Indoleamine 2,3-dioxygenase and iron are required for Mycobacterium leprae survival

Our previous study has demonstrated that IL-10 may modulate both indoleamine 2,3-dioxygenase (IDO) and CD163 expression in lepromatous leprosy (LL) cells, favoring Mycobacterium leprae persistence through induction of regulatory pathways and iron storage. Here, we observed that in LL lesion cells th...

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Veröffentlicht in:	Microbes and infection 2017-11, Vol.19 (11), p.505-514
Hauptverfasser:	de Mattos Barbosa, Mayara Garcia, da Silva Prata, Rhana Berto, Andrade, Priscila Ribeiro, Ferreira, Helen, de Andrade Silva, Bruno Jorge, da Paixão de Oliveira, Jéssica Araújo, Assis, Tayná Quintella, de Toledo-Pinto, Thiago Gomes, de Lima Bezerra, Ohanna Cavalcanti, da Costa Nery, José Augusto, Rosa, Patricia Sammarco, Bozza, Marcelo Torres, Lara, Flávio Alves, Moraes, Milton Ozório, Schmitz, Veronica, Sarno, Euzenir Nunes, Pinheiro, Roberta Olmo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female Humans Immunoblotting Immunoenzyme Techniques Indoleamine 2,3-dioxygenase Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology Iron Iron - metabolism Iron - physiology Leprosy Leprosy, Lepromatous - metabolism Leprosy, Lepromatous - microbiology Macrophages Male Middle Aged Mycobacterium leprae Mycobacterium leprae - metabolism Mycobacterium leprae - physiology Reverse Transcriptase Polymerase Chain Reaction
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