Preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma
Objectives To determine if total serum cholesterol concentrations were altered in dogs with osteosarcoma. To evaluate association of total serum cholesterol concentration with clinical outcomes in dogs with appendicular osteosarcoma. Materials and Methods Retrospective, multi‐institutional study on...
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| Veröffentlicht in: | Journal of small animal practice 2017-10, Vol.58 (10), p.562-569 |
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| creator | Leeper, H. Viall, A. Ruaux, C. Bracha, S. |
| description | Objectives
To determine if total serum cholesterol concentrations were altered in dogs with osteosarcoma. To evaluate association of total serum cholesterol concentration with clinical outcomes in dogs with appendicular osteosarcoma.
Materials and Methods
Retrospective, multi‐institutional study on 64 dogs with osteosarcoma. Control population consisted of dogs with traumatic bone fractures (n=30) and healthy patients of similar age and weight as those of the osteosarcoma cases (n=31). Survival analysis was done on 35 appendicular osteosarcoma patients that received the current standard of care. Statistical associations were assessed by univariable and multi‐variable analysis. Information about age, sex, primary tumour location, total cholesterol concentration, monocytes and lymphocyte counts and alkaline phosphatase were also included.
Results
Total cholesterol was elevated above the reference interval (3·89 to 7·12 mmol/L) (150 to 275 mg/dL) in 29 of 64 (45·3%) osteosarcoma‐bearing dogs, whereas similar elevations were found in only 3 of 30 (10%) fracture controls (P |
| doi_str_mv | 10.1111/jsap.12702 |
| format | Article |
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To determine if total serum cholesterol concentrations were altered in dogs with osteosarcoma. To evaluate association of total serum cholesterol concentration with clinical outcomes in dogs with appendicular osteosarcoma.
Materials and Methods
Retrospective, multi‐institutional study on 64 dogs with osteosarcoma. Control population consisted of dogs with traumatic bone fractures (n=30) and healthy patients of similar age and weight as those of the osteosarcoma cases (n=31). Survival analysis was done on 35 appendicular osteosarcoma patients that received the current standard of care. Statistical associations were assessed by univariable and multi‐variable analysis. Information about age, sex, primary tumour location, total cholesterol concentration, monocytes and lymphocyte counts and alkaline phosphatase were also included.
Results
Total cholesterol was elevated above the reference interval (3·89 to 7·12 mmol/L) (150 to 275 mg/dL) in 29 of 64 (45·3%) osteosarcoma‐bearing dogs, whereas similar elevations were found in only 3 of 30 (10%) fracture controls (P<0·0001) and 2 of 31 (6·5%) similar age/weight controls (P=0·0002). Elevated total cholesterol was significantly associated with a reduced hazard ratio (0·27, P=0·008) for overall mortality in dogs with osteosarcoma.
Clinical Significance
These results suggest that elevated total cholesterol is associated with canine osteosarcoma and may have prognostic significance.</description><identifier>ISSN: 0022-4510</identifier><identifier>EISSN: 1748-5827</identifier><identifier>DOI: 10.1111/jsap.12702</identifier><identifier>PMID: 28660727</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age ; Alkaline Phosphatase ; Animals ; Bone cancer ; Bone Neoplasms - blood ; Bone Neoplasms - veterinary ; Cholesterol ; Cholesterol - blood ; Dog Diseases - blood ; Dogs ; Female ; Fractures ; Low density lipoprotein ; Male ; Monocytes ; Osteosarcoma ; Osteosarcoma - blood ; Osteosarcoma - veterinary ; Retrospective Studies ; Sarcoma ; Survival analysis ; Tumors</subject><ispartof>Journal of small animal practice, 2017-10, Vol.58 (10), p.562-569</ispartof><rights>2017 British Small Animal Veterinary Association</rights><rights>2017 British Small Animal Veterinary Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3572-66befb82d6aa5f9220278776fd2c73a43d765415571e66400315f5f6cebe6e7e3</citedby><cites>FETCH-LOGICAL-c3572-66befb82d6aa5f9220278776fd2c73a43d765415571e66400315f5f6cebe6e7e3</cites><orcidid>0000-0001-9443-0682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjsap.12702$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjsap.12702$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28660727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leeper, H.</creatorcontrib><creatorcontrib>Viall, A.</creatorcontrib><creatorcontrib>Ruaux, C.</creatorcontrib><creatorcontrib>Bracha, S.</creatorcontrib><title>Preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma</title><title>Journal of small animal practice</title><addtitle>J Small Anim Pract</addtitle><description>Objectives
To determine if total serum cholesterol concentrations were altered in dogs with osteosarcoma. To evaluate association of total serum cholesterol concentration with clinical outcomes in dogs with appendicular osteosarcoma.
