Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology
Rhizoma Alismatis (RA), the dried rhizome of Alisma orientale (Sam.) Juzep, is a common traditional herbal medicine named Ze Xie in Chinese. RA is an important herbal component of a number of well‐known Chinese medicinal preparations. It has been used to treat various ailments, such as dysuria, edem...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2017-08, Vol.1401 (1), p.90-101 |
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| creator | Zhang, Le‐Le Xu, Wen Xu, Yu‐Lian Chen, Xiuping Huang, Mingqing Lu, Jin‐Jian |
| description | Rhizoma Alismatis (RA), the dried rhizome of Alisma orientale (Sam.) Juzep, is a common traditional herbal medicine named Ze Xie in Chinese. RA is an important herbal component of a number of well‐known Chinese medicinal preparations. It has been used to treat various ailments, such as dysuria, edema, nephropathy, hyperlipidemia, and diabetes. A wide range of chemical compounds, mainly triterpenoids, sesquiterpenoids, and diterpenoids, have been isolated from RA; among which the protostane‐type triterpenoids, termed alisols, have attracted the most attention owing to their unique chemical structures and various biological activities. The extract and active compounds of RA possess a wide spectrum of pharmacological effects (e.g., diuretic, antimetabolic disorder, hepatoprotective, immunomodulatory, antiosteoporotic, anti‐inflammatory, antitumor, antibacterial, and antiviral activities). Previous toxicological evaluations indicated that the RA extracts are relatively safe and have no serious side effects within certain dose ranges. This paper reviews the up‐to‐date information on the ethnomedicinal application, phytochemistry, pharmacology, and toxicology of RA. This information will be useful for a better understanding of the therapeutic potential of RA. |
| doi_str_mv | 10.1111/nyas.13381 |
| format | Article |
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Juzep, is a common traditional herbal medicine named Ze Xie in Chinese. RA is an important herbal component of a number of well‐known Chinese medicinal preparations. It has been used to treat various ailments, such as dysuria, edema, nephropathy, hyperlipidemia, and diabetes. A wide range of chemical compounds, mainly triterpenoids, sesquiterpenoids, and diterpenoids, have been isolated from RA; among which the protostane‐type triterpenoids, termed alisols, have attracted the most attention owing to their unique chemical structures and various biological activities. The extract and active compounds of RA possess a wide spectrum of pharmacological effects (e.g., diuretic, antimetabolic disorder, hepatoprotective, immunomodulatory, antiosteoporotic, anti‐inflammatory, antitumor, antibacterial, and antiviral activities). Previous toxicological evaluations indicated that the RA extracts are relatively safe and have no serious side effects within certain dose ranges. This paper reviews the up‐to‐date information on the ethnomedicinal application, phytochemistry, pharmacology, and toxicology of RA. This information will be useful for a better understanding of the therapeutic potential of RA.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/nyas.13381</identifier><identifier>PMID: 28662316</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Alisma ; Animals ; Anticancer properties ; Chemical compounds ; Diabetes mellitus ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - metabolism ; Diterpenes ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - therapeutic use ; Drugs, Chinese Herbal - toxicity ; Edema ; Edema - drug therapy ; Edema - metabolism ; ethnomedicinal application ; Ethnomedicine ; Herbal medicine ; Humans ; Hyperlipidemia ; Immunomodulation ; Inflammation ; Medicine, Traditional - methods ; Nephropathy ; Pharmacology ; Phytochemicals - chemistry ; Phytochemicals - therapeutic use ; Phytochemicals - toxicity ; phytochemistry ; Phytotherapy - methods ; Rhizoma Alismatis ; Rhizome ; Sesquiterpenoids ; Side effects ; Toxicology ; Triterpenoids</subject><ispartof>Annals of the New York Academy of Sciences, 2017-08, Vol.1401 (1), p.90-101</ispartof><rights>2017 New York Academy of Sciences.