MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of malignant pancreatic tumor. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in tumorigenesis and progression of PDAC. In the present study, we demonstrated that miR-448 expression...
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| Veröffentlicht in: | Oncology reports 2017-08, Vol.38 (2), p.1075-1082 |
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| creator | Yu, Dan-Li Zhang, Tao Wu, Kun Li, Yan Wang, Juan Chen, Jun Li, Xiao-Quan Peng, Xing-Guo Wang, Jia-Ning Tan, Li-Guo |
| description | Pancreatic ductal adenocarcinoma (PDAC) is the most common type of malignant pancreatic tumor. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in tumorigenesis and progression of PDAC. In the present study, we demonstrated that miR-448 expression was downregulated in PDAC tissues and cell lines. Clinical association analysis indicated that low expression of miR-448 was associated with poor prognostic features and conferred a significant reduced survival of PDAC patients. Overexpression of miR-448 suppressed PDAC cell migration and invasion, while its loss showed the opposite effects on these cellular processes. In vivo experiments revealed that miR-488 restoration prohibited liver metastasis of PDAC in nude mice. Moreover, we found that Janus kinase 1 (JAK1) was a direct target gene of miR-448 in PDAC cells. We further demonstrated that the expression of JAK1 mRNA was upregulated in PDAC tissues. Notably, the expression of JAK1 mRNA was inversely correlated with the level of miR-448 in PDAC tissues. In addition, JAK1 knockdown showed similar effects of miR-448 on the metastasis of PDAC cells. JAK1/STAT3 pathway may be involved in the function of miR-448 in PDAC cells. Taken together, these findings suggest that miR-448 functions as a tumor suppressor in the development of PDAC through targeting the JAK1/STAT3 pathway. |
| doi_str_mv | 10.3892/or.2017.5781 |
| format | Article |
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MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in tumorigenesis and progression of PDAC. In the present study, we demonstrated that miR-448 expression was downregulated in PDAC tissues and cell lines. Clinical association analysis indicated that low expression of miR-448 was associated with poor prognostic features and conferred a significant reduced survival of PDAC patients. Overexpression of miR-448 suppressed PDAC cell migration and invasion, while its loss showed the opposite effects on these cellular processes. In vivo experiments revealed that miR-488 restoration prohibited liver metastasis of PDAC in nude mice. Moreover, we found that Janus kinase 1 (JAK1) was a direct target gene of miR-448 in PDAC cells. We further demonstrated that the expression of JAK1 mRNA was upregulated in PDAC tissues. Notably, the expression of JAK1 mRNA was inversely correlated with the level of miR-448 in PDAC tissues. In addition, JAK1 knockdown showed similar effects of miR-448 on the metastasis of PDAC cells. JAK1/STAT3 pathway may be involved in the function of miR-448 in PDAC cells. Taken together, these findings suggest that miR-448 functions as a tumor suppressor in the development of PDAC through targeting the JAK1/STAT3 pathway.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.2017.5781</identifier><identifier>PMID: 28677798</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject><![CDATA[Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - prevention & control ; Adenocarcinoma - secondary ; Animals ; Apoptosis ; Biomarkers, Tumor ; Cancer metastasis ; Carcinoma, Pancreatic Ductal - genetics ; Carcinoma, Pancreatic Ductal - metabolism ; Carcinoma, Pancreatic Ductal - prevention & control ; Carcinoma, Pancreatic Ductal - secondary ; Care and treatment ; Case-Control Studies ; Cell adhesion & migration ; Cell Movement ; Cell Proliferation ; Cellular signal transduction ; Colorectal cancer ; Complications and side effects ; Female ; Follow-Up Studies ; Gastric cancer ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Health aspects ; Humans ; invasion ; JAK1/STAT3 ; Janus Kinase 1 - antagonists & inhibitors ; Janus Kinase 1 - genetics ; Janus Kinase 1 - metabolism ; Kinases ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - prevention & control ; Liver Neoplasms - secondary ; Lymphatic Metastasis ; Male ; Medical prognosis ; Metastasis ; Mice ; Mice, Nude ; MicroRNA ; MicroRNAs - genetics ; Middle Aged ; migration ; miR-448 ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - prevention & control ; Ovarian cancer ; Pancreatic cancer ; pancreatic ductal adenocarcinoma ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - prevention & control ; Prognosis ; Proteins ; Risk factors ; STAT3 Transcription Factor - antagonists & inhibitors ; STAT3 Transcription Factor - genetics ; STAT3 Transcription Factor - metabolism ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays]]></subject><ispartof>Oncology reports, 2017-08, Vol.38 (2), p.1075-1082</ispartof><rights>Copyright © 2017, Spandidos Publications</rights><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-429510681b90d2294cca98de2c2e3d6d7ab85ef4a4c0c88288658f963e8bcad63</citedby><cites>FETCH-LOGICAL-c486t-429510681b90d2294cca98de2c2e3d6d7ab85ef4a4c0c88288658f963e8bcad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28677798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Dan-Li</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Wu, Kun</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Li, Xiao-Quan</creatorcontrib><creatorcontrib>Peng, Xing-Guo</creatorcontrib><creatorcontrib>Wang, Jia-Ning</creatorcontrib><creatorcontrib>Tan, Li-Guo</creatorcontrib><title>MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>Pancreatic ductal adenocarcinoma (PDAC) is the most common type of malignant pancreatic tumor. