Anaplastic lymphoma kinase expression and gene alterations in glioblastoma: correlations with clinical outcome

AimsTo study anaplastic lymphoma kinase (ALK) protein expression and possible underlying gene alterations in glioblastoma (GBM), correlating them with clinical outcome.MethodsWe studied ALK immunohistochemical expression and fluorescent in situ hybridisation (FISH)-detected ALK gene alterations in 5...

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Veröffentlicht in:	Journal of clinical pathology 2017-07, Vol.70 (7), p.593-599
Hauptverfasser:	Karagkounis, George, Stranjalis, George, Argyrakos, Theodore, Pantelaion, Varvara, Mastoris, Konstantinos, Rontogianni, Dimitra, Komaitis, Spyridon, Kalamatianos, Theodosis, Sakas, Damianos, Tiniakos, Dina
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Brain cancer Brain Neoplasms - enzymology Brain Neoplasms - genetics Brain Neoplasms - mortality Cell Proliferation Clinical outcomes Cloning Female Gangrene Glioblastoma - enzymology Glioblastoma - genetics Glioblastoma - mortality Humans In Situ Hybridization, Fluorescence Kaplan-Meier Estimate Kinases Lung cancer Lymphoma Male Middle Aged Mutation Mutation - genetics Neuroblastoma Prognosis Protein expression Proteins Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Retrospective Studies Tumors
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