Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer
Because of their great scientific and technological potentials, iron oxide nanoparticles (IONPs) have been the focus of extensive investigations in biomedicine over the past decade. Additionally, the surface plasmon resonance effect of gold nanoparticles (AuNPs) makes them a good candidate for photo...
Gespeichert in:
| Veröffentlicht in: | Lasers in medical science 2017-09, Vol.32 (7), p.1469-1477 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1477 |
|---|---|
| container_issue | 7 |
| container_start_page | 1469 |
| container_title | Lasers in medical science |
| container_volume | 32 |
| creator | Eyvazzadeh, Nazila Shakeri-Zadeh, Ali Fekrazad, Reza Amini, Elahe Ghaznavi, Habib Kamran Kamrava, S. |
| description | Because of their great scientific and technological potentials, iron oxide nanoparticles (IONPs) have been the focus of extensive investigations in biomedicine over the past decade. Additionally, the surface plasmon resonance effect of gold nanoparticles (AuNPs) makes them a good candidate for photothermal therapy applications. The unique properties of both IONPs (magnetic) and AuNPs (surface plasmon resonance) may lead to the development of a multi-modal nanoplatform to be used as a magnetic resonance imaging (MRI) contrast agent and as a nanoheater for photothermal therapy. Herein, core–shell gold-coated IONPs (Au@IONPs) were synthesized and investigated as an MRI contrast agent and as a light-responsive agent for cancer photothermal therapy.
The synthesized Au@IONPs were characterized by UV–visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential analysis. The transverse relaxivity (
r
2
) of the Au@IONPs was measured using a 3-T clinical MRI scanner. Through a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the cytotoxicity of the Au@IONs was examined on a KB cell line, derived from the epidermal carcinoma of a human mouth. Moreover, the photothermal effects of Au@IONPs in the presence of a laser beam (λ = 808 nm; 6.3 W/cm
2
; 5 min) were studied.
The results show that the Au@IONPs are spherical with a hydrodynamic size of 33 nm. A transverse relaxivity of 95 mM
−1
S
−1
was measured for the synthesized Au@IONPs. It is evident from the MTT results that no significant cytotoxicity in KB cells occurs with Au@IONPs. Additionally, no significant cell damage induced by the laser is observed. Following the photothermal treatment using Au@IONPs, approximately 70% cell death is achieved. It is found that cell lethality depended strongly on incubation period and the Au@IONP concentration.
The data highlight the potential of Au@IONPs as a dual-function MRI contrast agent and photosensitizer for cancer photothermal therapy. |
| doi_str_mv | 10.1007/s10103-017-2267-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1915881189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1915881189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-ada45238650625e8134bae0deb23a209c87a1d4daec04d64132015443a7d9bc3</originalsourceid><addsrcrecordid>eNp1kU9PGzEQxa2qCFLKB-ilstQLF4PH9u56jwgVWgmJC4ferIk9CUEbe7E3Elz47HUS-kdInMaa-b1njx9jX0CegZTdeQEJUgsJnVCq7cTTBzYDoxvRSvPrI5tJ1VphewVH7FMpD7KCLehDdqRs25nO9jP2cp2GIHzCiQJf4zLStPI8Ykwj5nociGPhuOtM95RrKVsClxQnvkj5nyhTSRXzxFe1t4pLjjHw8T5NO-UaB75zGJ95WnC_JfNndrDAodDJaz1md1ff7y5_iJvb65-XFzfCG20ngQFNo7RtG9mqhixoM0eSgeZKo5K9tx1CMAHJSxNaA1pJaIzR2IV-7vUxO93bjjk9bqhMbr0qnoYBI6VNcdBDYy2A7Sv67Q36kDY51sdVSistdWdkpWBP-ZxKybRwY65b52cH0m2zcftsXP1yt83GPVXN11fnzXxN4a_iTxgVUHug1FFcUv7v6nddfwOlQJu_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932303740</pqid></control><display><type>article</type><title>Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Eyvazzadeh, Nazila ; Shakeri-Zadeh, Ali ; Fekrazad, Reza ; Amini, Elahe ; Ghaznavi, Habib ; Kamran Kamrava, S.</creator><creatorcontrib>Eyvazzadeh, Nazila ; Shakeri-Zadeh, Ali ; Fekrazad, Reza ; Amini, Elahe ; Ghaznavi, Habib ; Kamran Kamrava, S.</creatorcontrib><description>Because of their great scientific and technological potentials, iron oxide nanoparticles (IONPs) have been the focus of extensive investigations in biomedicine over the past decade. Additionally, the surface plasmon resonance effect of gold nanoparticles (AuNPs) makes them a good candidate for photothermal therapy applications. The unique properties of both IONPs (magnetic) and AuNPs (surface plasmon resonance) may lead to the development of a multi-modal nanoplatform to be used as a magnetic resonance imaging (MRI) contrast agent and as a nanoheater for photothermal therapy. Herein, core–shell gold-coated IONPs (Au@IONPs) were synthesized and investigated as an MRI contrast agent and as a light-responsive agent for cancer photothermal therapy.
