Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia
BACKGROUND AND PURPOSE—Preclinical studies suggest that exercise can enhance cognition after cerebral ischemia but often use long training regiments and test cognition during or acutely after training. The cognitive changes may result from enhanced physical fitness and may only provide acute benefit...
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| Veröffentlicht in: | Stroke (1970) 2017-08, Vol.48 (8), p.2306-2309 |
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| container_title | Stroke (1970) |
| container_volume | 48 |
| creator | Stradecki-Cohan, Holly M Youbi, Mehdi Cohan, Charles H Saul, Isa Garvin, Alexandra A Perez, Edwin Dave, Kunjan R Wright, Clinton B Sacco, Ralph L Perez-Pinzon, Miguel A |
| description | BACKGROUND AND PURPOSE—Preclinical studies suggest that exercise can enhance cognition after cerebral ischemia but often use long training regiments and test cognition during or acutely after training. The cognitive changes may result from enhanced physical fitness and may only provide acute benefit. We sought to determine whether a short period of exercise after cerebral ischemia could improve cognitive outcomes when measured days after completion of exercise training in 2 cerebral ischemia models.
METHODS—Focal or global cerebral ischemia was induced in Sprague-Dawley rats. Rats recovered (3–4 days) then were subject to no exercise (0 m/min), mild (6 m/min), moderate (10 m/min), or heavy (15–18 m/min) treadmill exercise (5–6 days). Cognition was tested 8 to 10 days after the last exercise session with hippocampal-dependent contextual fear conditioning.
RESULTS—A short training period of moderate exercise enhanced cognitive function for a week after exercise completion in both models of cerebral ischemia.
CONCLUSIONS—Utilization of this exercise paradigm can further the elucidation of exercise-mediated factors involved in cognitive recovery independent of changes in physical fitness. |
| doi_str_mv | 10.1161/STROKEAHA.117.017296 |
| format | Article |
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METHODS—Focal or global cerebral ischemia was induced in Sprague-Dawley rats. Rats recovered (3–4 days) then were subject to no exercise (0 m/min), mild (6 m/min), moderate (10 m/min), or heavy (15–18 m/min) treadmill exercise (5–6 days). Cognition was tested 8 to 10 days after the last exercise session with hippocampal-dependent contextual fear conditioning.
RESULTS—A short training period of moderate exercise enhanced cognitive function for a week after exercise completion in both models of cerebral ischemia.
CONCLUSIONS—Utilization of this exercise paradigm can further the elucidation of exercise-mediated factors involved in cognitive recovery independent of changes in physical fitness.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.117.017296</identifier><identifier>PMID: 28663509</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Cognition - physiology ; Disease Models, Animal ; Ischemic Attack, Transient - physiopathology ; Ischemic Attack, Transient - psychology ; Ischemic Attack, Transient - therapy ; Male ; Physical Conditioning, Animal - methods ; Physical Conditioning, Animal - physiology ; Physical Conditioning, Animal - psychology ; Random Allocation ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Stroke (1970), 2017-08, Vol.48 (8), p.2306-2309</ispartof><rights>2017 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4476-37d350a2da355cf4eed441bd474da5aa58f3b43698e35b1f2cd786731d24fc553</citedby><cites>FETCH-LOGICAL-c4476-37d350a2da355cf4eed441bd474da5aa58f3b43698e35b1f2cd786731d24fc553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28663509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stradecki-Cohan, Holly M</creatorcontrib><creatorcontrib>Youbi, Mehdi</creatorcontrib><creatorcontrib>Cohan, Charles H</creatorcontrib><creatorcontrib>Saul, Isa</creatorcontrib><creatorcontrib>Garvin, Alexandra A</creatorcontrib><creatorcontrib>Perez, Edwin</creatorcontrib><creatorcontrib>Dave, Kunjan R</creatorcontrib><creatorcontrib>Wright, Clinton B</creatorcontrib><creatorcontrib>Sacco, Ralph L</creatorcontrib><creatorcontrib>Perez-Pinzon, Miguel A</creatorcontrib><title>Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—Preclinical studies suggest that exercise can enhance cognition after cerebral ischemia but often use long training regiments and test cognition during or acutely after training. The cognitive changes may result from enhanced physical fitness and may only provide acute benefit. We sought to determine whether a short period of exercise after cerebral ischemia could improve cognitive outcomes when measured days after completion of exercise training in 2 cerebral ischemia models.
METHODS—Focal or global cerebral ischemia was induced in Sprague-Dawley rats. Rats recovered (3–4 days) then were subject to no exercise (0 m/min), mild (6 m/min), moderate (10 m/min), or heavy (15–18 m/min) treadmill exercise (5–6 days). Cognition was tested 8 to 10 days after the last exercise session with hippocampal-dependent contextual fear conditioning.
RESULTS—A short training period of moderate exercise enhanced cognitive function for a week after exercise completion in both models of cerebral ischemia.
