Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton

An efficient total synthesis of TAN1251C was accomplished by employing a Ugi four-component accumulation reaction and a Dieckmann condensation to construct the spiro-fused cyclohexanone and γ-lactam ring. Diastereoselective reduction by side-chain-controlled hydrogenation of enamide 15 or Zn reducti...

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Veröffentlicht in:	Organic letters 2017-07, Vol.19 (14), p.3839-3842
Hauptverfasser:	Nagasaka, Yosuke, Shintaku, Sayaka, Matsumura, Kosuke, Masuda, Akitaka, Asakawa, Tomohiro, Inai, Makoto, Egi, Masahiro, Hamashima, Yoshitaka, Ishikawa, Yoshinobu, Kan, Toshiyuki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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