Plant bioactive molecules bearing glycosides as lead compounds for the treatment of fungal infection: A review
Despite therapeutic advancement in the treatment of fungal infections, morbidity and mortality caused by these infections are still very high. There are approximately 300 fungal species that are infectious and can cause a variety of diseases. At present, several synthetic antifungal drugs are in cli...
Gespeichert in:
| Veröffentlicht in: | Biomedicine & pharmacotherapy 2017-09, Vol.93, p.498-509 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 509 |
|---|---|
| container_issue | |
| container_start_page | 498 |
| container_title | Biomedicine & pharmacotherapy |
| container_volume | 93 |
| creator | Khan, Haroon Khan, Ziyad Amin, Surriya Mabkhot, Yahia Nasser Mubarak, Mohammad S. Hadda, Taibi Ben Maione, Francesco |
| description | Despite therapeutic advancement in the treatment of fungal infections, morbidity and mortality caused by these infections are still very high. There are approximately 300 fungal species that are infectious and can cause a variety of diseases. At present, several synthetic antifungal drugs are in clinical practice, many of them, however, are vulnerable to multidrug-resistant strains of microbes, and thus compromising the overall treatment outcomes. Glycosides are naturally occurring plant secondary metabolites with important therapeutic potential and clinical utility. The aim of this review was to focus on the antifungal effects of glycosides in preclinical studies with possible mechanism(s) wherein described. Published research show significant susceptibility of different fungi towards phytoglycosides, mediated through multiple mechanisms. Further detailed studies are needed to explain the clinical applications and limitations of these glycosides. |
| doi_str_mv | 10.1016/j.biopha.2017.06.077 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1916385549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0753332217321492</els_id><sourcerecordid>1916385549</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-e499395072716fd456025d33c524d4fe6e1917c9e4484d6c1130792f000bebbf3</originalsourceid><addsrcrecordid>eNp9kM9LHDEYhkOx1HXb_6CUHL3MNL-z40GQpVVBaA_tOWSSL2uWmcmazFj87xtZ9egpEN73_XgehL5S0lJC1fd928d0uLctI1S3RLVE6w9oRTtJGkWIPkEroiVvOGfsFJ2VsieESMU3n9Ap2ygtN1Kt0PR7sNOM65R1c3wEPKYB3DJAwT3YHKcd3g1PLpXo65cteADrsUvjIS2TLzikjOd7wHMGO49Qp1LAYZl2dsBxClBH03SBr3CGxwj_PqOPwQ4Fvry8a_T3548_25vm7tf17fbqrnFcsbkB0XW8gmimqQpeSEWY9Jw7yYQXARTQjmrXgRAb4ZWjlBPdsVAJe-j7wNfo_Lh7yOlhgTKbMRYHQ4WFtBRT69WElKKrUXGMupxKyRDMIcfR5idDiXk2bfbmaNo8mzZEmWq61r69XFj6Efxb6VVtDVweA1A5K3s2xUWYHPiYqxbjU3z_wn_ASJGr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1916385549</pqid></control><display><type>article</type><title>Plant bioactive molecules bearing glycosides as lead compounds for the treatment of fungal infection: A review</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Khan, Haroon ; Khan, Ziyad ; Amin, Surriya ; Mabkhot, Yahia Nasser ; Mubarak, Mohammad S. ; Hadda, Taibi Ben ; Maione, Francesco</creator><creatorcontrib>Khan, Haroon ; Khan, Ziyad ; Amin, Surriya ; Mabkhot, Yahia Nasser ; Mubarak, Mohammad S. ; Hadda, Taibi Ben ; Maione, Francesco</creatorcontrib><description>Despite therapeutic advancement in the treatment of fungal infections, morbidity and mortality caused by these infections are still very high. There are approximately 300 fungal species that are infectious and can cause a variety of diseases. At present, several synthetic antifungal drugs are in clinical practice, many of them, however, are vulnerable to multidrug-resistant strains of microbes, and thus compromising the overall treatment outcomes. Glycosides are naturally occurring plant secondary metabolites with important therapeutic potential and clinical utility. The aim of this review was to focus on the antifungal effects of glycosides in preclinical studies with possible mechanism(s) wherein described. Published research show significant susceptibility of different fungi towards phytoglycosides, mediated through multiple mechanisms. Further detailed studies are needed to explain the clinical applications and limitations of these glycosides.