Role of adipocytokines in the pathophysiology of migraine: A cross-sectional study
Background Obesity is a risk factor for migraine and headache chronification. Adipocytokines may be involved in this correlation. Objective To relate serum adipocytokine levels to clinical and biochemical parameters associated with migraine. Methods We measured levels of leptin, adiponectin and othe...
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| Veröffentlicht in: | Cephalalgia 2018-04, Vol.38 (5), p.904-911 |
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| creator | Domínguez, Clara Vieites-Prado, Alba Pérez-Mato, María Sobrino, Tomás Rodríguez-Osorio, Xiana López, Ana Campos, Francisco Martínez, Francisco Castillo, José Leira, Rogelio |
| description | Background
Obesity is a risk factor for migraine and headache chronification. Adipocytokines may be involved in this correlation.
Objective
To relate serum adipocytokine levels to clinical and biochemical parameters associated with migraine.
Methods
We measured levels of leptin, adiponectin and other inflammatory (interleukin 6, interleukin 10, tumor necrosis factor α, high sensitivity C-reactive protein) and endothelial (pentraxin 3, soluble TNF-like weak inducer of apoptosis) molecules potentially related to migraine pathophysiology in a group of migraine patients (IHS 2013) and healthy controls.
Results
One hundred and eleven patients (mean age 39.7 years, 93% female) and 24 healthy controls (mean age 35.9 years, 90% female) were included. Fifty-six patients were diagnosed with episodic migraine (mean age 35.1 years, 98.2% female) and 55 patients with chronic migraine (mean age 44.4 years, 89.5% female). Leptin serum levels (15.2 ng/mL, SD = 10.5 vs. 3.1 ng/mL, SD = 0.9; p |
| doi_str_mv | 10.1177/0333102417720213 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_miscellaneous_1916380421</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0333102417720213</sage_id><sourcerecordid>1916380421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-6772631820f06ee49fd6cb1a612586d39b75cb4a5caccd0672bab10ed353e3373</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqWwMyGPLIGznTgJW1XxJVVCqmCOHOfSuiRxiJMh_x6HAgMS0510z_vq9BByyeCGsTi-BSEEAx76nQNn4ojMWSiTgKcJPybz6RxM9xk5c24PAJEEeUpmPJFxnKbRnGw2tkJqS6oK01o99vbdNOioaWi_Q9qqfmfb3eiMrex2nMDabDvlmTu6pLqzzgUOdW9soyrq-qEYz8lJqSqHF99zQd4e7l9XT8H65fF5tVwHWoi4D_wHXAqWcChBIoZpWUidMyUZjxJZiDSPI52HKtJK6wJkzHOVM8BCRAJ9g1iQ60Nv29mPAV2f1cZprCrVoB1cxlImRQKh97IgcEC_Hu6wzNrO1KobMwbZZDL7a9JHrr7bh7zG4jfwo84DwQFwaovZ3g6dN-D-L_wEPNt6xg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1916380421</pqid></control><display><type>article</type><title>Role of adipocytokines in the pathophysiology of migraine: A cross-sectional study</title><source>Sage Journals GOLD Open Access 2024</source><creator>Domínguez, Clara ; Vieites-Prado, Alba ; Pérez-Mato, María ; Sobrino, Tomás ; Rodríguez-Osorio, Xiana ; López, Ana ; Campos, Francisco ; Martínez, Francisco ; Castillo, José ; Leira, Rogelio</creator><creatorcontrib>Domínguez, Clara ; Vieites-Prado, Alba ; Pérez-Mato, María ; Sobrino, Tomás ; Rodríguez-Osorio, Xiana ; López, Ana ; Campos, Francisco ; Martínez, Francisco ; Castillo, José ; Leira, Rogelio</creatorcontrib><description><![CDATA[Background
Obesity is a risk factor for migraine and headache chronification. Adipocytokines may be involved in this correlation.
Objective
To relate serum adipocytokine levels to clinical and biochemical parameters associated with migraine.
Methods
We measured levels of leptin, adiponectin and other inflammatory (interleukin 6, interleukin 10, tumor necrosis factor α, high sensitivity C-reactive protein) and endothelial (pentraxin 3, soluble TNF-like weak inducer of apoptosis) molecules potentially related to migraine pathophysiology in a group of migraine patients (IHS 2013) and healthy controls.
Results
One hundred and eleven patients (mean age 39.7 years, 93% female) and 24 healthy controls (mean age 35.9 years, 90% female) were included. Fifty-six patients were diagnosed with episodic migraine (mean age 35.1 years, 98.2% female) and 55 patients with chronic migraine (mean age 44.4 years, 89.5% female). Leptin serum levels (15.2 ng/mL, SD = 10.5 vs. 3.1 ng/mL, SD = 0.9; p < 0.001) and adiponectin serum levels (72.3 µg/mL, SD = 38.5 vs. 37.7 µg/mL, SD = 16.9; p < 0.001) were significantly increased in migraine patients. Leptin serum levels (15.5 ng/mL, SD = 9.7 vs. 10.8 ng/mL, SD = 6.0; p < 0.001) and adiponectin serum levels (65.8 µg/mL, SD = 42.9 vs. 33.2 µg/mL, SD = 31.0; p < 0.001) were significantly higher in chronic compared to episodic migraine patients. We found a positive correlation between leptin levels and inflammatory biomarkers: IL6 (r = 0.498; p < 0.001), TNF-α (r = 0.389; p < 0.001), and hs-CRP (r = 0.422; p < 0.001).
