Adhesive Photoswitch: Selective Photochemical Modulation of Enzymes under Physiological Conditions

We developed a water-soluble adhesive photoswitch (Glue n -Azo-SA, average n = 5) that selectively binds to a target enzyme and photochemically modulates its enzymatic activity even in cell lysates. Its design strategy features a photochromic azobenzene unit (Azo), which carries on one side an inhib...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-07, Vol.139 (29), p.10072-10078
Hauptverfasser:	Mogaki, Rina, Okuro, Kou, Aida, Takuzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesives - chemistry Adhesives - pharmacology Azo Compounds - chemistry Azo Compounds - pharmacology Binding Sites - drug effects Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - metabolism Guanidine - chemistry Guanidine - pharmacology Molecular Structure Photochemical Processes Solubility Sulfonamides - chemistry Sulfonamides - pharmacology Surface Properties Water - chemistry
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