The synthesized Au@IONPs were characterized by UV–visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential analysis. The transverse relaxivity (
r
2
) of the Au@IONPs was measured using a 3-T clinical MRI scanner. Through a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the cytotoxicity of the Au@IONs was examined on a KB cell line, derived from the epidermal carcinoma of a human mouth. Moreover, the photothermal effects of Au@IONPs in the presence of a laser beam (λ = 808 nm; 6.3 W/cm
2
; 5 min) were studied.
The results show that the Au@IONPs are spherical with a hydrodynamic size of 33 nm. A transverse relaxivity of 95 mM
−1
S
−1
was measured for the synthesized Au@IONPs. It is evident from the MTT results that no significant cytotoxicity in KB cells occurs with Au@IONPs. Additionally, no significant cell damage induced by the laser is observed. Following the photothermal treatment using Au@IONPs, approximately 70% cell death is achieved. It is found that cell lethality depended strongly on incubation period and the Au@IONP concentration.
The data highlight the potential of Au@IONPs as a dual-function MRI contrast agent and photosensitizer for cancer photothermal therapy.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-017-2267-x</identifier><identifier>PMID: 28674789</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Biocompatibility ; Cancer ; Cell death ; Cell Line, Tumor ; Cell Survival ; Cytotoxicity ; Dentistry ; Electron microscopy ; Gold ; Gold - chemistry ; Humans ; Hyperthermia, Induced - methods ; Iron ; Iron oxides ; KB cells ; Laser beams ; Laser damage ; Lasers ; Lethality ; Light scattering ; Magnetic properties ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Magnetite Nanoparticles - chemistry ; Magnetite Nanoparticles - ultrastructure ; Medicine ; Medicine & Public Health ; Microscopy, Electron, Transmission ; Nanoparticles ; Neoplasms - therapy ; NMR ; Nuclear magnetic resonance ; Optical Devices ; Optics ; Original Article ; Particle Size ; Photodynamic therapy ; Photon correlation spectroscopy ; Photonics ; Phototherapy - methods ; Quantum Optics ; Resonance ; Spectrophotometry, Ultraviolet ; Spectroscopy ; Surface plasmon resonance ; Synthesis ; Theranostic Nanomedicine ; Therapy ; Toxicity ; Transmission electron microscopy ; Zeta potential</subject><ispartof>Lasers in medical science, 2017-09, Vol.32 (7), p.1469-1477</ispartof><rights>Springer-Verlag London Ltd. 2017</rights><rights>Lasers in Medical Science is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ada45238650625e8134bae0deb23a209c87a1d4daec04d64132015443a7d9bc3</citedby><cites>FETCH-LOGICAL-c438t-ada45238650625e8134bae0deb23a209c87a1d4daec04d64132015443a7d9bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-017-2267-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-017-2267-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28674789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eyvazzadeh, Nazila</creatorcontrib><creatorcontrib>Shakeri-Zadeh, Ali</creatorcontrib><creatorcontrib>Fekrazad, Reza</creatorcontrib><creatorcontrib>Amini, Elahe</creatorcontrib><creatorcontrib>Ghaznavi, Habib</creatorcontrib><creatorcontrib>Kamran Kamrava, S.</creatorcontrib><title>Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>Because of their great scientific and technological potentials, iron oxide nanoparticles (IONPs) have been the focus of extensive investigations in biomedicine over the past decade. Additionally, the surface plasmon resonance effect of gold nanoparticles (AuNPs) makes them a good candidate for photothermal therapy applications. The unique properties of both IONPs (magnetic) and AuNPs (surface plasmon resonance) may lead to the development of a multi-modal nanoplatform to be used as a magnetic resonance imaging (MRI) contrast agent and as a nanoheater for photothermal therapy. Herein, core–shell gold-coated IONPs (Au@IONPs) were synthesized and investigated as an MRI contrast agent and as a light-responsive agent for cancer photothermal therapy.