Conclusions
Leptin and adiponectin are increased in migraineurs. There is a correlation between adipocytokine levels and other inflammation-related molecules. This suggests a potential role of adipocytokines in migraine pathophysiology and chronification.]]></description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1177/0333102417720213</identifier><identifier>PMID: 28677995</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adipokines - blood ; Adult ; Biomarkers - blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Migraine Disorders - blood ; Migraine Disorders - diagnosis ; Migraine Disorders - physiopathology</subject><ispartof>Cephalalgia, 2018-04, Vol.38 (5), p.904-911</ispartof><rights>International Headache Society 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-6772631820f06ee49fd6cb1a612586d39b75cb4a5caccd0672bab10ed353e3373</citedby><cites>FETCH-LOGICAL-c337t-6772631820f06ee49fd6cb1a612586d39b75cb4a5caccd0672bab10ed353e3373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0333102417720213$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0333102417720213$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0333102417720213?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28677995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domínguez, Clara</creatorcontrib><creatorcontrib>Vieites-Prado, Alba</creatorcontrib><creatorcontrib>Pérez-Mato, María</creatorcontrib><creatorcontrib>Sobrino, Tomás</creatorcontrib><creatorcontrib>Rodríguez-Osorio, Xiana</creatorcontrib><creatorcontrib>López, Ana</creatorcontrib><creatorcontrib>Campos, Francisco</creatorcontrib><creatorcontrib>Martínez, Francisco</creatorcontrib><creatorcontrib>Castillo, José</creatorcontrib><creatorcontrib>Leira, Rogelio</creatorcontrib><title>Role of adipocytokines in the pathophysiology of migraine: A cross-sectional study</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description><![CDATA[Background
Obesity is a risk factor for migraine and headache chronification. Adipocytokines may be involved in this correlation.
Objective
To relate serum adipocytokine levels to clinical and biochemical parameters associated with migraine.
Methods
We measured levels of leptin, adiponectin and other inflammatory (interleukin 6, interleukin 10, tumor necrosis factor α, high sensitivity C-reactive protein) and endothelial (pentraxin 3, soluble TNF-like weak inducer of apoptosis) molecules potentially related to migraine pathophysiology in a group of migraine patients (IHS 2013) and healthy controls.
Results
One hundred and eleven patients (mean age 39.7 years, 93% female) and 24 healthy controls (mean age 35.9 years, 90% female) were included. Fifty-six patients were diagnosed with episodic migraine (mean age 35.1 years, 98.2% female) and 55 patients with chronic migraine (mean age 44.4 years, 89.5% female). Leptin serum levels (15.2 ng/mL, SD = 10.5 vs. 3.1 ng/mL, SD = 0.9; p < 0.001) and adiponectin serum levels (72.3 µg/mL, SD = 38.5 vs. 37.7 µg/mL, SD = 16.9; p < 0.001) were significantly increased in migraine patients. Leptin serum levels (15.5 ng/mL, SD = 9.7 vs. 10.8 ng/mL, SD = 6.0; p < 0.001) and adiponectin serum levels (65.8 µg/mL, SD = 42.9 vs. 33.2 µg/mL, SD = 31.0; p < 0.001) were significantly higher in chronic compared to episodic migraine patients. We found a positive correlation between leptin levels and inflammatory biomarkers: IL6 (r = 0.498; p < 0.001), TNF-α (r = 0.389; p < 0.001), and hs-CRP (r = 0.422; p < 0.001).
