Early Embryonic Lethality Caused by Targeted Disruption of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Gene

The endoplasmic reticulum (ER) enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which converts HMG-CoA to mevalonate, catalyzes the ratelimiting step in cholesterol biosynthesis. Because this mevalonate pathway also produces several non-sterol isoprenoid compounds, the level of HMG-...

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Veröffentlicht in:	The Journal of biological chemistry 2003-10, Vol.278 (44), p.42936-42941
Hauptverfasser:	Ohashi, Ken, Osuga, Jun-ichi, Tozawa, Ryuichi, Kitamine, Tetsuya, Yagyu, Hiroaki, Sekiya, Motohiro, Tomita, Sachiko, Okazaki, Hiroaki, Tamura, Yoshiaki, Yahagi, Naoya, Iizuka, Yoko, Harada, Kenji, Gotoda, Takanari, Shimano, Hitoshi, Yamada, Nobuhiro, Ishibashi, Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Blotting, Northern Cells, Cultured Cholesterol - metabolism Embryo, Mammalian - pathology Exons Female Fibroblasts - metabolism Genetic Vectors Genotype Heterozygote Homozygote Hydroxymethylglutaryl CoA Reductases - deficiency Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - physiology Lipoproteins - metabolism Liver - metabolism Maternal Exposure mevalonic acid Mevalonic Acid - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Models, Genetic Mutagenesis, Site-Directed Phenotype Pregnancy Pregnancy, Animal Time Factors
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