</rights><rights>2017 The New York Academy of Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-9fd1b7fe30baac4af16d36fa4fb04d817c72c6b491b6d0c8937a6391b076d9473</citedby><cites>FETCH-LOGICAL-c3571-9fd1b7fe30baac4af16d36fa4fb04d817c72c6b491b6d0c8937a6391b076d9473</cites><orcidid>0000-0001-6703-3120</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnyas.13381$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnyas.13381$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28662316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Le‐Le</creatorcontrib><creatorcontrib>Xu, Wen</creatorcontrib><creatorcontrib>Xu, Yu‐Lian</creatorcontrib><creatorcontrib>Chen, Xiuping</creatorcontrib><creatorcontrib>Huang, Mingqing</creatorcontrib><creatorcontrib>Lu, Jin‐Jian</creatorcontrib><title>Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>Rhizoma Alismatis (RA), the dried rhizome of Alisma orientale (Sam.) Juzep, is a common traditional herbal medicine named Ze Xie in Chinese. RA is an important herbal component of a number of well‐known Chinese medicinal preparations. It has been used to treat various ailments, such as dysuria, edema, nephropathy, hyperlipidemia, and diabetes. A wide range of chemical compounds, mainly triterpenoids, sesquiterpenoids, and diterpenoids, have been isolated from RA; among which the protostane‐type triterpenoids, termed alisols, have attracted the most attention owing to their unique chemical structures and various biological activities. The extract and active compounds of RA possess a wide spectrum of pharmacological effects (e.g., diuretic, antimetabolic disorder, hepatoprotective, immunomodulatory, antiosteoporotic, anti‐inflammatory, antitumor, antibacterial, and antiviral activities). Previous toxicological evaluations indicated that the RA extracts are relatively safe and have no serious side effects within certain dose ranges. This paper reviews the up‐to‐date information on the ethnomedicinal application, phytochemistry, pharmacology, and toxicology of RA. This information will be useful for a better understanding of the therapeutic potential of RA.</description><subject>Alisma</subject><subject>Animals</subject><subject>Anticancer properties</subject><subject>Chemical compounds</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diterpenes</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Drugs, Chinese Herbal - toxicity</subject><subject>Edema</subject><subject>Edema - drug therapy</subject><subject>Edema - metabolism</subject><subject>ethnomedicinal application</subject><subject>Ethnomedicine</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Medicine, Traditional - methods</subject><subject>Nephropathy</subject><subject>Pharmacology</subject><subject>Phytochemicals - chemistry</subject><subject>Phytochemicals - therapeutic use</subject><subject>Phytochemicals - toxicity</subject><subject>phytochemistry</subject><subject>Phytotherapy - methods</subject><subject>Rhizoma Alismatis</subject><subject>Rhizome</subject><subject>Sesquiterpenoids</subject><subject>Side effects</subject><subject>Toxicology</subject><subject>Triterpenoids</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EapfSCz8AWeKCECme2Gsnva0qoEgVSFAOnKKJ4xBXSZzaDm049afjJS0HDsxl9KRvnmbmEfIc2AmkejsuGE6A8wIekQ0oUWZS8vwx2TCmVFaUOT8kT0O4YgzyQqgDcpgXUuYc5IbcXXbG42TmaDWdXDRjtNhT19Ivnf3lBqS73oYBow2nFKk3P625oW6kJnajG0xjtR3TAE5Tb3XC3PiGTt0Sne7MYEP0y16jH1C73v1ICseGRndrV_2MPGmxD-b4vh-Rb-_fXZ6dZxefP3w8211kmm8VZGXbQK1aw1mNqAW2IBsuWxRtzURTgNIq17IWJdSyYboouULJk2JKNqVQ_Ii8Wn0n765nE2KVttOm73E0bg4VlLDlWwYgEvryH_TKzT5duae44lCIfJuo1yulvQvBm7aavB3QLxWwap9Ltc-l-pNLgl_cW851etpf9CGIBMAK3NjeLP-xqj59331dTX8D5v2asQ</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Zhang, Le‐Le</creator><creator>Xu, Wen</creator><creator>Xu, Yu‐Lian</creator><creator>Chen, Xiuping</creator><creator>Huang, Mingqing</creator><creator>Lu, Jin‐Jian</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6703-3120</orcidid></search><sort><creationdate>201708</creationdate><title>Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology</title><author>Zhang, Le‐Le ; Xu, Wen ; Xu, Yu‐Lian ; Chen, Xiuping ; Huang, Mingqing ; Lu, Jin‐Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-9fd1b7fe30baac4af16d36fa4fb04d817c72c6b491b6d0c8937a6391b076d9473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alisma</topic><topic>Animals</topic><topic>Anticancer properties</topic><topic>Chemical compounds</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diterpenes</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Drugs, Chinese Herbal - toxicity</topic><topic>Edema</topic><topic>Edema - drug therapy</topic><topic>Edema - metabolism</topic><topic>ethnomedicinal application</topic><topic>Ethnomedicine</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>Immunomodulation</topic><topic>Inflammation</topic><topic>Medicine, Traditional - methods</topic><topic>Nephropathy</topic><topic>Pharmacology</topic><topic>Phytochemicals - chemistry</topic><topic>Phytochemicals - therapeutic use</topic><topic>Phytochemicals - toxicity</topic><topic>phytochemistry</topic><topic>Phytotherapy - methods</topic><topic>Rhizoma Alismatis</topic><topic>Rhizome</topic><topic>Sesquiterpenoids</topic><topic>Side effects</topic><topic>Toxicology</topic><topic>Triterpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Le‐Le</creatorcontrib><creatorcontrib>Xu, Wen</creatorcontrib><creatorcontrib>Xu, Yu‐Lian</creatorcontrib><creatorcontrib>Chen, Xiuping</creatorcontrib><creatorcontrib>Huang, Mingqing</creatorcontrib><creatorcontrib>Lu, Jin‐Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Le‐Le</au><au>Xu, Wen</au><au>Xu, Yu‐Lian</au><au>Chen, Xiuping</au><au>Huang, Mingqing</au><au>Lu, Jin‐Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2017-08</date><risdate>2017</risdate><volume>1401</volume><issue>1</issue><spage>90</spage><epage>101</epage><pages>90-101</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>Rhizoma Alismatis (RA), the dried rhizome of Alisma orientale (Sam.) Juzep, is a common traditional herbal medicine named Ze Xie in Chinese. RA is an important herbal component of a number of well‐known Chinese medicinal preparations. It has been used to treat various ailments, such as dysuria, edema, nephropathy, hyperlipidemia, and diabetes. A wide range of chemical compounds, mainly triterpenoids, sesquiterpenoids, and diterpenoids, have been isolated from RA; among which the protostane‐type triterpenoids, termed alisols, have attracted the most attention owing to their unique chemical structures and various biological activities. The extract and active compounds of RA possess a wide spectrum of pharmacological effects (e.g., diuretic, antimetabolic disorder, hepatoprotective, immunomodulatory, antiosteoporotic, anti‐inflammatory, antitumor, antibacterial, and antiviral activities). Previous toxicological evaluations indicated that the RA extracts are relatively safe and have no serious side effects within certain dose ranges. This paper reviews the up‐to‐date information on the ethnomedicinal application, phytochemistry, pharmacology, and toxicology of RA. This information will be useful for a better understanding of the therapeutic potential of RA.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28662316</pmid><doi>10.1111/nyas.13381</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6703-3120</orcidid></addata></record> |
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| subjects | Alisma Animals Anticancer properties Chemical compounds Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diterpenes Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - therapeutic use Drugs, Chinese Herbal - toxicity Edema Edema - drug therapy Edema - metabolism ethnomedicinal application Ethnomedicine Herbal medicine Humans Hyperlipidemia Immunomodulation Inflammation Medicine, Traditional - methods Nephropathy Pharmacology Phytochemicals - chemistry Phytochemicals - therapeutic use Phytochemicals - toxicity phytochemistry Phytotherapy - methods Rhizoma Alismatis Rhizome Sesquiterpenoids Side effects Toxicology Triterpenoids |
| title | Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology |
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