Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster
The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis showed that Valerenic acid (1260.53 µg/g of extract) and Xanthohumol (Cascade: 827.49 µg/g, Hallertau: 763.60 µg/g, Saaz: 186.93 µg/g) were contained in Valerian and Hop,...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2017/07/01, Vol.40(7), pp.1101-1110 |
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| creator | Choi, Hyeon-Son Ko, Bong Soo Kim, Hae Dun Hong, Ki-Bae Suh, Hyung Joo |
| description | The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis showed that Valerenic acid (1260.53 µg/g of extract) and Xanthohumol (Cascade: 827.49 µg/g, Hallertau: 763.60 µg/g, Saaz: 186.93 µg/g) were contained in Valerian and Hop, respectively. The sleep patterns of fruit flies on the Valerian/Hops were examined in both baseline and caffeine-treated conditions. Total activities of flies significantly decreased in 20 mg/mL Valerian (74%), 10 mg/mL Cascade (25%), and 5 mg/mL Hallertau (11%) during nighttime or daytime compared with the control. Valerian/Cascade mixture showed longer sleeping time (ca. 20%) than control group. This mixture-mediated effect was partly observed in caffeine-treated flies. Valerian/Cascade mixture upregulated mRNA expressions of gamma-aminobutyric acid (GABA) receptors and serotonin receptor, and GABA receptors were more strongly regulated than serotonin receptor. In competitive GABA receptor binding assay, Valerian/Cascade mixture extract showed a higher binding ability on GABA receptor than Valerenic acid or/and Xanthohumol which are estimated to be active compounds in the extract. This study demonstrates that a Valerian/Cascade mixture extract improves sleep-related behaviors, including sleeping time, by modulating GABAergic/serotonergic signaling. |
| doi_str_mv | 10.1248/bpb.b17-00262 |
| format | Article |
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The HPLC analysis showed that Valerenic acid (1260.53 µg/g of extract) and Xanthohumol (Cascade: 827.49 µg/g, Hallertau: 763.60 µg/g, Saaz: 186.93 µg/g) were contained in Valerian and Hop, respectively. The sleep patterns of fruit flies on the Valerian/Hops were examined in both baseline and caffeine-treated conditions. Total activities of flies significantly decreased in 20 mg/mL Valerian (74%), 10 mg/mL Cascade (25%), and 5 mg/mL Hallertau (11%) during nighttime or daytime compared with the control. Valerian/Cascade mixture showed longer sleeping time (ca. 20%) than control group. This mixture-mediated effect was partly observed in caffeine-treated flies. Valerian/Cascade mixture upregulated mRNA expressions of gamma-aminobutyric acid (GABA) receptors and serotonin receptor, and GABA receptors were more strongly regulated than serotonin receptor. In competitive GABA receptor binding assay, Valerian/Cascade mixture extract showed a higher binding ability on GABA receptor than Valerenic acid or/and Xanthohumol which are estimated to be active compounds in the extract. This study demonstrates that a Valerian/Cascade mixture extract improves sleep-related behaviors, including sleeping time, by modulating GABAergic/serotonergic signaling.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b17-00262</identifier><identifier>PMID: 28674253</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Assaying ; Caffeine ; Daytime ; Drosophila melanogaster ; Drosophila melanogaster - physiology ; Fruit flies ; Fruits ; High-performance liquid chromatography ; Hop ; Hops ; Humulus ; insomnia ; Liquid chromatography ; mRNA ; Nighttime ; Protein Binding ; Receptors, GABA - genetics ; Receptors, GABA - metabolism ; Receptors, Serotonin - genetics ; Receptors, Serotonin - metabolism ; RNA, Messenger - genetics ; Serotonin ; Sleep ; sleep-promotion ; Up-Regulation ; Valerian ; Xanthohumol ; γ-Aminobutyric acid receptors</subject><ispartof>Biological and Pharmaceutical Bulletin, 2017/07/01, Vol.40(7), pp.1101-1110</ispartof><rights>2017 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-812a58da503083cfc1b1a2dedea2e60a8471adb2f88a879374ef2cfda41b58c63</citedby><cites>FETCH-LOGICAL-c702t-812a58da503083cfc1b1a2dedea2e60a8471adb2f88a879374ef2cfda41b58c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28674253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Hyeon-Son</creatorcontrib><creatorcontrib>Ko, Bong