Association of decreased mean platelet volume with renal cell carcinoma
Background Renal cell carcinoma (RCC) is the third most common genitourinary cancer. Activated platelets play a pivotal role in cancer development and progression. Altered mean platelet volume (MPV) has been reported in several malignancies. The aim of the present study was to investigate the associ...
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| Veröffentlicht in: | International journal of clinical oncology 2017-12, Vol.22 (6), p.1076-1080 |
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| creator | Yun, Zhi-yuan Zhang, Xin Liu, Zhi-ping Liu, Tiemin Wang, Rui-tao Chen, Hui |
| description | Background
Renal cell carcinoma (RCC) is the third most common genitourinary cancer. Activated platelets play a pivotal role in cancer development and progression. Altered mean platelet volume (MPV) has been reported in several malignancies. The aim of the present study was to investigate the association of MPV with RCC.
Study design
The study consisted of 145 patients with RCC, 110 patients with benign renal tumor and 132 healthy control subjects between January 2015 and December 2015. All participants’ clinical and laboratory characteristics at initial diagnosis were collected. The odds ratios (ORs) for RCC were calculated using multivariate logistic regression analysis after adjusting for confounding variables across MPV quartiles.
Results
The patients with RCC had decreased pre-operative MPV compared to the patients with benign renal tumor and healthy control subjects. Furthermore, pre-operative MPV was reduced in benign renal tumor compared with healthy control subjects. Surgical tumor resection resulted in a significant increase in MPV levels (8.7 fL vs. 9.0 fL;
p
= 0.011). After adjusting for other risk factors, the ORs (95% CIs) for RCC in each MPV quartile were 25.725 (7.556–87.585), 7.447 (2.701–20.537), 0.703 (0.245–2.019), and 1.000, respectively.
Conclusions
RCC patients have remarkably reduced MPV compared to patients with benign renal tumor and healthy control subjects. Moreover, decreased MPV was independently associated with RCC. Our results suggest that detection of MPV may be useful to assess the risk of RCC. |
| doi_str_mv | 10.1007/s10147-017-1158-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1915342978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1961501088</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-83b8fb2f82b80f7c59585bd8b8b04ee19cfedb9303f6c283c976d81886cfb7ca3</originalsourceid><addsrcrecordid>eNp1kMFq3DAQhkVJ6G43eYBcgiGXXNxqJFuSj8vSpoFAL8lZSPKo9WJbG8lOydtXZpMQCrloBPPNP8NHyAXQr0Cp_JaAQiVLCrIEqFXJPpE1VFyWUkp2kv-8grIRrF6RLyntaQZFzT6TFVNCVJzCmtxsUwquM1MXxiL4okUX0SRsiwHNWBx6M2GPU_EU-nnA4m83_SkijqYvHPb5MdF1YxjMGTn1pk94_lI35OHH9_vdz_Lu183tbntXOt6IqVTcKm-ZV8wq6qWrm1rVtlVWWVohQuM8trbhlHvhmOKukaJVoJRw3kpn-IZcH3MPMTzOmCY9dGk5xYwY5qShgZpXrJEqo1f_ofswx3z6QgmoKVC1UHCkXAwpRfT6ELvBxGcNVC-W9dGyzvL0YlmzPHP5kjzbAdu3iVetGWBHIOXW-Bvju9Ufpv4DteyHAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1961501088</pqid></control><display><type>article</type><title>Association of decreased mean platelet volume with renal cell carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Yun, Zhi-yuan ; Zhang, Xin ; Liu, Zhi-ping ; Liu, Tiemin ; Wang, Rui-tao ; Chen, Hui</creator><creatorcontrib>Yun, Zhi-yuan ; Zhang, Xin ; Liu, Zhi-ping ; Liu, Tiemin ; Wang, Rui-tao ; Chen, Hui</creatorcontrib><description>Background
Renal cell carcinoma (RCC) is the third most common genitourinary cancer. Activated platelets play a pivotal role in cancer development and progression. Altered mean platelet volume (MPV) has been reported in several malignancies. The aim of the present study was to investigate the association of MPV with RCC.
Study design
The study consisted of 145 patients with RCC, 110 patients with benign renal tumor and 132 healthy control subjects between January 2015 and December 2015. All participants’ clinical and laboratory characteristics at initial diagnosis were collected. The odds ratios (ORs) for RCC were calculated using multivariate logistic regression analysis after adjusting for confounding variables across MPV quartiles.
