Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases
Cryoglobulinemia can induce systemic vasculitis affecting various organs such as skin, peripheral nerves, and kidney. The disease can induce chronic organ failure and even be life‐threatening. Cryofiltration has been applied for the treatment of cryoglobulinemic vasculitis. We have experienced four...
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| Veröffentlicht in: | Therapeutic apheresis and dialysis 2017-06, Vol.21 (3), p.238-242 |
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| creator | Taniyama, Yoshihiro Nakatani, Yoshihisa Matsuoka, Toshiaki Takahashi, Miyo Shimizu, Kazuyuki Yamamoto, Sachiyo Inoue, Yuki Ohnishi, Sayoko Kobayashi, Norihiro Nakano, Yukihito Takami, Masahiro Arima, Shuji |
| description | Cryoglobulinemia can induce systemic vasculitis affecting various organs such as skin, peripheral nerves, and kidney. The disease can induce chronic organ failure and even be life‐threatening. Cryofiltration has been applied for the treatment of cryoglobulinemic vasculitis. We have experienced four cases with mixed cryoglobulinemia showing severe and progressive clinical manifestations, including skin purpura, nephrotic syndrome, acute kidney injury, and peripheral neuropathy. Cryofiltration in conjunction with conventional pharmacological therapies appeared to be safe and effective. After the treatments, plasma cryoglobulins were markedly reduced and the disease was well controlled. Although its efficacy has not yet been well established, this report can be another evidence showing efficacy of cryofiltration for treatment of mixed cryoglobulinemia. |
| doi_str_mv | 10.1111/1744-9987.12556 |
| format | Article |
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The disease can induce chronic organ failure and even be life‐threatening. Cryofiltration has been applied for the treatment of cryoglobulinemic vasculitis. We have experienced four cases with mixed cryoglobulinemia showing severe and progressive clinical manifestations, including skin purpura, nephrotic syndrome, acute kidney injury, and peripheral neuropathy. Cryofiltration in conjunction with conventional pharmacological therapies appeared to be safe and effective. After the treatments, plasma cryoglobulins were markedly reduced and the disease was well controlled. 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The disease can induce chronic organ failure and even be life‐threatening. Cryofiltration has been applied for the treatment of cryoglobulinemic vasculitis. We have experienced four cases with mixed cryoglobulinemia showing severe and progressive clinical manifestations, including skin purpura, nephrotic syndrome, acute kidney injury, and peripheral neuropathy. Cryofiltration in conjunction with conventional pharmacological therapies appeared to be safe and effective. After the treatments, plasma cryoglobulins were markedly reduced and the disease was well controlled. Although its efficacy has not yet been well established, this report can be another evidence showing efficacy of cryofiltration for treatment of mixed cryoglobulinemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Cryofiltration</subject><subject>Cryoglobulinemia</subject><subject>Cryoglobulinemia - complications</subject><subject>Cryoglobulinemia - physiopathology</subject><subject>Cryoglobulinemia - therapy</subject><subject>Cryoglobulins - metabolism</subject><subject>Disease Progression</subject><subject>Filtration - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrotic syndrome</subject><subject>Plasmapheresis - methods</subject><subject>Severity of Illness Index</subject><subject>Systemic Vasculitis - etiology</subject><subject>Systemic Vasculitis - therapy</subject><subject>Treatment Outcome</subject><subject>Vasculitis</subject><issn>1744-9979</issn><issn>1744-9987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9PwyAYQInROJ2evZkevXQDSn_gbVk2NZnRmJ68EEo_DKYdE9po_3vbde4qF8jH44U8hG4InpF-zUnKWMh5ls4IjePkBF0cJ6fHc8on6NL7T4wpZVF0jiY0SxKCeXaB3ldaGyVVF1gdLF1ntakaJxtjt4G2LsgdyKaGbTPcP5sfKPfUR2WLtjJbqI28DxbBG-ys2zNr27pgKT34K3SmZeXh-rBPUb5e5cvHcPPy8LRcbELVfyYJuaZUa02ipCA8U7qIMOaUK85LTFnMqNQSIIWMJJwnnJWK0qgEzCFLFSXRFN2N2p2zXy34RtTGK6gquQXbekE4YRnrjaxH5yOqnPXegRY7Z2rpOkGwGHqKoZgY6ol9z_7F7UHeFjWUR_4vYA_EI_BtKuj-84l88TqKfwGhKX77</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Taniyama, Yoshihiro</creator><creator>Nakatani, Yoshihisa</creator><creator>Matsuoka, Toshiaki</creator><creator>Takahashi, Miyo</creator><creator>Shimizu, Kazuyuki</creator><creator>Yamamoto, Sachiyo</creator><creator>Inoue, Yuki</creator><creator>Ohnishi, Sayoko</creator><creator>Kobayashi, Norihiro</creator><creator>Nakano, Yukihito</creator><creator>Takami, Masahiro</creator><creator>Arima, Shuji</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases</title><author>Taniyama, Yoshihiro ; 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The disease can induce chronic organ failure and even be life‐threatening. Cryofiltration has been applied for the treatment of cryoglobulinemic vasculitis. We have experienced four cases with mixed cryoglobulinemia showing severe and progressive clinical manifestations, including skin purpura, nephrotic syndrome, acute kidney injury, and peripheral neuropathy. Cryofiltration in conjunction with conventional pharmacological therapies appeared to be safe and effective. After the treatments, plasma cryoglobulins were markedly reduced and the disease was well controlled. Although its efficacy has not yet been well established, this report can be another evidence showing efficacy of cryofiltration for treatment of mixed cryoglobulinemia.</abstract><cop>Australia</cop><pmid>28661098</pmid><doi>10.1111/1744-9987.12556</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Cryofiltration Cryoglobulinemia Cryoglobulinemia - complications Cryoglobulinemia - physiopathology Cryoglobulinemia - therapy Cryoglobulins - metabolism Disease Progression Filtration - methods Humans Male Middle Aged Nephrotic syndrome Plasmapheresis - methods Severity of Illness Index Systemic Vasculitis - etiology Systemic Vasculitis - therapy Treatment Outcome Vasculitis |
| title | Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases |
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