FOXC1 Regulates FGFR1 Isoform Switching to Promote Invasion Following TGFβ-Induced EMT

Epithelial-to-mesenchymal transition (EMT) is an important physiologic process that drives tissue formation during development, but also contributes to disease pathogenesis, including fibrosis and cancer metastasis. Elevated expression of the transcription factor has been detected in several metasta...

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Veröffentlicht in:	Molecular cancer research 2017-10, Vol.15 (10), p.1341-1353
Hauptverfasser:	Hopkins, Alex, Coatham, Mackenzie L, Berry, Fred B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cell Line, Tumor Cell migration Cell Movement Chromatin Epithelial-Mesenchymal Transition - drug effects Female Fibroblast growth factor 2 Fibroblast growth factor receptor 1 Fibrosis Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene sequencing Humans Immunoprecipitation Invasiveness Mesenchyme Metastases Mice Neoplasm Invasiveness Pathogenesis Receptor, Fibroblast Growth Factor, Type 1 - genetics Ribonucleic acid RNA RNA Isoforms - genetics Sequence Analysis, RNA - methods Switching Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1
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