Results
The patients with RCC had decreased pre-operative MPV compared to the patients with benign renal tumor and healthy control subjects. Furthermore, pre-operative MPV was reduced in benign renal tumor compared with healthy control subjects. Surgical tumor resection resulted in a significant increase in MPV levels (8.7 fL vs. 9.0 fL;
p
= 0.011). After adjusting for other risk factors, the ORs (95% CIs) for RCC in each MPV quartile were 25.725 (7.556–87.585), 7.447 (2.701–20.537), 0.703 (0.245–2.019), and 1.000, respectively.
Conclusions
RCC patients have remarkably reduced MPV compared to patients with benign renal tumor and healthy control subjects. Moreover, decreased MPV was independently associated with RCC. Our results suggest that detection of MPV may be useful to assess the risk of RCC.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-017-1158-2</identifier><identifier>PMID: 28664301</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Benign ; Cancer Research ; Carcinoma, Renal Cell - blood ; Carcinoma, Renal Cell - pathology ; Case-Control Studies ; Cells ; Female ; Health risk assessment ; Humans ; Kidney cancer ; Kidney Neoplasms - blood ; Kidney Neoplasms - pathology ; Male ; Mean Platelet Volume ; Medicine ; Medicine & Public Health ; Middle Aged ; Odds Ratio ; Oncology ; Original Article ; Platelets ; Renal cell carcinoma ; Risk Factors ; Surgical Oncology</subject><ispartof>International journal of clinical oncology, 2017-12, Vol.22 (6), p.1076-1080</ispartof><rights>Japan Society of Clinical Oncology 2017</rights><rights>International Journal of Clinical Oncology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-83b8fb2f82b80f7c59585bd8b8b04ee19cfedb9303f6c283c976d81886cfb7ca3</citedby><cites>FETCH-LOGICAL-c396t-83b8fb2f82b80f7c59585bd8b8b04ee19cfedb9303f6c283c976d81886cfb7ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10147-017-1158-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10147-017-1158-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28664301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yun, Zhi-yuan</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Liu, Zhi-ping</creatorcontrib><creatorcontrib>Liu, Tiemin</creatorcontrib><creatorcontrib>Wang, Rui-tao</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><title>Association of decreased mean platelet volume with renal cell carcinoma</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><addtitle>Int J Clin Oncol</addtitle><description>Background
Renal cell carcinoma (RCC) is the third most common genitourinary cancer. Activated platelets play a pivotal role in cancer development and progression. Altered mean platelet volume (MPV) has been reported in several malignancies. The aim of the present study was to investigate the association of MPV with RCC.
Study design
The study consisted of 145 patients with RCC, 110 patients with benign renal tumor and 132 healthy control subjects between January 2015 and December 2015. All participants’ clinical and laboratory characteristics at initial diagnosis were collected. The odds ratios (ORs) for RCC were calculated using multivariate logistic regression analysis after adjusting for confounding variables across MPV quartiles.
Results
The patients with RCC had decreased pre-operative MPV compared to the patients with benign renal tumor and healthy control subjects. Furthermore, pre-operative MPV was reduced in benign renal tumor compared with healthy control subjects. Surgical tumor resection resulted in a significant increase in MPV levels (8.7 fL vs. 9.0 fL;
p
= 0.011). After adjusting for other risk factors, the ORs (95% CIs) for RCC in each MPV quartile were 25.725 (7.556–87.585), 7.447 (2.701–20.537), 0.703 (0.245–2.019), and 1.000, respectively.