The synthesized Au@IONPs were characterized by UV–visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential analysis. The transverse relaxivity (
r
2
) of the Au@IONPs was measured using a 3-T clinical MRI scanner. Through a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the cytotoxicity of the Au@IONs was examined on a KB cell line, derived from the epidermal carcinoma of a human mouth. Moreover, the photothermal effects of Au@IONPs in the presence of a laser beam (λ = 808 nm; 6.3 W/cm
2
; 5 min) were studied.
The results show that the Au@IONPs are spherical with a hydrodynamic size of 33 nm. A transverse relaxivity of 95 mM
−1
S
−1
was measured for the synthesized Au@IONPs. It is evident from the MTT results that no significant cytotoxicity in KB cells occurs with Au@IONPs. Additionally, no significant cell damage induced by the laser is observed. Following the photothermal treatment using Au@IONPs, approximately 70% cell death is achieved. It is found that cell lethality depended strongly on incubation period and the Au@IONP concentration.
The data highlight the potential of Au@IONPs as a dual-function MRI contrast agent and photosensitizer for cancer photothermal therapy.</description><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival</subject><subject>Cytotoxicity</subject><subject>Dentistry</subject><subject>Electron microscopy</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Iron</subject><subject>Iron oxides</subject><subject>KB cells</subject><subject>Laser beams</subject><subject>Laser damage</subject><subject>Lasers</subject><subject>Lethality</subject><subject>Light scattering</subject><subject>Magnetic properties</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Magnetite Nanoparticles - ultrastructure</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nanoparticles</subject><subject>Neoplasms - therapy</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Particle Size</subject><subject>Photodynamic therapy</subject><subject>Photon correlation spectroscopy</subject><subject>Photonics</subject><subject>Phototherapy - methods</subject><subject>Quantum Optics</subject><subject>Resonance</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Spectroscopy</subject><subject>Surface plasmon resonance</subject><subject>Synthesis</subject><subject>Theranostic Nanomedicine</subject><subject>Therapy</subject><subject>Toxicity</subject><subject>Transmission electron microscopy</subject><subject>Zeta potential</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9PGzEQxa2qCFLKB-ilstQLF4PH9u56jwgVWgmJC4ferIk9CUEbe7E3Elz47HUS-kdInMaa-b1njx9jX0CegZTdeQEJUgsJnVCq7cTTBzYDoxvRSvPrI5tJ1VphewVH7FMpD7KCLehDdqRs25nO9jP2cp2GIHzCiQJf4zLStPI8Ykwj5nociGPhuOtM95RrKVsClxQnvkj5nyhTSRXzxFe1t4pLjjHw8T5NO-UaB75zGJ95WnC_JfNndrDAodDJaz1md1ff7y5_iJvb65-XFzfCG20ngQFNo7RtG9mqhixoM0eSgeZKo5K9tx1CMAHJSxNaA1pJaIzR2IV-7vUxO93bjjk9bqhMbr0qnoYBI6VNcdBDYy2A7Sv67Q36kDY51sdVSistdWdkpWBP-ZxKybRwY65b52cH0m2zcftsXP1yt83GPVXN11fnzXxN4a_iTxgVUHug1FFcUv7v6nddfwOlQJu_</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Eyvazzadeh, Nazila</creator><creator>Shakeri-Zadeh, Ali</creator><creator>Fekrazad, Reza</creator><creator>Amini, Elahe</creator><creator>Ghaznavi, Habib</creator><creator>Kamran Kamrava, S.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer</title><author>Eyvazzadeh, Nazila ; Shakeri-Zadeh, Ali ; Fekrazad, Reza ; Amini, Elahe ; Ghaznavi, Habib ; Kamran Kamrava, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-ada45238650625e8134bae0deb23a209c87a1d4daec04d64132015443a7d9bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival</topic><topic>Cytotoxicity</topic><topic>Dentistry</topic><topic>Electron microscopy</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>Iron</topic><topic>Iron oxides</topic><topic>KB cells</topic><topic>Laser beams</topic><topic>Laser damage</topic><topic>Lasers</topic><topic>Lethality</topic><topic>Light scattering</topic><topic>Magnetic properties</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Magnetite Nanoparticles - ultrastructure</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nanoparticles</topic><topic>Neoplasms - therapy</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Original Article</topic><topic>Particle Size</topic><topic>Photodynamic therapy</topic><topic>Photon correlation spectroscopy</topic><topic>Photonics</topic><topic>Phototherapy - methods</topic><topic>Quantum Optics</topic><topic>Resonance</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Spectroscopy</topic><topic>Surface plasmon resonance</topic><topic>Synthesis</topic><topic>Theranostic