Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2

Accumulating data indicate that renal uric acid (UA) handling is altered in diabetes and by hypoglycemic agents. In addition, hyperinsulinemia is associated with hyperuricemia and hypouricosuria. However, the underlying mechanisms remain unclear. In this study, we aimed to investigate how diabetes a...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2017-09, Vol.313 (3), p.F826-F834
Hauptverfasser:	Toyoki, Daigo, Shibata, Shigeru, Kuribayashi-Okuma, Emiko, Xu, Ning, Ishizawa, Kenichi, Hosoyamada, Makoto, Uchida, Shunya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animals Anion Transport Proteins - metabolism ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism Binding sites Blood glucose Blood Glucose - drug effects Blood Glucose - metabolism Cell Line Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Epithelial cells Excretion Glucosides - pharmacology Hyperinsulinemia Hyperuricemia Hypoglycemic agents Hypoglycemic Agents - pharmacology Insulin Insulin - pharmacology Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - physiopathology Kidneys Male Na+/glucose cotransporter Proteins Rats, Sprague-Dawley Reabsorption Renal Elimination - drug effects Renal function Renal Reabsorption - drug effects Sodium Sodium-Glucose Transporter 2 - antagonists & inhibitors Sodium-Glucose Transporter 2 - metabolism Streptozocin Thiophenes - pharmacology Time Factors Uric acid Uric Acid - metabolism Uric Acid - urine
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