Soo</creatorcontrib><creatorcontrib>Kim, Hae Dun</creatorcontrib><creatorcontrib>Hong, Ki-Bae</creatorcontrib><creatorcontrib>Suh, Hyung Joo</creatorcontrib><creatorcontrib>Korea University</creatorcontrib><creatorcontrib>Namyang Dairy Products Corporation</creatorcontrib><creatorcontrib>aDepartment of Food Science and Technology</creatorcontrib><creatorcontrib>dDepartment of Biological Sciences and Environmental Science Program</creatorcontrib><creatorcontrib>Seoul Women's University</creatorcontrib><creatorcontrib>bResearch and Development Center</creatorcontrib><creatorcontrib>cDepartment of Public Health Sciences</creatorcontrib><creatorcontrib>Southern Illinois University-Edwardsville</creatorcontrib><title>Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis showed that Valerenic acid (1260.53 µg/g of extract) and Xanthohumol (Cascade: 827.49 µg/g, Hallertau: 763.60 µg/g, Saaz: 186.93 µg/g) were contained in Valerian and Hop, respectively. The sleep patterns of fruit flies on the Valerian/Hops were examined in both baseline and caffeine-treated conditions. Total activities of flies significantly decreased in 20 mg/mL Valerian (74%), 10 mg/mL Cascade (25%), and 5 mg/mL Hallertau (11%) during nighttime or daytime compared with the control. Valerian/Cascade mixture showed longer sleeping time (ca. 20%) than control group. This mixture-mediated effect was partly observed in caffeine-treated flies. Valerian/Cascade mixture upregulated mRNA expressions of gamma-aminobutyric acid (GABA) receptors and serotonin receptor, and GABA receptors were more strongly regulated than serotonin receptor. In competitive GABA receptor binding assay, Valerian/Cascade mixture extract showed a higher binding ability on GABA receptor than Valerenic acid or/and Xanthohumol which are estimated to be active compounds in the extract. This study demonstrates that a Valerian/Cascade mixture extract improves sleep-related behaviors, including sleeping time, by modulating GABAergic/serotonergic signaling.</description><subject>Animals</subject><subject>Assaying</subject><subject>Caffeine</subject><subject>Daytime</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - physiology</subject><subject>Fruit flies</subject><subject>Fruits</subject><subject>High-performance liquid chromatography</subject><subject>Hop</subject><subject>Hops</subject><subject>Humulus</subject><subject>insomnia</subject><subject>Liquid chromatography</subject><subject>mRNA</subject><subject>Nighttime</subject><subject>Protein Binding</subject><subject>Receptors, GABA - genetics</subject><subject>Receptors, GABA - metabolism</subject><subject>Receptors, Serotonin - genetics</subject><subject>Receptors, Serotonin - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>Serotonin</subject><subject>Sleep</subject><subject>sleep-promotion</subject><subject>Up-Regulation</subject><subject>Valerian</subject><subject>Xanthohumol</subject><subject>γ-Aminobutyric acid receptors</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1v1DAQxS0EosuWI1cUiQuXtB7nw84RltJWalUJWq7WxJl0vfLGwU4Q_Pd4d9tF4jI-zE_vvXlm7B3wMxClOm_H9qwFmXMuavGCLaAoZV4JqF6yBW9A5TVU6oS9iXHDOZdcFK_ZiVC1LEVVLNj9Rd-TmTLfZz_QUbA4nF_5Mbu1v6c5UOaH7LsjGvNv5HCiLvtMa_xlfYiZHbIvwUc_rq3DbJv2g3_EOFE4Za96dJHePr1L9vD14n51ld_cXV6vPt3kJuWYcgUCK9VhxQuuCtMbaAFFRx2hoJqjKiVg14peKVSyKWRJvTB9hyW0lTJ1sWQfD7pj8D9nipPe2mjIpSTk56ihSbcrgHT0kn34D934OQwp3Y6qeVOndhKVHyiTDouBej0Gu8XwRwPXu7p1qlunuvW-7sS_f1Kd2y11R_q53wRcHoC0tQadH5wd6J-3ibK13nkt-F60TF-kuUhmwCGNFL3hVQ07q9VBaRMnfKSjFYbJGkf7YCXXcjeOAY9bs8agaSj-AnN9qNY</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Choi, Hyeon-Son</creator><creator>Ko, Bong Soo</creator><creator>Kim, Hae Dun</creator><creator>Hong, Ki-Bae</creator><creator>Suh, Hyung Joo</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster</title><author>Choi, Hyeon-Son ; Ko, Bong Soo ; Kim, Hae Dun ; Hong, Ki-Bae ; Suh, Hyung Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-812a58da503083cfc1b1a2dedea2e60a8471adb2f88a879374ef2cfda41b58c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Assaying</topic><topic>Caffeine</topic><topic>Daytime</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - physiology</topic><topic>Fruit