In vitro and in vivo inhibition of proangiogenic retinal phenotype by an antisense oligonucleotide downregulating uPAR expression

Neoangiogenesis is the main pathogenic event involved in a variety of retinal diseases. It has been recently demonstrated that inhibiting the urokinase-type plasminogen activator receptor (uPAR) results in reduced angiogenesis in a mouse model of oxygen-induced retinopathy (OIR), establishing uPAR a...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-08, Vol.490 (3), p.977-983
Hauptverfasser:	Lulli, Matteo, Cammalleri, Maurizio, Granucci, Irene, Witort, Ewa, Bono, Silvia, Di Gesualdo, Federico, Lupia, Antonella, Loffredo, Rosa, Casini, Giovanni, Dal Monte, Massimo, Capaccioli, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - genetics Angiogenesis Inhibitors - therapeutic use Animals Cell Line Cell Movement - drug effects Disease Models, Animal Genetic Therapy Human retinal endothelial cells Humans Mice Oligodeoxyribonucleotides, Antisense - genetics Oligodeoxyribonucleotides, Antisense - therapeutic use Receptors, Urokinase Plasminogen Activator - analysis Receptors, Urokinase Plasminogen Activator - genetics Receptors, Urokinase Plasminogen Activator - metabolism Retina - cytology Retina - metabolism Retina - pathology Retinal diseases Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinal Neovascularization - therapy RNA, Messenger - genetics Vascular Endothelial Growth Factor A - metabolism VEGF
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