Bezafibrate Induces a Mitochondrial Derangement in Human Cell Lines: A PPAR-Independent Mechanism for a Peroxisome Proliferator

Bezafibrate is a hypolipidemic drug that belongs to the group of peroxisome proliferators because it binds to peroxisome proliferator-activated receptors type α (PPARs). Peroxisome proliferators produce a myriad of extraperoxisomal effects, which are not necessarily dependent on their interaction wi...

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Veröffentlicht in:	Chemical research in toxicology 2003-11, Vol.16 (11), p.1440-1447
Hauptverfasser:	Scatena, R, Bottoni, P, Vincenzoni, F, Messana, I, Martorana, G. E, Nocca, G, De Sole, P, Maggiano, N, Castagnola, M, Giardina, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Acetates - metabolism Alanine - chemistry Alanine - metabolism Animals bezafibrate Bezafibrate - adverse effects Bezafibrate - metabolism Bezafibrate - pharmacology Dose-Response Relationship, Drug Humans Hypolipidemic Agents - adverse effects Hypolipidemic Agents - metabolism Hypolipidemic Agents - pharmacology Italy Lactic Acid - chemistry Lactic Acid - metabolism Magnetic Resonance Spectroscopy Microscopy, Electron Mitochondria - drug effects Mitochondria - physiology Mitochondrial Diseases - chemically induced peroxisome proliferator-activated receptor- alpha Peroxisome Proliferators - adverse effects Peroxisome Proliferators - metabolism Peroxisome Proliferators - pharmacology Rats Time Factors Tumor Cells, Cultured
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