Resistant phenotypes of Escherichia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo
Urinary tract infection caused by Escherichia coli frequently occurs in the hospital environment. This study aims to describe resistant phenotypes of Escherichia coli strains to monitor their occurrence. We conducted a descriptive retrospective study of 102 Escherchia coli strains responsible for ur...
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| Veröffentlicht in: | The Pan African medical journal 2017, Vol.26, p.166-166 |
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| creator | Rakotovao-Ravahatra, Zafindrasoa Domoina Randriatsarafara, Fidiniaina Mamy Rasoanandrasana, Saïda Raverohanta, Léa Rakotovao, Andriamiadana Luc |
| description | Urinary tract infection caused by Escherichia coli frequently occurs in the hospital environment. This study aims to describe resistant phenotypes of Escherichia coli strains to monitor their occurrence.
We conducted a descriptive retrospective study of 102 Escherchia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo from January 2014 to October 2016.
Beta-lactam antibiotic resistance screening identified high-level penicillinases 50% (n=51), Escherichia coli producing extended-spectrum beta-lactamases (ESBLs) 22.5% (n=23), high-level cephalosporinases 14.7% (n=15), penicillinases low level 5.9% (n=6), wild type strains 5.9% (n=6) and a strain ofEscherichia coli emerging strain high-level resistance. Aminoglycosides resistance was identified in 58 (56.9%) wild type phenotype, 29 (28.4%) strains sensitive to amikacin and 15 (14.7%) resistant to all aminoglycosides. Fluoroquinolones resistance was identified in 52 (51%) wild type strains, 9 (8.8%) strains sensitive to ciprofloxacin and 41 (40.2%) resistant to all fluoroquinolones. Women (25, 7%) (p= 0.25, NS), patients more than 60 years (38.7%) (p=0.02), patients hospitalized in the Department of Nephrology (53.8%) (p=0.04), with urinary disorder and kidney disease (29, 7%) (p= 0.2, NS) were the most affected by E-ESBL.
Based on high multidrug resistance in Escherichia coli strains guidelines for the empirical treatment of urinary tract infections need to be revised. |
| doi_str_mv | 10.11604/pamj.2017.26.166.11828 |
| format | Article |
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We conducted a descriptive retrospective study of 102 Escherchia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo from January 2014 to October 2016.
Beta-lactam antibiotic resistance screening identified high-level penicillinases 50% (n=51), Escherichia coli producing extended-spectrum beta-lactamases (ESBLs) 22.5% (n=23), high-level cephalosporinases 14.7% (n=15), penicillinases low level 5.9% (n=6), wild type strains 5.9% (n=6) and a strain ofEscherichia coli emerging strain high-level resistance. Aminoglycosides resistance was identified in 58 (56.9%) wild type phenotype, 29 (28.4%) strains sensitive to amikacin and 15 (14.7%) resistant to all aminoglycosides. Fluoroquinolones resistance was identified in 52 (51%) wild type strains, 9 (8.8%) strains sensitive to ciprofloxacin and 41 (40.2%) resistant to all fluoroquinolones. Women (25, 7%) (p= 0.25, NS), patients more than 60 years (38.7%) (p=0.02), patients hospitalized in the Department of Nephrology (53.8%) (p=0.04), with urinary disorder and kidney disease (29, 7%) (p= 0.2, NS) were the most affected by E-ESBL.
