Cannabinoids prevent the differential long‐term effects of exposure to severe stress on hippocampal‐ and amygdala‐dependent memory and plasticity

Exposure to excessive or uncontrolled stress is a major factor associated with various diseases including posttraumatic stress disorder (PTSD). The consequences of exposure to trauma are affected not only by aspects of the event itself, but also by the frequency and severity of trauma reminders. It...

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Veröffentlicht in:	Hippocampus 2017-10, Vol.27 (10), p.1093-1109
Hauptverfasser:	Shoshan, Noa, Segev, Amir, Abush, Hila, Mizrachi Zer‐Aviv, Tomer, Akirav, Irit
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Amygdala Amygdala - drug effects Amygdala - pathology Amygdala - physiopathology Animal behavior Animals Avoidance Learning - drug effects Avoidance Learning - physiology Benzamides - pharmacology Benzoxazines - pharmacology Bromine - pharmacology Cannabinoid CB1 receptors Cannabinoid Receptor Modulators - pharmacology Cannabinoids - pharmacology Carbamates - pharmacology CB1 Disease Models, Animal Drug Combinations Electroshock Enzyme Inhibitors - pharmacology extinction Extinction behavior Fatty-acid amide hydrolase Fear - drug effects Fear - physiology Glutamates - pharmacology Hippocampal plasticity Hippocampus Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Hydrolase Long-term effects Long-term potentiation LTP Magnesium - pharmacology Male Memory - drug effects Memory - physiology Morpholines - pharmacology Naphthalenes - pharmacology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Piperidines - pharmacology Post traumatic stress disorder posttraumatic stress disorder (PTSD) Pyrazoles - pharmacology Rats, Sprague-Dawley receptors Receptors, Cannabinoid - metabolism Rodents Shock Short term memory Stress Disorders, Post-Traumatic - drug therapy Stress Disorders, Post-Traumatic - pathology Stress Disorders, Post-Traumatic - physiopathology Stress Disorders, Post-Traumatic - psychology Taste aversion Trauma URB597
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