Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch...

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Veröffentlicht in:Organic letters 2017-07, Vol.19 (14), p.3747-3750
Hauptverfasser: Huck, Lena, de la Hoz, Antonio, Díaz-Ortiz, Angel, Alcázar, Jesus
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container_end_page 3750
container_issue 14
container_start_page 3747
container_title Organic letters
container_volume 19
creator Huck, Lena
de la Hoz, Antonio
Díaz-Ortiz, Angel
Alcázar, Jesus
description An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.
doi_str_mv 10.1021/acs.orglett.7b01590
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title Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions
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