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2017.06.077</identifier><identifier>PMID: 28675856</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Alternative antifungal therapy ; Animals ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Drug Resistance, Fungal - drug effects ; Fungal infections ; Glycosides - chemistry ; Glycosides - pharmacology ; Glycosides - therapeutic use ; Humans ; Mycoses - drug therapy ; Natural glycosides</subject><ispartof>Biomedicine & pharmacotherapy, 2017-09, Vol.93, p.498-509</ispartof><rights>2017 Elsevier Masson SAS</rights><rights>Copyright © 2017 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-e499395072716fd456025d33c524d4fe6e1917c9e4484d6c1130792f000bebbf3</citedby><cites>FETCH-LOGICAL-c362t-e499395072716fd456025d33c524d4fe6e1917c9e4484d6c1130792f000bebbf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0753332217321492$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28675856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Haroon</creatorcontrib><creatorcontrib>Khan, Ziyad</creatorcontrib><creatorcontrib>Amin, Surriya</creatorcontrib><creatorcontrib>Mabkhot, Yahia Nasser</creatorcontrib><creatorcontrib>Mubarak, Mohammad S.</creatorcontrib><creatorcontrib>Hadda, Taibi Ben</creatorcontrib><creatorcontrib>Maione, Francesco</creatorcontrib><title>Plant bioactive molecules bearing glycosides as lead compounds for the treatment of fungal infection: A review</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Despite therapeutic advancement in the treatment of fungal infections, morbidity and mortality caused by these infections are still very high. There are approximately 300 fungal species that are infectious and can cause a variety of diseases. At present, several synthetic antifungal drugs are in clinical practice, many of them, however, are vulnerable to multidrug-resistant strains of microbes, and thus compromising the overall treatment outcomes. Glycosides are naturally occurring plant secondary metabolites with important therapeutic potential and clinical utility. The aim of this review was to focus on the antifungal effects of glycosides in preclinical studies with possible mechanism(s) wherein described. Published research show significant susceptibility of different fungi towards phytoglycosides, mediated through multiple mechanisms. Further detailed studies are needed to explain the clinical applications and limitations of these glycosides.</description><subject>Alternative antifungal therapy</subject><subject>Animals</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Drug Resistance, Fungal - drug effects</subject><subject>Fungal infections</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - pharmacology</subject><subject>Glycosides - therapeutic use</subject><subject>Humans</subject><subject>Mycoses - drug therapy</subject><subject>Natural glycosides</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LHDEYhkOx1HXb_6CUHL3MNL-z40GQpVVBaA_tOWSSL2uWmcmazFj87xtZ9egpEN73_XgehL5S0lJC1fd928d0uLctI1S3RLVE6w9oRTtJGkWIPkEroiVvOGfsFJ2VsieESMU3n9Ap2ygtN1Kt0PR7sNOM65R1c3wEPKYB3DJAwT3YHKcd3g1PLpXo65cteADrsUvjIS2TLzikjOd7wHMGO49Qp1LAYZl2dsBxClBH03SBr3CGxwj_PqOPwQ4Fvry8a_T3548_25vm7tf17fbqrnFcsbkB0XW8gmimqQpeSEWY9Jw7yYQXARTQjmrXgRAb4ZWjlBPdsVAJe-j7wNfo_Lh7yOlhgTKbMRYHQ4WFtBRT69WElKKrUXGMupxKyRDMIcfR5idDiXk2bfbmaNo8mzZEmWq61r69XFj6Efxb6VVtDVweA1A5K3s2xUWYHPiYqxbjU3z_wn_ASJGr</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Khan, Haroon</creator><creator>Khan, Ziyad</creator><creator>Amin, Surriya</creator><creator>Mabkhot, Yahia Nasser</creator><creator>Mubarak, Mohammad S.