Conclusions
RCC patients have remarkably reduced MPV compared to patients with benign renal tumor and healthy control subjects. Moreover, decreased MPV was independently associated with RCC. Our results suggest that detection of MPV may be useful to assess the risk of RCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Benign</subject><subject>Cancer Research</subject><subject>Carcinoma, Renal Cell - blood</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Case-Control Studies</subject><subject>Cells</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Kidney cancer</subject><subject>Kidney Neoplasms - blood</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>Mean Platelet Volume</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Platelets</subject><subject>Renal cell carcinoma</subject><subject>Risk Factors</subject><subject>Surgical Oncology</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kMFq3DAQhkVJ6G43eYBcgiGXXNxqJFuSj8vSpoFAL8lZSPKo9WJbG8lOydtXZpMQCrloBPPNP8NHyAXQr0Cp_JaAQiVLCrIEqFXJPpE1VFyWUkp2kv-8grIRrF6RLyntaQZFzT6TFVNCVJzCmtxsUwquM1MXxiL4okUX0SRsiwHNWBx6M2GPU_EU-nnA4m83_SkijqYvHPb5MdF1YxjMGTn1pk94_lI35OHH9_vdz_Lu183tbntXOt6IqVTcKm-ZV8wq6qWrm1rVtlVWWVohQuM8trbhlHvhmOKukaJVoJRw3kpn-IZcH3MPMTzOmCY9dGk5xYwY5qShgZpXrJEqo1f_ofswx3z6QgmoKVC1UHCkXAwpRfT6ELvBxGcNVC-W9dGyzvL0YlmzPHP5kjzbAdu3iVetGWBHIOXW-Bvju9Ufpv4DteyHAA</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Yun, Zhi-yuan</creator><creator>Zhang, Xin</creator><creator>Liu, Zhi-ping</creator><creator>Liu, Tiemin</creator><creator>Wang, Rui-tao</creator><creator>Chen, Hui</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>Association of decreased mean platelet volume with renal cell carcinoma</title><author>Yun, Zhi-yuan ; Zhang, Xin ; Liu, Zhi-ping ; Liu, Tiemin ; Wang, Rui-tao ; Chen, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-83b8fb2f82b80f7c59585bd8b8b04ee19cfedb9303f6c283c976d81886cfb7ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Benign</topic><topic>Cancer Research</topic><topic>Carcinoma, Renal Cell - blood</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Case-Control Studies</topic><topic>Cells</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Kidney cancer</topic><topic>Kidney Neoplasms - blood</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>Mean Platelet Volume</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Platelets</topic><topic>Renal cell carcinoma</topic><topic>Risk Factors</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yun, Zhi-yuan</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Liu, Zhi-ping</creatorcontrib><creatorcontrib>Liu, Tiemin</creatorcontrib><creatorcontrib>Wang, Rui-tao</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yun, Zhi-yuan</au><au>Zhang, Xin</au><au>Liu, Zhi-ping</au><au>Liu, Tiemin</au><au>Wang, Rui-tao</au><au>Chen, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of decreased mean platelet volume with renal cell carcinoma</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><addtitle>Int J Clin Oncol</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>22</volume><issue>6</issue><spage>1076</spage><epage>1080</epage><pages>1076-1080</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background
Renal cell carcinoma (RCC) is the third most common genitourinary cancer. Activated platelets play a pivotal role in cancer development and progression. Altered mean platelet volume (MPV) has been reported in several malignancies. The aim of the present study was to investigate the association of MPV with RCC.
Study design
The study consisted of 145 patients with RCC, 110 patients with benign renal tumor and 132 healthy control subjects between January 2015 and December 2015. All participants’ clinical and laboratory characteristics at initial diagnosis were collected. The odds ratios (ORs) for RCC were calculated using multivariate logistic regression analysis after adjusting for confounding variables across MPV quartiles.
Results
The patients with RCC had decreased pre-operative MPV compared to the patients with benign renal tumor and healthy control subjects. Furthermore, pre-operative MPV was reduced in benign renal tumor compared with healthy control subjects. Surgical tumor resection resulted in a significant increase in MPV levels (8.7 fL vs. 9.0 fL;
p
= 0.011). After adjusting for other risk factors, the ORs (95% CIs) for RCC in each MPV quartile were 25.725 (7.556–87.585), 7.447 (2.701–20.537), 0.703 (0.245–2.019), and 1.000, respectively.
Conclusions
RCC patients have remarkably reduced MPV compared to patients with benign renal tumor and healthy control subjects. Moreover, decreased MPV was independently associated with RCC. Our results suggest that detection of MPV may be useful to assess the risk of RCC.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>28664301</pmid><doi>10.1007/s10147-017-1158-2</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Benign Cancer Research Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - pathology Case-Control Studies Cells Female Health risk assessment Humans Kidney cancer Kidney Neoplasms - blood Kidney Neoplasms - pathology Male Mean Platelet Volume Medicine Medicine & Public Health Middle Aged Odds Ratio Oncology Original Article Platelets Renal cell carcinoma Risk Factors Surgical Oncology |
| title | Association of decreased mean platelet volume with renal cell carcinoma |
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