Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3- H19 Cascade

Ubiquitination-directed protein degradation is important in many cancers for tumor initiation and maintenance, and E3 ligases containing HECT domains are emerging as new therapeutic targets. In contrast to many other E3 ligases, the role of HUWE1 in ovarian cancer where HUWE1 is dysregulated has bee...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2017-09, Vol.77 (18), p.4773-4784
Hauptverfasser:	Yang, Dong, Sun, Bin, Zhang, Xiaohong, Cheng, Daomei, Yu, Xiaoping, Yan, Lanzhen, Li, Lei, An, Sanqi, Jiang, Hua, Lasorella, Anna, Iavarone, Antonio, Zhang, Shu, Zou, Fangdong, Zhao, Xudong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Proliferation Cell survival Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Clonal deletion Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium Female Gene Expression Regulation, Neoplastic Genetic transformation Histone H1 Histones - genetics Histones - metabolism Humans Huwe1 protein Mice Mice, Inbred BALB C Mice, Knockout Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Proteasomes Proteolysis Ribonucleic acid RNA RNA-mediated interference Tumor Cells, Cultured Tumors Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Xenograft Model Antitumor Assays
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