Based on high multidrug resistance in Escherichia coli strains guidelines for the empirical treatment of urinary tract infections need to be revised.</description><identifier>EISSN: 1937-8688</identifier><identifier>DOI: 10.11604/pamj.2017.26.166.11828</identifier><identifier>PMID: 28674559</identifier><language>fre</language><publisher>Uganda</publisher><subject>Adolescent ; Adult ; Ageism ; Anti-Bacterial Agents - pharmacology ; Child ; Child, Preschool ; Drug Resistance, Multiple, Bacterial ; Escherichia coli - drug effects ; Escherichia coli - isolation & purification ; Escherichia coli Infections - drug therapy ; Escherichia coli Infections - epidemiology ; Escherichia coli Infections - microbiology ; Female ; Hospitalization ; Hospitals, University ; Humans ; Infant ; Madagascar - epidemiology ; Male ; Middle Aged ; Phenotype ; Retrospective Studies ; Sex Distribution ; Urinary Tract Infections - drug therapy ; Urinary Tract Infections - epidemiology ; Urinary Tract Infections - microbiology ; Young Adult</subject><ispartof>The Pan African medical journal, 2017, Vol.26, p.166-166</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28674559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rakotovao-Ravahatra, Zafindrasoa Domoina</creatorcontrib><creatorcontrib>Randriatsarafara, Fidiniaina Mamy</creatorcontrib><creatorcontrib>Rasoanandrasana, Saïda</creatorcontrib><creatorcontrib>Raverohanta, Léa</creatorcontrib><creatorcontrib>Rakotovao, Andriamiadana Luc</creatorcontrib><title>Resistant phenotypes of Escherichia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo</title><title>The Pan African medical journal</title><addtitle>Pan Afr Med J</addtitle><description>Urinary tract infection caused by Escherichia coli frequently occurs in the hospital environment. This study aims to describe resistant phenotypes of Escherichia coli strains to monitor their occurrence.
We conducted a descriptive retrospective study of 102 Escherchia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo from January 2014 to October 2016.
Beta-lactam antibiotic resistance screening identified high-level penicillinases 50% (n=51), Escherichia coli producing extended-spectrum beta-lactamases (ESBLs) 22.5% (n=23), high-level cephalosporinases 14.7% (n=15), penicillinases low level 5.9% (n=6), wild type strains 5.9% (n=6) and a strain ofEscherichia coli emerging strain high-level resistance. Aminoglycosides resistance was identified in 58 (56.9%) wild type phenotype, 29 (28.4%) strains sensitive to amikacin and 15 (14.7%) resistant to all aminoglycosides. Fluoroquinolones resistance was identified in 52 (51%) wild type strains, 9 (8.8%) strains sensitive to ciprofloxacin and 41 (40.2%) resistant to all fluoroquinolones. Women (25, 7%) (p= 0.25, NS), patients more than 60 years (38.7%) (p=0.02), patients hospitalized in the Department of Nephrology (53.8%) (p=0.04), with urinary disorder and kidney disease (29, 7%) (p= 0.2, NS) were the most affected by E-ESBL.
Based on high multidrug resistance in Escherichia coli strains guidelines for the empirical treatment of urinary tract infections need to be revised.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Ageism</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli Infections - drug therapy</subject><subject>Escherichia coli Infections - epidemiology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Infant</subject><subject>Madagascar - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Retrospective Studies</subject><subject>Sex Distribution</subject><subject>Urinary Tract Infections - drug therapy</subject><subject>Urinary Tract Infections - epidemiology</subject><subject>Urinary Tract Infections - microbiology</subject><subject>Young Adult</subject><issn>1937-8688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kNFqHDEMRU2hJGnaX2j92Ifuduzx2JrHNKRJS6AQkufF45EZh1nbtbyB_al8Yx2SIoQu0uEiLmNfRLcVQnfqe7b7x63shNlKvRW6tQAJ79iZGHuzAQ1wyj4QPXad1tB3J-xUgjZqGMYz9nyHFKjaWHleMKZ6zEg8eX5FbsES3BIsd2kNnGqxIRIvSDlFCtOK3KfCDyVEW468nV3lIXp0NaTYFK8L8tVOqdiaGtFcXzYPMTxhoVCP_CZRDtWu_HcizAu_s4TV8h_ocbXtqVbf-EV8VSU8pY_svbcr4ae3ec7uf17dX95sbv9c_7q8uN3kQY8b7YSU4EcDagLfOzBS9yA8GphmZSy4Tkk12QFwlnKA0apRGd93_exGN_v-nH19tc0l_T0g1d0-kMN1tRHTgXZiFAMYGNTQ0M9v6GHa47zLJexbHLv_Eff_AFjLgsE</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Rakotovao-Ravahatra, Zafindrasoa Domoina</creator><creator>Randriatsarafara, Fidiniaina Mamy</creator><creator>Rasoanandrasana, Saïda</creator><creator>Raverohanta, Léa</creator><creator>Rakotovao, Andriamiadana