Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications

Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications

Atomic layer deposition on pharmaceutical particles for drug delivery applications is demonstrated using assisted fluidized bed dry powder processing. Complete and conformal layering is achieved on particle sizes from the lower micron to upper nanometer range under near ambient conditions. As few as...

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Veröffentlicht in:Nanoscale 2017-08, Vol.9 (32), p.11410-11417
Hauptverfasser: Zhang, D, Quayle, M J, Petersson, G, van Ommen, J R, Folestad, S
Format: Artikel
Sprache:eng
Schlagworte:
Aluminum Oxide - chemistry
Budesonide - chemistry
Drug Carriers - chemical synthesis
Drug Delivery Systems
Lactose - chemistry
Particle Size
Powders - chemical synthesis
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container_end_page 11417
container_issue 32
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container_title Nanoscale
container_volume 9
creator Zhang, D
Quayle, M J
Petersson, G
van Ommen, J R
Folestad, S
description Atomic layer deposition on pharmaceutical particles for drug delivery applications is demonstrated using assisted fluidized bed dry powder processing. Complete and conformal layering is achieved on particle sizes from the lower micron to upper nanometer range under near ambient conditions. As few as 2-14 atomic alumina layers alter particle properties: dissolution, dispersibility and heat transfer.
doi_str_mv 10.1039/c7nr03261g
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source MEDLINE; Royal Society Of Chemistry Journals 2008-
subjects Aluminum Oxide - chemistry
Budesonide - chemistry
Drug Carriers - chemical synthesis
Drug Delivery Systems
Lactose - chemistry
Particle Size
Powders - chemical synthesis
title Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications
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