Primary cortical neuronal cultures reduce cellular energy utilization during anoxic energy deprivation

It has been widely hypothesized that neurons reduce cellular energy use in response to periods of energy deprivation. To test this hypothesis, we measured rates of energy use under normoxia and anoxia in immature (6 days in vitro) and mature (13 days in vitro) neuronal cultures. During anoxic incuba...

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Veröffentlicht in:	Journal of neurochemistry 2003-11, Vol.87 (3), p.764-772
Hauptverfasser:	Munns, Shane E., Meloni, Bruno P., Knuckey, Neville W., Arthur, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals anoxia Biochemistry and metabolism Biological and medical sciences Cell Hypoxia - physiology Cells, Cultured cellular energy use Central nervous system Cerebral Cortex - cytology Energy Metabolism - physiology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Glucose - metabolism glutamate receptors Glutamic Acid - toxicity Glycogen - metabolism ischemia metabolic depression neuron Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotoxins - toxicity Oxygen - metabolism Rats Rats, Sprague-Dawley Receptors, Glutamate - drug effects Receptors, Glutamate - metabolism Time Factors Vertebrates: nervous system and sense organs
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