Activation of murine macrophages by G1-4A, a polysaccharide from Tinospora cordifolia, in TLR4/MyD88 dependent manner

Macrophages are centrally placed in the innate immune system and their activation is crucial to the generation of appropriate immune response in the event of any pathogenic invasion, tumorigenesis or other human diseases. Many plant derived polysaccharides are known to activate macrophages. In the p...

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Veröffentlicht in:	International immunopharmacology 2017-09, Vol.50, p.168-177
Hauptverfasser:	Gupta, Pramod Kumar, Rajan, M.G.R., Kulkarni, Savita
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Antibodies Antibodies, Blocking - metabolism Blocking antibodies Cell activation Classical pathway Cytokines Cytokines - metabolism Female Herbal medicine Immune response Immune system Immunity, Innate Immunomodulator Inflammation Mediators - metabolism Innate immunity Interferon Interleukin 10 Interleukin 12 Interleukin 6 JNK protein Macrophage Macrophage Activation Macrophages Macrophages - immunology Major histocompatibility complex MAP Kinase Signaling System Mice Mice, Inbred BALB C MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Nitric oxide Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Peritoneum Polysaccharides Polysaccharides - immunology RAW 264.7 Cells RNA, Small Interfering - genetics Saccharides Signal Transduction siRNA Tinospora - immunology Tinospora cordifolia TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor necrosis factor-α Tumorigenesis γ-Interferon
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