Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor

Head and neck squamous cell carcinomas (HNSCC) are characterized by upregulation of the epidermal growth factor receptor (EGFR), where EGFR serves as a potential therapeutic target. We previously reported that a gastrin-releasing peptide/gastrin-releasing peptide receptor (GRP/GRPR) autocrine growth...

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Veröffentlicht in:	Oncogene 2003-09, Vol.22 (40), p.6183-6193
Hauptverfasser:	Lui, Vivian Wai Yan, Thomas, Sufi Mary, Zhang, Qing, Wentzel, Abbey Lynn, Siegfried, Jill Marie, Li, Joyce Yan, Grandis, Jennifer Rubin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autocrine signalling Biological and medical sciences Cancer Carcinogenesis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell activation Cell Biology Cell Division - drug effects Cell physiology Cell proliferation Cell receptors Cell structures and functions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Enzyme Activation Enzyme Inhibitors - pharmacology Epidermal growth factor Epidermal growth factor receptors Fibroblasts Fundamental and applied biological sciences. Psychology Gastrin Gastrin-releasing peptide Gastrin-Releasing Peptide - pharmacology Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Human Genetics Humans Internal Medicine Kinases Ligands MAP kinase MAP Kinase Kinase Kinase 1 Matrix metalloproteinase Medical sciences Medicine Medicine & Public Health Mice Mice, Knockout Miscellaneous Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Mitogens - pharmacology Molecular and cellular biology Oncology original-paper Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Peptides Phosphorylation Prostate Protein-Serine-Threonine Kinases - metabolism Protein-tyrosine kinase Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Receptor, Epidermal Growth Factor - physiology Receptors, Bombesin - metabolism Signal Transduction Squamous cell carcinoma Therapeutic targets Transcriptional Activation Transforming growth factor-a Tumor Cells, Cultured Tumors
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