Conclusions
Leptin and adiponectin are increased in migraineurs. There is a correlation between adipocytokine levels and other inflammation-related molecules. This suggests a potential role of adipocytokines in migraine pathophysiology and chronification.]]></description><subject>Adipokines - blood</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Migraine Disorders - blood</subject><subject>Migraine Disorders - diagnosis</subject><subject>Migraine Disorders - physiopathology</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqWwMyGPLIGznTgJW1XxJVVCqmCOHOfSuiRxiJMh_x6HAgMS0510z_vq9BByyeCGsTi-BSEEAx76nQNn4ojMWSiTgKcJPybz6RxM9xk5c24PAJEEeUpmPJFxnKbRnGw2tkJqS6oK01o99vbdNOioaWi_Q9qqfmfb3eiMrex2nMDabDvlmTu6pLqzzgUOdW9soyrq-qEYz8lJqSqHF99zQd4e7l9XT8H65fF5tVwHWoi4D_wHXAqWcChBIoZpWUidMyUZjxJZiDSPI52HKtJK6wJkzHOVM8BCRAJ9g1iQ60Nv29mPAV2f1cZprCrVoB1cxlImRQKh97IgcEC_Hu6wzNrO1KobMwbZZDL7a9JHrr7bh7zG4jfwo84DwQFwaovZ3g6dN-D-L_wEPNt6xg</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Domínguez, Clara</creator><creator>Vieites-Prado, Alba</creator><creator>Pérez-Mato, María</creator><creator>Sobrino, Tomás</creator><creator>Rodríguez-Osorio, Xiana</creator><creator>López, Ana</creator><creator>Campos, Francisco</creator><creator>Martínez, Francisco</creator><creator>Castillo, José</creator><creator>Leira, Rogelio</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>Role of adipocytokines in the pathophysiology of migraine: A cross-sectional study</title><author>Domínguez, Clara ; Vieites-Prado, Alba ; Pérez-Mato, María ; Sobrino, Tomás ; Rodríguez-Osorio, Xiana ; López, Ana ; Campos, Francisco ; Martínez, Francisco ; Castillo, José ; Leira, Rogelio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-6772631820f06ee49fd6cb1a612586d39b75cb4a5caccd0672bab10ed353e3373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipokines - blood</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Migraine Disorders - blood</topic><topic>Migraine Disorders - diagnosis</topic><topic>Migraine Disorders - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domínguez, Clara</creatorcontrib><creatorcontrib>Vieites-Prado, Alba</creatorcontrib><creatorcontrib>Pérez-Mato, María</creatorcontrib><creatorcontrib>Sobrino, Tomás</creatorcontrib><creatorcontrib>Rodríguez-Osorio, Xiana</creatorcontrib><creatorcontrib>López, Ana</creatorcontrib><creatorcontrib>Campos, Francisco</creatorcontrib><creatorcontrib>Martínez, Francisco</creatorcontrib><creatorcontrib>Castillo, José</creatorcontrib><creatorcontrib>Leira, Rogelio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Domínguez, Clara</au><au>Vieites-Prado, Alba</au><au>Pérez-Mato, María</au><au>Sobrino, Tomás</au><au>Rodríguez-Osorio, Xiana</au><au>López, Ana</au><au>Campos, Francisco</au><au>Martínez, Francisco</au><au>Castillo, José</au><au>Leira, Rogelio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of adipocytokines in the pathophysiology of migraine: A cross-sectional study</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2018-04</date><risdate>2018</risdate><volume>38</volume><issue>5</issue><spage>904</spage><epage>911</epage><pages>904-911</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract><![CDATA[Background
Obesity is a risk factor for migraine and headache chronification. Adipocytokines may be involved in this correlation.
Objective
To relate serum adipocytokine levels to clinical and biochemical parameters associated with migraine.
Methods
We measured levels of leptin, adiponectin and other inflammatory (interleukin 6, interleukin 10, tumor necrosis factor α, high sensitivity C-reactive protein) and endothelial (pentraxin 3, soluble TNF-like weak inducer of apoptosis) molecules potentially related to migraine pathophysiology in a group of migraine patients (IHS 2013) and healthy controls.
Results
One hundred and eleven patients (mean age 39.7 years, 93% female) and 24 healthy controls (mean age 35.9 years, 90% female) were included. Fifty-six patients were diagnosed with episodic migraine (mean age 35.1 years, 98.2% female) and 55 patients with chronic migraine (mean age 44.4 years, 89.5% female). Leptin serum levels (15.2 ng/mL, SD = 10.5 vs. 3.1 ng/mL, SD = 0.9; p < 0.001) and adiponectin serum levels (72.3 µg/mL, SD = 38.5 vs. 37.7 µg/mL, SD = 16.9; p < 0.001) were significantly increased in migraine patients. Leptin serum levels (15.5 ng/mL, SD = 9.7 vs. 10.8 ng/mL, SD = 6.0; p < 0.001) and adiponectin serum levels (65.8 µg/mL, SD = 42.9 vs. 33.2 µg/mL, SD = 31.0; p < 0.001) were significantly higher in chronic compared to episodic migraine patients. We found a positive correlation between leptin levels and inflammatory biomarkers: IL6 (r = 0.498; p < 0.001), TNF-α (r = 0.389; p < 0.001), and hs-CRP (r = 0.422; p < 0.001).
Conclusions
Leptin and adiponectin are increased in migraineurs. There is a correlation between adipocytokine levels and other inflammation-related molecules. This suggests a potential role of adipocytokines in migraine pathophysiology and chronification.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>28677995</pmid><doi>10.1177/0333102417720213</doi><tpages>8</tpages></addata></record> |
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| issn | 0333-1024 1468-2982 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adipokines - blood Adult Biomarkers - blood Cross-Sectional Studies Female Humans Male Middle Aged Migraine Disorders - blood Migraine Disorders - diagnosis Migraine Disorders - physiopathology |
| title | Role of adipocytokines in the pathophysiology of migraine: A cross-sectional study |
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