MicroRNA-124 controls human vascular smooth muscle cell phenotypic switch via Sp1

Phenotypic switch of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of atherosclerosis and aortic dissection. However, the mechanisms of phenotypic modulation are still unclear. MicroRNAs have emerged as important regulators of VSMC function. We recently found that...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2017-09, Vol.313 (3), p.H641-H649
Hauptverfasser:	Tang, Yangfeng, Yu, Shangyi, Liu, Yang, Zhang, Jiajun, Han, Lin, Xu, Zhiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adult Aorta Aortic Aneurysm - genetics Aortic Aneurysm - metabolism Aortic Aneurysm - pathology Aortic Dissection - genetics Aortic Dissection - metabolism Aortic Dissection - pathology Atherosclerosis Binding Sites Cardiovascular system Case-Control Studies Cell Differentiation Cell Proliferation Cells Cells, Cultured Down-Regulation Gene expression Genotype & phenotype Growth factors Humans MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Modulation Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscles Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Pathogenesis Phenotype Platelet-derived growth factor Regulators Ribonucleic acid RNA Signal Transduction Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Time Factors Transfection
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