flies</topic><topic>Fruits</topic><topic>High-performance liquid chromatography</topic><topic>Hop</topic><topic>Hops</topic><topic>Humulus</topic><topic>insomnia</topic><topic>Liquid chromatography</topic><topic>mRNA</topic><topic>Nighttime</topic><topic>Protein Binding</topic><topic>Receptors, GABA - genetics</topic><topic>Receptors, GABA - metabolism</topic><topic>Receptors, Serotonin - genetics</topic><topic>Receptors, Serotonin - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>Serotonin</topic><topic>Sleep</topic><topic>sleep-promotion</topic><topic>Up-Regulation</topic><topic>Valerian</topic><topic>Xanthohumol</topic><topic>γ-Aminobutyric acid receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Hyeon-Son</creatorcontrib><creatorcontrib>Ko, Bong Soo</creatorcontrib><creatorcontrib>Kim, Hae Dun</creatorcontrib><creatorcontrib>Hong, Ki-Bae</creatorcontrib><creatorcontrib>Suh, Hyung Joo</creatorcontrib><creatorcontrib>Korea University</creatorcontrib><creatorcontrib>Namyang Dairy Products Corporation</creatorcontrib><creatorcontrib>aDepartment of Food Science and Technology</creatorcontrib><creatorcontrib>dDepartment of Biological Sciences and Environmental Science Program</creatorcontrib><creatorcontrib>Seoul Women's University</creatorcontrib><creatorcontrib>bResearch and Development Center</creatorcontrib><creatorcontrib>cDepartment of Public Health Sciences</creatorcontrib><creatorcontrib>Southern Illinois University-Edwardsville</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Hyeon-Son</au><au>Ko, Bong Soo</au><au>Kim, Hae Dun</au><au>Hong, Ki-Bae</au><au>Suh, Hyung Joo</au><aucorp>Korea University</aucorp><aucorp>Namyang Dairy Products Corporation</aucorp><aucorp>aDepartment of Food Science and Technology</aucorp><aucorp>dDepartment of Biological Sciences and Environmental Science Program</aucorp><aucorp>Seoul Women's University</aucorp><aucorp>bResearch and Development Center</aucorp><aucorp>cDepartment of Public Health Sciences</aucorp><aucorp>Southern Illinois University-Edwardsville</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2017</date><risdate>2017</risdate><volume>40</volume><issue>7</issue><spage>1101</spage><epage>1110</epage><pages>1101-1110</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis showed that Valerenic acid (1260.53 µg/g of extract) and Xanthohumol (Cascade: 827.49 µg/g, Hallertau: 763.60 µg/g, Saaz: 186.93 µg/g) were contained in Valerian and Hop, respectively. The sleep patterns of fruit flies on the Valerian/Hops were examined in both baseline and caffeine-treated conditions. Total activities of flies significantly decreased in 20 mg/mL Valerian (74%), 10 mg/mL Cascade (25%), and 5 mg/mL Hallertau (11%) during nighttime or daytime compared with the control. Valerian/Cascade mixture showed longer sleeping time (ca. 20%) than control group. This mixture-mediated effect was partly observed in caffeine-treated flies. Valerian/Cascade mixture upregulated mRNA expressions of gamma-aminobutyric acid (GABA) receptors and serotonin receptor, and GABA receptors were more strongly regulated than serotonin receptor. In competitive GABA receptor binding assay, Valerian/Cascade mixture extract showed a higher binding ability on GABA receptor than Valerenic acid or/and Xanthohumol which are estimated to be active compounds in the extract. This study demonstrates that a Valerian/Cascade mixture extract improves sleep-related behaviors, including sleeping time, by modulating GABAergic/serotonergic signaling.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>28674253</pmid><doi>10.1248/bpb.b17-00262</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Assaying Caffeine Daytime Drosophila melanogaster Drosophila melanogaster - physiology Fruit flies Fruits High-performance liquid chromatography Hop Hops Humulus insomnia Liquid chromatography mRNA Nighttime Protein Binding Receptors, GABA - genetics Receptors, GABA - metabolism Receptors, Serotonin - genetics Receptors, Serotonin - metabolism RNA, Messenger - genetics Serotonin Sleep sleep-promotion Up-Regulation Valerian Xanthohumol γ-Aminobutyric acid receptors |
| title | Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster |
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