Luc</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Resistant phenotypes of Escherichia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo</title><author>Rakotovao-Ravahatra, Zafindrasoa Domoina ; Randriatsarafara, Fidiniaina Mamy ; Rasoanandrasana, Saïda ; Raverohanta, Léa ; Rakotovao, Andriamiadana Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p569-6c1228f9784b8f3c8726381fe78bd47a8c0424ba58ed22589a4947f303dc9cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Ageism</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli Infections - drug therapy</topic><topic>Escherichia coli Infections - epidemiology</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Infant</topic><topic>Madagascar - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Retrospective Studies</topic><topic>Sex Distribution</topic><topic>Urinary Tract Infections - drug therapy</topic><topic>Urinary Tract Infections - epidemiology</topic><topic>Urinary Tract Infections - microbiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rakotovao-Ravahatra, Zafindrasoa Domoina</creatorcontrib><creatorcontrib>Randriatsarafara, Fidiniaina Mamy</creatorcontrib><creatorcontrib>Rasoanandrasana, Saïda</creatorcontrib><creatorcontrib>Raverohanta, Léa</creatorcontrib><creatorcontrib>Rakotovao, Andriamiadana Luc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Pan African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rakotovao-Ravahatra, Zafindrasoa Domoina</au><au>Randriatsarafara, Fidiniaina Mamy</au><au>Rasoanandrasana, Saïda</au><au>Raverohanta, Léa</au><au>Rakotovao, Andriamiadana Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistant phenotypes of Escherichia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo</atitle><jtitle>The Pan African medical journal</jtitle><addtitle>Pan Afr Med J</addtitle><date>2017</date><risdate>2017</risdate><volume>26</volume><spage>166</spage><epage>166</epage><pages>166-166</pages><eissn>1937-8688</eissn><abstract>Urinary tract infection caused by Escherichia coli frequently occurs in the hospital environment. This study aims to describe resistant phenotypes of Escherichia coli strains to monitor their occurrence.
We conducted a descriptive retrospective study of 102 Escherchia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo from January 2014 to October 2016.
Beta-lactam antibiotic resistance screening identified high-level penicillinases 50% (n=51), Escherichia coli producing extended-spectrum beta-lactamases (ESBLs) 22.5% (n=23), high-level cephalosporinases 14.7% (n=15), penicillinases low level 5.9% (n=6), wild type strains 5.9% (n=6) and a strain ofEscherichia coli emerging strain high-level resistance. Aminoglycosides resistance was identified in 58 (56.9%) wild type phenotype, 29 (28.4%) strains sensitive to amikacin and 15 (14.7%) resistant to all aminoglycosides. Fluoroquinolones resistance was identified in 52 (51%) wild type strains, 9 (8.8%) strains sensitive to ciprofloxacin and 41 (40.2%) resistant to all fluoroquinolones. Women (25, 7%) (p= 0.25, NS), patients more than 60 years (38.7%) (p=0.02), patients hospitalized in the Department of Nephrology (53.8%) (p=0.04), with urinary disorder and kidney disease (29, 7%) (p= 0.2, NS) were the most affected by E-ESBL.
Based on high multidrug resistance in Escherichia coli strains guidelines for the empirical treatment of urinary tract infections need to be revised.</abstract><cop>Uganda</cop><pmid>28674559</pmid><doi>10.11604/pamj.2017.26.166.11828</doi><tpages>1</tpages></addata></record> |
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| subjects | Adolescent Adult Ageism Anti-Bacterial Agents - pharmacology Child Child, Preschool Drug Resistance, Multiple, Bacterial Escherichia coli - drug effects Escherichia coli - isolation & purification Escherichia coli Infections - drug therapy Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Female Hospitalization Hospitals, University Humans Infant Madagascar - epidemiology Male Middle Aged Phenotype Retrospective Studies Sex Distribution Urinary Tract Infections - drug therapy Urinary Tract Infections - epidemiology Urinary Tract Infections - microbiology Young Adult |
| title | Resistant phenotypes of Escherichia coli strains responsible for urinary tract infection in the laboratory of the University Hospital Joseph Raseta Befelatanana, Antananarivo |
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