</creator><creator>Hadda, Taibi Ben</creator><creator>Maione, Francesco</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Plant bioactive molecules bearing glycosides as lead compounds for the treatment of fungal infection: A review</title><author>Khan, Haroon ; Khan, Ziyad ; Amin, Surriya ; Mabkhot, Yahia Nasser ; Mubarak, Mohammad S. ; Hadda, Taibi Ben ; Maione, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-e499395072716fd456025d33c524d4fe6e1917c9e4484d6c1130792f000bebbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alternative antifungal therapy</topic><topic>Animals</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>Drug Resistance, Fungal - drug effects</topic><topic>Fungal infections</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - pharmacology</topic><topic>Glycosides - therapeutic use</topic><topic>Humans</topic><topic>Mycoses - drug therapy</topic><topic>Natural glycosides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Haroon</creatorcontrib><creatorcontrib>Khan, Ziyad</creatorcontrib><creatorcontrib>Amin, Surriya</creatorcontrib><creatorcontrib>Mabkhot, Yahia Nasser</creatorcontrib><creatorcontrib>Mubarak, Mohammad S.</creatorcontrib><creatorcontrib>Hadda, Taibi Ben</creatorcontrib><creatorcontrib>Maione, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Haroon</au><au>Khan, Ziyad</au><au>Amin, Surriya</au><au>Mabkhot, Yahia Nasser</au><au>Mubarak, Mohammad S.</au><au>Hadda, Taibi Ben</au><au>Maione, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant bioactive molecules bearing glycosides as lead compounds for the treatment of fungal infection: A review</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2017-09</date><risdate>2017</risdate><volume>93</volume><spage>498</spage><epage>509</epage><pages>498-509</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Despite therapeutic advancement in the treatment of fungal infections, morbidity and mortality caused by these infections are still very high. There are approximately 300 fungal species that are infectious and can cause a variety of diseases. At present, several synthetic antifungal drugs are in clinical practice, many of them, however, are vulnerable to multidrug-resistant strains of microbes, and thus compromising the overall treatment outcomes. Glycosides are naturally occurring plant secondary metabolites with important therapeutic potential and clinical utility. The aim of this review was to focus on the antifungal effects of glycosides in preclinical studies with possible mechanism(s) wherein described. Published research show significant susceptibility of different fungi towards phytoglycosides, mediated through multiple mechanisms. Further detailed studies are needed to explain the clinical applications and limitations of these glycosides.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>28675856</pmid><doi>10.1016/j.biopha.2017.06.077</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0753-3322 |
| ispartof | Biomedicine & pharmacotherapy, 2017-09, Vol.93, p.498-509 |
| issn | 0753-3322 1950-6007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1916385549 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alternative antifungal therapy Animals Antifungal Agents - chemistry Antifungal Agents - pharmacology Drug Resistance, Fungal - drug effects Fungal infections Glycosides - chemistry Glycosides - pharmacology Glycosides - therapeutic use Humans Mycoses - drug therapy Natural glycosides |
| title | Plant bioactive molecules bearing glycosides as lead compounds for the treatment of fungal infection: A review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T00%3A32%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plant%20bioactive%20molecules%20bearing%20glycosides%20as%20lead%20compounds%20for%20the%20treatment%20of%20fungal%20infection:%20A%20review&rft.jtitle=Biomedicine%20&%20pharmacotherapy&rft.au=Khan,%20Haroon&rft.date=2017-09&rft.volume=93&rft.spage=498&rft.epage=509&rft.pages=498-509&rft.issn=0753-3322&rft.eissn=1950-6007&rft_id=info:doi/10.1016/j.biopha.2017.06.077&rft_dat=%3Cproquest_cross%3E1916385549%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1916385549&rft_id=info:pmid/28675856&rft_els_id=S0753332217321492&rfr_iscdi=true |