Nanomedicine</topic><topic>Therapy</topic><topic>Toxicity</topic><topic>Transmission electron microscopy</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eyvazzadeh, Nazila</creatorcontrib><creatorcontrib>Shakeri-Zadeh, Ali</creatorcontrib><creatorcontrib>Fekrazad, Reza</creatorcontrib><creatorcontrib>Amini, Elahe</creatorcontrib><creatorcontrib>Ghaznavi, Habib</creatorcontrib><creatorcontrib>Kamran Kamrava, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eyvazzadeh, Nazila</au><au>Shakeri-Zadeh, Ali</au><au>Fekrazad, Reza</au><au>Amini, Elahe</au><au>Ghaznavi, Habib</au><au>Kamran Kamrava, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>32</volume><issue>7</issue><spage>1469</spage><epage>1477</epage><pages>1469-1477</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>Because of their great scientific and technological potentials, iron oxide nanoparticles (IONPs) have been the focus of extensive investigations in biomedicine over the past decade. Additionally, the surface plasmon resonance effect of gold nanoparticles (AuNPs) makes them a good candidate for photothermal therapy applications. The unique properties of both IONPs (magnetic) and AuNPs (surface plasmon resonance) may lead to the development of a multi-modal nanoplatform to be used as a magnetic resonance imaging (MRI) contrast agent and as a nanoheater for photothermal therapy. Herein, core–shell gold-coated IONPs (Au@IONPs) were synthesized and investigated as an MRI contrast agent and as a light-responsive agent for cancer photothermal therapy.
The synthesized Au@IONPs were characterized by UV–visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential analysis. The transverse relaxivity (
r
2
) of the Au@IONPs was measured using a 3-T clinical MRI scanner. Through a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the cytotoxicity of the Au@IONs was examined on a KB cell line, derived from the epidermal carcinoma of a human mouth. Moreover, the photothermal effects of Au@IONPs in the presence of a laser beam (λ = 808 nm; 6.3 W/cm
2
; 5 min) were studied.
The results show that the Au@IONPs are spherical with a hydrodynamic size of 33 nm. A transverse relaxivity of 95 mM
−1
S
−1
was measured for the synthesized Au@IONPs. It is evident from the MTT results that no significant cytotoxicity in KB cells occurs with Au@IONPs. Additionally, no significant cell damage induced by the laser is observed. Following the photothermal treatment using Au@IONPs, approximately 70% cell death is achieved. It is found that cell lethality depended strongly on incubation period and the Au@IONP concentration.
The data highlight the potential of Au@IONPs as a dual-function MRI contrast agent and photosensitizer for cancer photothermal therapy.</abstract><cop>London</cop><pub>Springer London</pub><pmid>28674789</pmid><doi>10.1007/s10103-017-2267-x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-8921 |
| ispartof | Lasers in medical science, 2017-09, Vol.32 (7), p.1469-1477 |
| issn | 0268-8921 1435-604X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1915881189 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biocompatibility Cancer Cell death Cell Line, Tumor Cell Survival Cytotoxicity Dentistry Electron microscopy Gold Gold - chemistry Humans Hyperthermia, Induced - methods Iron Iron oxides KB cells Laser beams Laser damage Lasers Lethality Light scattering Magnetic properties Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - ultrastructure Medicine Medicine & Public Health Microscopy, Electron, Transmission Nanoparticles Neoplasms - therapy NMR Nuclear magnetic resonance Optical Devices Optics Original Article Particle Size Photodynamic therapy Photon correlation spectroscopy Photonics Phototherapy - methods Quantum Optics Resonance Spectrophotometry, Ultraviolet Spectroscopy Surface plasmon resonance Synthesis Theranostic Nanomedicine Therapy Toxicity Transmission electron microscopy Zeta potential |
| title | Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A35%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gold-coated%20magnetic%20nanoparticle%20as%20a%20nanotheranostic%20agent%20for%20magnetic%20resonance%20imaging%20and%20photothermal%20therapy%20of%20cancer&rft.jtitle=Lasers%20in%20medical%20science&rft.au=Eyvazzadeh,%20Nazila&rft.date=2017-09-01&rft.volume=32&rft.issue=7&rft.spage=1469&rft.epage=1477&rft.pages=1469-1477&rft.issn=0268-8921&rft.eissn=1435-604X&rft_id=info:doi/10.1007/s10103-017-2267-x&rft_dat=%3Cproquest_cross%3E1915881189%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932303740&rft_id=info:pmid/28674789&rfr_iscdi=true |