Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral env RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth

We investigated the role of the human endogenous retrovirus type K (HERV-K) envelope ( ) gene in pancreatic cancer. shRNA was employed to knockdown (KD) the expression of HERV-K in pancreatic cancer cells. HERV-K expression was detected in seven pancreatic cancer cell lines and in 80% of pancreatic...

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Veröffentlicht in:	Clinical cancer research 2017-10, Vol.23 (19), p.5892-5911
Hauptverfasser:	Li, Ming, Radvanyi, Laszlo, Yin, Bingnan, Rycaj, Kiera, Li, Jia, Chivukula, Raghavender, Lin, Kevin, Lu, Yue, Shen, JianJun, Chang, David Z, Li, Donghui, Johanning, Gary L, Wang-Johanning, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Alternative splicing Antigen (tumor-associated) Antigens Biomarkers Biotechnology Cancer Carcinogenesis - genetics Cell culture Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Culture media Endogenous Retroviruses - genetics Endogenous Retroviruses - pathogenicity Env gene Experimental design Gene expression Gene Expression Regulation, Neoplastic Gene Expression Regulation, Viral Gene Knockdown Techniques Growth rate Host-Pathogen Interactions - genetics Humans Immunotherapy Lungs Metastases p53 Protein Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatic Neoplasms - virology Proteins Recombinant Fusion Proteins - genetics Ribonucleic acid RNA RNA, Small Interfering - genetics RNA-directed DNA polymerase Signal transduction Signal Transduction - genetics Target detection Tissues Transduction Tumor cell lines Tumorigenesis Tumors Viral envelope proteins Viral Envelope Proteins - genetics Virus-like particles Viruses
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