; Kyriklaki, Andriani ; Kampouri, Mariza ; Margetaki, Katerina ; Vafeiadi, Marina ; Papavasiliou, Stathis ; Kogevinas, Manolis ; Chatzi, Leda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-ecce8c559e9756b52eb22d5fb8248a00b29831124627bfe72704939c494ce6c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adult</topic><topic>Age</topic><topic>Animals</topic><topic>Associations</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Behavior</topic><topic>Brain</topic><topic>Brain - physiopathology</topic><topic>Child</topic><topic>Child & adolescent psychiatry</topic><topic>Child and Adolescent Psychiatry</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Cognitive functioning</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fetuses</topic><topic>Greece</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Impulsive behavior</topic><topic>Impulsivity</topic><topic>Male</topic><topic>Maternal serum</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mother-child relations</topic><topic>Mothers - psychology</topic><topic>Original Contribution</topic><topic>Pregnancy</topic><topic>Prenatal care</topic><topic>Preschool children</topic><topic>Prospective Studies</topic><topic>Protective factors</topic><topic>Psychiatry</topic><topic>Questionnaires</topic><topic>Serum</topic><topic>Vitamin D</topic><topic>Vitamin D - therapeutic use</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daraki, Vasiliki</creatorcontrib><creatorcontrib>Roumeliotaki, Theano</creatorcontrib><creatorcontrib>Koutra, Katerina</creatorcontrib><creatorcontrib>Chalkiadaki, Georgia</creatorcontrib><creatorcontrib>Katrinaki, Marianna</creatorcontrib><creatorcontrib>Kyriklaki, Andriani</creatorcontrib><creatorcontrib>Kampouri, Mariza</creatorcontrib><creatorcontrib>Margetaki, Katerina</creatorcontrib><creatorcontrib>Vafeiadi, Marina</creatorcontrib><creatorcontrib>Papavasiliou, Stathis</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Chatzi, Leda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European child & adolescent psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daraki, Vasiliki</au><au>Roumeliotaki, Theano</au><au>Koutra, Katerina</au><au>Chalkiadaki, Georgia</au><au>Katrinaki, Marianna</au><au>Kyriklaki, Andriani</au><au>Kampouri, Mariza</au><au>Margetaki, Katerina</au><au>Vafeiadi, Marina</au><au>Papavasiliou, Stathis</au><au>Kogevinas, Manolis</au><au>Chatzi, Leda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece</atitle><jtitle>European child & adolescent psychiatry</jtitle><stitle>Eur Child Adolesc Psychiatry</stitle><addtitle>Eur Child Adolesc Psychiatry</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>27</volume><issue>1</issue><spage>79</spage><epage>88</epage><pages>79-88</pages><issn>1018-8827</issn><eissn>1435-165X</eissn><abstract>Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother–child pairs from the prospective pregnancy cohort, “Rhea” in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children’s Abilities. Behavioral difficulties were assessed by means of Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Children of women in the high 25(OH) D tertile (>50.7 nmol/l) had 37% decreased number of hyperactivity–impulsivity symptoms (IRR 0.63, 95% CI 0.39, 0.99,
p
trend
= 0.05) and 40% decreased number of total ADHD-like symptoms (IRR 0.60, 95% CI 0.37, 0.95,
p
trend
= 0.03) at 4 years of age, compared to children of women in the low 25(OH) D tertile (<38.4 nmol/l), after adjustment for several confounders. Similar associations were found with the hyperactivity/inattention score of the SDQ questionnaire. Children of mothers with high 25(OH) D levels had also fewer total behavioral difficulties (beta-coeff: −1.25, 95% CI −2.32, −0.19) and externalizing symptoms (beta-coeff: −0.87, 95% CI −1.58, −0.15) at preschool age. The observed associations were stronger in girls than in boys (
p
for interaction
< 0.1). No association was observed between maternal 25(OH) D concentrations and cognitive function in preschoolers. Our results suggest that high maternal vitamin D levels in early pregnancy may protect against behavioral difficulties, especially ADHD-like symptoms at preschool age.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28685401</pmid><doi>10.1007/s00787-017-1023-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1764-4913</orcidid></addata></record> |
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| ispartof | European child & adolescent psychiatry, 2018-01, Vol.27 (1), p.79-88 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; SpringerLink Journals |
| subjects | 25-Hydroxyvitamin D Adult Age Animals Associations Attention deficit hyperactivity disorder Behavior Brain Brain - physiopathology Child Child & adolescent psychiatry Child and Adolescent Psychiatry Child, Preschool Children Cognitive ability Cognitive functioning Cohort Studies Female Fetuses Greece Humans Hyperactivity Impulsive behavior Impulsivity Male Maternal serum Medicine Medicine & Public Health Mother-child relations Mothers - psychology Original Contribution Pregnancy Prenatal care Preschool children Prospective Studies Protective factors Psychiatry Questionnaires Serum Vitamin D Vitamin D - therapeutic use Women |
| title | High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece |
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