Benzyl isothiocyanate (BITC) induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells via activation of caspase-8/Bid and the reactive oxygen species-dependent mitochondrial pathway

ABSTRACT Benzyl isothiocyanate (BITC) is one of member of the isothiocyanate family which has been shown to induce cancer cell apoptosis in many human cancer cells. In the present study, we investigated the effects of BITC on the growth of GBM 8401 human brain glioblastoma multiforms cells. Results...

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Veröffentlicht in:	Environmental toxicology 2016-12, Vol.31 (12), p.1751-1760
Hauptverfasser:	Shang, Hung-Sheng, Shih, Yung-Luen, Lu, Tai-Jung, Lee, Ching-Hsiao, Hsueh, Shu-Ching, Chou, Yu-Cheng, Lu, Hsu-Feng, Liao, Nien-Chieh, Chung, Jing-Gung
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects BITC Brain Brain Neoplasms - drug therapy Caspase 3 - metabolism Caspase 8 - metabolism Caspase 9 - metabolism Caspase Inhibitors - pharmacology Cell Line, Tumor Enzyme Activation G1 Phase Cell Cycle Checkpoints - drug effects GBM 8401 human brain glioblastoma multiforms cells Glioblastoma - drug therapy Humans Isothiocyanates - pharmacology Membrane Potential, Mitochondrial - drug effects mitochondria Mitochondria - metabolism Oxygen Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism Rodents Signal Transduction - drug effects
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