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in tumorigenesis and progression of PDAC. In the present study, we demonstrated that miR-448 expression was downregulated in PDAC tissues and cell lines. Clinical association analysis indicated that low expression of miR-448 was associated with poor prognostic features and conferred a significant reduced survival of PDAC patients. Overexpression of miR-448 suppressed PDAC cell migration and invasion, while its loss showed the opposite effects on these cellular processes. In vivo experiments revealed that miR-488 restoration prohibited liver metastasis of PDAC in nude mice. Moreover, we found that Janus kinase 1 (JAK1) was a direct target gene of miR-448 in PDAC cells. We further demonstrated that the expression of JAK1 mRNA was upregulated in PDAC tissues. Notably, the expression of JAK1 mRNA was inversely correlated with the level of miR-448 in PDAC tissues. In addition, JAK1 knockdown showed similar effects of miR-448 on the metastasis of PDAC cells. JAK1/STAT3 pathway may be involved in the function of miR-448 in PDAC cells. Taken together, these findings suggest that miR-448 functions as a tumor suppressor in the development of PDAC through targeting the JAK1/STAT3 pathway.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - prevention & control</subject><subject>Adenocarcinoma - secondary</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biomarkers, Tumor</subject><subject>Cancer metastasis</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Carcinoma, Pancreatic Ductal - metabolism</subject><subject>Carcinoma, Pancreatic Ductal - prevention & control</subject><subject>Carcinoma, Pancreatic Ductal - secondary</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Cell adhesion & migration</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Cellular signal transduction</subject><subject>Colorectal cancer</subject><subject>Complications and side effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>invasion</subject><subject>JAK1/STAT3</subject><subject>Janus Kinase 1 - antagonists & inhibitors</subject><subject>Janus Kinase 1 - genetics</subject><subject>Janus Kinase 1 - metabolism</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - prevention & control</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>migration</subject><subject>miR-448</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Ovarian cancer</subject><subject>Pancreatic cancer</subject><subject>pancreatic ductal adenocarcinoma</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - prevention & control</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Risk factors</subject><subject>STAT3 Transcription Factor - antagonists & inhibitors</subject><subject>STAT3 Transcription Factor - genetics</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>Survival Rate</subject><subject>Tumor Cells, Cultured</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkttrFDEUxgdR7EXffJYBQXxwtrnMTJLHoXivCrqCb-FscmY3dWYyTTKU_vdmaW2tSAIJ4fednMP3FcUzSlZcKnbiw4oRKlaNkPRBcUiFohWrOX2Y74TRivPm50FxFOM5IUyQVj0uDphshRBKHha_PjsT_LcvXVXXsozLPAeMEWM5YoKYt4ul78sZJhMQkjOlXUyCoQSLkzcQjJv8CGXaBb9sd2WCsMXkpm35sftET76vuzXP6rS7hKsnxaMehohPb87j4sfbN-vT99XZ13cfTruzytSyTVXNVENJK-lGEcuYqo0BJS0yw5Db1grYyAb7GmpDjJRMyraRvWo5yo0B2_Lj4tV13Tn4iwVj0qOLBocBJvRL1FTRlktCicroi3_Qc7-EKXeXKVUrSRQRd9QWBtRu6n0KYPZFddcQrriglGRq9R8qL4ujM37C3uX3e4KXfwl2CEPaRT8syfkp3gdfX4PZqhgD9noOboRwpSnR-xBoH_Q-BHofgow_vxlq2Yxob-E_rt99HLOv1lkfbxkfKi4rwipKRMN_A3rGtlM</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Yu, Dan-Li</creator><creator>Zhang, Tao</creator><creator>Wu, Kun</creator><creator>Li, Yan</creator><creator>Wang, Juan</creator><creator>Chen, Jun</creator><creator>Li, Xiao-Quan</creator><creator>Peng, Xing-Guo</creator><creator>Wang, Jia-Ning</creator><creator>Tan, Li-Guo</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway</title><author>Yu, Dan-Li ; Zhang, Tao ; Wu, Kun ; Li, Yan ; Wang, Juan ; Chen, Jun ; Li, Xiao-Quan ; Peng, Xing-Guo ; Wang, Jia-Ning ; Tan, Li-Guo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-429510681b90d2294cca98de2c2e3d6d7ab85ef4a4c0c88288658f963e8bcad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - prevention & control</topic><topic>Adenocarcinoma - secondary</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biomarkers, Tumor</topic><topic>Cancer metastasis</topic><topic>Carcinoma, Pancreatic Ductal - genetics</topic><topic>Carcinoma, Pancreatic Ductal - metabolism</topic><topic>Carcinoma, Pancreatic Ductal - prevention & control</topic><topic>Carcinoma, Pancreatic Ductal - secondary</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Cell adhesion & migration</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Cellular signal transduction</topic><topic>Colorectal cancer</topic><topic>Complications and side effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>invasion</topic><topic>JAK1/STAT3</topic><topic>Janus Kinase 1 - antagonists & inhibitors</topic><topic>Janus Kinase 1 - genetics</topic><topic>Janus Kinase 1 - metabolism</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - prevention & control</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>MicroRNA</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>migration</topic><topic>miR-448</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Ovarian cancer</topic><topic>Pancreatic cancer</topic><topic>pancreatic ductal adenocarcinoma</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - prevention & control</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Risk factors</topic><topic>STAT3 Transcription Factor - antagonists & inhibitors</topic><topic>STAT3 Transcription Factor - genetics</topic><topic>STAT3 Transcription Factor - metabolism</topic><topic>Survival Rate</topic><topic>Tumor Cells, Cultured</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Dan-Li</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Wu, Kun</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Li, Xiao-Quan</creatorcontrib><creatorcontrib>Peng, Xing-Guo</creatorcontrib><creatorcontrib>Wang, Jia-Ning</creatorcontrib><creatorcontrib>Tan, Li-Guo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Dan-Li</au><au>Zhang, Tao</au><au>Wu, Kun</au><au>Li, Yan</au><au>Wang, Juan</au><au>Chen, Jun</au><au>Li, Xiao-Quan</au><au>Peng, Xing-Guo</au><au>Wang, Jia-Ning</au><au>Tan, Li-Guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>38</volume><issue>2</issue><spage>1075</spage><epage>1082</epage><pages>1075-1082</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>Pancreatic ductal adenocarcinoma (PDAC) is the most common type of malignant pancreatic tumor. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in tumorigenesis and progression of PDAC. In the present study, we demonstrated that miR-448 expression was downregulated in PDAC tissues and cell lines. Clinical association analysis indicated that low expression of miR-448 was associated with poor prognostic features and conferred a significant reduced survival of PDAC patients. Overexpression of miR-448 suppressed PDAC cell migration and invasion, while its loss showed the opposite effects on these cellular processes. In vivo experiments revealed that miR-488 restoration prohibited liver metastasis of PDAC in nude mice. Moreover, we found that Janus kinase 1 (JAK1) was a direct target gene of miR-448 in PDAC cells. We further demonstrated that the expression of JAK1 mRNA was upregulated in PDAC tissues. Notably, the expression of JAK1 mRNA was inversely correlated with the level of miR-448 in PDAC tissues. In addition, JAK1 knockdown showed similar effects of miR-448 on the metastasis of PDAC cells. JAK1/STAT3 pathway may be involved in the function of miR-448 in PDAC cells. Taken together, these findings suggest that miR-448 functions as a tumor suppressor in the development of PDAC through targeting the JAK1/STAT3 pathway.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>28677798</pmid><doi>10.3892/or.2017.5781</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncology reports, 2017-08, Vol.38 (2), p.1075-1082 |
| issn | 1021-335X 1791-2431 |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - prevention & control Adenocarcinoma - secondary Animals Apoptosis Biomarkers, Tumor Cancer metastasis Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - prevention & control Carcinoma, Pancreatic Ductal - secondary Care and treatment Case-Control Studies Cell adhesion & migration Cell Movement Cell Proliferation Cellular signal transduction Colorectal cancer Complications and side effects Female Follow-Up Studies Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans invasion JAK1/STAT3 Janus Kinase 1 - antagonists & inhibitors Janus Kinase 1 - genetics Janus Kinase 1 - metabolism Kinases Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - prevention & control Liver Neoplasms - secondary Lymphatic Metastasis Male Medical prognosis Metastasis Mice Mice, Nude MicroRNA MicroRNAs - genetics Middle Aged migration miR-448 Neoplasm Invasiveness Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - prevention & control Ovarian cancer Pancreatic cancer pancreatic ductal adenocarcinoma Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Neoplasms - prevention & control Prognosis Proteins Risk factors STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Survival Rate Tumor Cells, Cultured Xenograft Model Antitumor Assays |
| title | MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway |
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