Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis

Objective Increased Wnt signaling in chondrocytes is associated with development of osteoarthritis (OA). However, OA is considered a disease of the entire joint, where the synovium has been attributed an important role in disease pathogenesis and progression. This study was undertaken to determine w...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2017-10, Vol.69 (10), p.1978-1983
Hauptverfasser:	van den Bosch, Martijn H., Blom, Arjen B., van de Loo, Fons A., Koenders, Marije I., Lafeber, Floris P., van den Berg, Wim B., van der Kraan, Peter M., van Lent, Peter L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Arthritis Arthroscopy Biocompatibility Biomedical materials Chondrocytes Correlation analysis Disease Progression Dkk1 protein Expression vectors Female Frizzled protein Frizzled Receptors - genetics Gene expression Gene Knock-In Techniques Glycoproteins - genetics Heparan sulfate Hip Humans Inhibition Knee Male Matrix metalloproteinase Matrix metalloproteinases Matrix Metalloproteinases - genetics Metalloproteinase Mice Middle Aged Netherlands Osteoarthritis Osteoarthritis, Knee - genetics Osteoarthritis, Knee - metabolism Pain Pathogenesis Patients Polymerase chain reaction Real-Time Polymerase Chain Reaction Receptors Reverse Transcriptase Polymerase Chain Reaction Reverse transcription Ribonucleic acid RNA RNA, Messenger - metabolism Stimulation Synovial Membrane - metabolism Synovium Wnt protein Wnt Proteins - genetics Wnt Signaling Pathway - genetics
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