CONCLUSIONS—Utilization of this exercise paradigm can further the elucidation of exercise-mediated factors involved in cognitive recovery independent of changes in physical fitness.</description><subject>Animals</subject><subject>Cognition - physiology</subject><subject>Disease Models, Animal</subject><subject>Ischemic Attack, Transient - physiopathology</subject><subject>Ischemic Attack, Transient - psychology</subject><subject>Ischemic Attack, Transient - therapy</subject><subject>Male</subject><subject>Physical Conditioning, Animal - methods</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical Conditioning, Animal - psychology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1PGzEUtKpWJaT9BxXykcuCv717jKLQRIBStUHitvLab4nb_QB7N5R_X6MFjvTw_DTWzHg0RugbJWeUKnr-a_dze7larBcJ6jNCNSvUBzSjkolMKJZ_RDNCeJExURRH6DjG34QQxnP5GR2xXCkuSTFDtz_2T9Fb0-DVXwjWR8Cb9j70B4h42d91fvAHwNtxsH2brnyHGb7uHTQR9zXeBdNFD92AlxCgCslmE-0eWm--oE-1aSJ8fdlzdHOx2i3X2dX2-2a5uMqsEFplXLsUxDBnuJS2FgBOCFo5oYUz0hiZ17wSXBU5cFnRmlmnc6U5dUzUVko-R6eTbwr9MEIcytZHC01jOujHWNKCSi7Y8zlHYqLa0McYoC7vg29NeCopKZ87Ld86TVCXU6dJdvLywli14N5EryUmQj4RHvtmgBD_NOMjhHIPphn2__MW70jThxGtNMlYopM8oSyNUPwfMNCUeg</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Stradecki-Cohan, Holly M</creator><creator>Youbi, Mehdi</creator><creator>Cohan, Charles H</creator><creator>Saul, Isa</creator><creator>Garvin, Alexandra A</creator><creator>Perez, Edwin</creator><creator>Dave, Kunjan R</creator><creator>Wright, Clinton B</creator><creator>Sacco, Ralph L</creator><creator>Perez-Pinzon, Miguel A</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia</title><author>Stradecki-Cohan, Holly M ; Youbi, Mehdi ; Cohan, Charles H ; Saul, Isa ; Garvin, Alexandra A ; Perez, Edwin ; Dave, Kunjan R ; Wright, Clinton B ; Sacco, Ralph L ; Perez-Pinzon, Miguel A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4476-37d350a2da355cf4eed441bd474da5aa58f3b43698e35b1f2cd786731d24fc553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Cognition - physiology</topic><topic>Disease Models, Animal</topic><topic>Ischemic Attack, Transient - physiopathology</topic><topic>Ischemic Attack, Transient - psychology</topic><topic>Ischemic Attack, Transient - therapy</topic><topic>Male</topic><topic>Physical Conditioning, Animal - methods</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical Conditioning, Animal - psychology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stradecki-Cohan, Holly M</creatorcontrib><creatorcontrib>Youbi, Mehdi</creatorcontrib><creatorcontrib>Cohan, Charles H</creatorcontrib><creatorcontrib>Saul, Isa</creatorcontrib><creatorcontrib>Garvin, Alexandra A</creatorcontrib><creatorcontrib>Perez, Edwin</creatorcontrib><creatorcontrib>Dave, Kunjan R</creatorcontrib><creatorcontrib>Wright, Clinton B</creatorcontrib><creatorcontrib>Sacco, Ralph L</creatorcontrib><creatorcontrib>Perez-Pinzon, Miguel A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stradecki-Cohan, Holly M</au><au>Youbi, Mehdi</au><au>Cohan, Charles H</au><au>Saul, Isa</au><au>Garvin, Alexandra A</au><au>Perez, Edwin</au><au>Dave, Kunjan R</au><au>Wright, Clinton B</au><au>Sacco, Ralph L</au><au>Perez-Pinzon, Miguel A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2017-08</date><risdate>2017</risdate><volume>48</volume><issue>8</issue><spage>2306</spage><epage>2309</epage><pages>2306-2309</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>BACKGROUND AND PURPOSE—Preclinical studies suggest that exercise can enhance cognition after cerebral ischemia but often use long training regiments and test cognition during or acutely after training. The cognitive changes may result from enhanced physical fitness and may only provide acute benefit. We sought to determine whether a short period of exercise after cerebral ischemia could improve cognitive outcomes when measured days after completion of exercise training in 2 cerebral ischemia models.
METHODS—Focal or global cerebral ischemia was induced in Sprague-Dawley rats. Rats recovered (3–4 days) then were subject to no exercise (0 m/min), mild (6 m/min), moderate (10 m/min), or heavy (15–18 m/min) treadmill exercise (5–6 days). Cognition was tested 8 to 10 days after the last exercise session with hippocampal-dependent contextual fear conditioning.
RESULTS—A short training period of moderate exercise enhanced cognitive function for a week after exercise completion in both models of cerebral ischemia.
CONCLUSIONS—Utilization of this exercise paradigm can further the elucidation of exercise-mediated factors involved in cognitive recovery independent of changes in physical fitness.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>28663509</pmid><doi>10.1161/STROKEAHA.117.017296</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cognition - physiology Disease Models, Animal Ischemic Attack, Transient - physiopathology Ischemic Attack, Transient - psychology Ischemic Attack, Transient - therapy Male Physical Conditioning, Animal - methods Physical Conditioning, Animal - physiology Physical Conditioning, Animal - psychology Random Allocation Rats Rats, Sprague-Dawley |
| title | Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia |
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