Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

Functional γ-secretase inhibitors (FGSIs) can block the cleavage of several transmembrane proteins including amyloid precursor protein (APP), and the cell fate regulator Notch-1. FGSIs, by inhibiting APP processing, block the generation of amyloid β (Aβ) peptides and may slow the development of Alzh...

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Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (46), p.46107-46116
Hauptverfasser:	Searfoss, George H., Jordan, William H., Calligaro, David O., Galbreath, Elizabeth J., Schirtzinger, Linda M., Berridge, Brian R., Gao, Hong, Higgins, Marnie A., May, Patrick C., Ryan, Timothy P.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases Base Sequence Binding Sites Cell Differentiation Complement Factor D Digestive System - metabolism Down-Regulation Endopeptidases - chemistry Endopeptidases - metabolism Enzyme Inhibitors - pharmacology Ileum - metabolism Immunohistochemistry Membrane Proteins - metabolism Mice Models, Chemical Molecular Sequence Data Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic Rats Receptors, Notch Reverse Transcriptase Polymerase Chain Reaction Serine Endopeptidases - chemistry Signal Transduction Time Factors Transcription, Genetic Up-Regulation
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