Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

Highlights • Oral mucositis is one of the side effect in administration of 5-fluorouracil. • Oxidative stress induced by 5-fluorouracil is an initiator of oral mucositis. • Catechins have antioxidant activity. • Catechins could prevent oxidative stress, with up-regulating Nrf2 signaling pathway....

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Veröffentlicht in:	Archives of oral biology 2017-10, Vol.82, p.247-255
Hauptverfasser:	Miyai, Hisataka, Maruyama, Takayuki, Tomofuji, Takaaki, Yoneda, Toshiki, Azuma, Tetsuji, Mizuno, Hirofumi, Sugiura, Yoshio, Kobayashi, Terumasa, Ekuni, Daisuke, Morita, Manabu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Advanced Basic Science Animals Antioxidant capacity Antioxidants - metabolism Catechin - administration & dosage Catechin - pharmacology Chemotherapy Dentistry Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Fluorouracil - toxicity Green tea catechin Male NF-E2-Related Factor 2 - metabolism Ointments - administration & dosage Ointments - pharmacology Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Tea Tongue Tongue - drug effects
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Zusammenfassung:	Highlights • Oral mucositis is one of the side effect in administration of 5-fluorouracil. • Oxidative stress induced by 5-fluorouracil is an initiator of oral mucositis. • Catechins have antioxidant activity. • Catechins could prevent oxidative stress, with up-regulating Nrf2 signaling pathway.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2017.06.025