Evidence for delayed cytotoxicity effects following exposure of rat hepatoma-derived Fa32 cells: implications for predicting human acute toxicity

The delayed cytotoxicity of the Multicentre Evaluation of In vitro Cytotoxicity (MEIC) reference chemicals was investigated in rat hepatoma-derived Fa32 cells. The cells were treated for 24 h with the test chemicals, and were than further cultured for 5 days in normal culture medium. The cytotoxicit...

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Veröffentlicht in:	Toxicology in vitro 2003-10, Vol.17 (5), p.797-801
1. Verfasser:	Dierickx, Paul J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinoma, Hepatocellular Cell Line, Tumor Cell Survival - drug effects Correlation human toxicity Delayed cytotoxicity Fa32 cells General aspects. Methods Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Humans Inhibitory Concentration 50 Liver Neoplasms Medical sciences MEIC Neutral Red - metabolism Neutral red uptake Predictive Value of Tests Rats Reproducibility of Results Time Factors Toxicity Tests, Acute - methods Toxicology Xenobiotics - toxicity
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