Microneedles enhance topical delivery of 15-deoxy-Δ12,14-prostaglandin J2 and reduce nociception in temporomandibular joint of rats

The pain arising from temporomandibular disorders is often treated with opioids and agents that inhibit the immune response and are associated with substantial adverse effects and long-term risks. Thus, the development of new therapies that are safer and more effective is of great interest to patien...

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Veröffentlicht in:Journal of controlled release 2017-11, Vol.265, p.22-29
Hauptverfasser: Macedo, Cristina G., Jain, Amit K., Franz-Montan, Michelle, Napimoga, Marcelo H., Clemente-Napimoga, Juliana T., Gill, Harvinder Singh
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Sprache:eng
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