Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma

Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpressed in renal cell carcinoma tissues and cells, and...

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Veröffentlicht in:	Experimental cell research 2017-09, Vol.358 (2), p.269-278
Hauptverfasser:	Ruan, HaiLong, Li, Xiang, Yang, HongMei, Song, ZhengShuai, Tong, JunWei, Cao, Qi, Wang, KeShan, Xiao, Wen, Xiao, HaiBin, Chen, XuanYu, Xu, GuangHua, Bao, Lin, Xiong, ZhiYong, Yuan, ChangFei, Liu, Lei, Qu, Yan, Hu, WenJun, Gao, YaoYing, Ru, ZeYuan, Chen, Ke, Zhang, XiaoPing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Carcinoma, Renal Cell - metabolism CAV1 Caveolin 1 - genetics Caveolin 1 - metabolism ccRCC Cell Movement - physiology Cell Proliferation - genetics Cell Proliferation - physiology Diagnosis Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic - genetics Gene Knockdown Techniques - methods Humans Indoles - pharmacology Invasion Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Male Middle Aged Neoplasm Invasiveness Prognosis Pyrroles - pharmacology Sunitinib-resistance Young Adult
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