Materials and Methods
Retrospective, multi‐institutional study on 64 dogs with osteosarcoma. Control population consisted of dogs with traumatic bone fractures (n=30) and healthy patients of similar age and weight as those of the osteosarcoma cases (n=31). Survival analysis was done on 35 appendicular osteosarcoma patients that received the current standard of care. Statistical associations were assessed by univariable and multi‐variable analysis. Information about age, sex, primary tumour location, total cholesterol concentration, monocytes and lymphocyte counts and alkaline phosphatase were also included.
Results
Total cholesterol was elevated above the reference interval (3·89 to 7·12 mmol/L) (150 to 275 mg/dL) in 29 of 64 (45·3%) osteosarcoma‐bearing dogs, whereas similar elevations were found in only 3 of 30 (10%) fracture controls (P<0·0001) and 2 of 31 (6·5%) similar age/weight controls (P=0·0002). Elevated total cholesterol was significantly associated with a reduced hazard ratio (0·27, P=0·008) for overall mortality in dogs with osteosarcoma.
Clinical Significance
These results suggest that elevated total cholesterol is associated with canine osteosarcoma and may have prognostic significance.</description><subject>Age</subject><subject>Alkaline Phosphatase</subject><subject>Animals</subject><subject>Bone cancer</subject><subject>Bone Neoplasms - blood</subject><subject>Bone Neoplasms - veterinary</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Dog Diseases - blood</subject><subject>Dogs</subject><subject>Female</subject><subject>Fractures</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Monocytes</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - blood</subject><subject>Osteosarcoma - veterinary</subject><subject>Retrospective Studies</subject><subject>Sarcoma</subject><subject>Survival analysis</subject><subject>Tumors</subject><issn>0022-4510</issn><issn>1748-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LwzAYB_AgipvTix9AAl5E6EzSvLTHMXxl4EC9eClp-9R1tM1MWse-vdk6PXjwueQJ_Pjz8EfonJIx9XOzdHo1pkwRdoCGVPEoEBFTh2hICGMBF5QM0IlzS_-VXJFjNGCRlEQxNUTvcwtVWZeNthsMX7rqdFuaBpsCO7BdjVvT6gpnC1OBa8Eav5smg6a1O-hw2eDcfDi8LtsFNt4Yp21man2KjgpdOTjbvyP0dnf7On0IZs_3j9PJLMhCoVggZQpFGrFcai2KmDHCVKSULHKWqVDzMFdScCqEoiAlJySkohCFzCAFCQrCEbrqc1fWfHb-yqQuXQZVpRswnUtoTHnEIxErTy__0KXpbOOv84pLKmNBqFfXvcqscc5CkaxsWfuCEkqSbePJtvFk17jHF_vILq0h_6U_FXtAe7AuK9j8E5U8vUzmfeg32haL7A</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Leeper, H.</creator><creator>Viall, A.</creator><creator>Ruaux, C.</creator><creator>Bracha, S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9443-0682</orcidid></search><sort><creationdate>201710</creationdate><title>Preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma</title><author>Leeper, H. ; Viall, A. ; Ruaux, C. ; Bracha, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3572-66befb82d6aa5f9220278776fd2c73a43d765415571e66400315f5f6cebe6e7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Alkaline Phosphatase</topic><topic>Animals</topic><topic>Bone cancer</topic><topic>Bone Neoplasms - blood</topic><topic>Bone Neoplasms - veterinary</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Dog Diseases - blood</topic><topic>Dogs</topic><topic>Female</topic><topic>Fractures</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Monocytes</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - blood</topic><topic>Osteosarcoma - veterinary</topic><topic>Retrospective Studies</topic><topic>Sarcoma</topic><topic>Survival analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leeper, H.</creatorcontrib><creatorcontrib>Viall, A.</creatorcontrib><creatorcontrib>Ruaux, C.</creatorcontrib><creatorcontrib>Bracha, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of small animal practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leeper, H.</au><au>Viall, A.</au><au>Ruaux, C.</au><au>Bracha, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma</atitle><jtitle>Journal of small animal practice</jtitle><addtitle>J Small Anim Pract</addtitle><date>2017-10</date><risdate>2017</risdate><volume>58</volume><issue>10</issue><spage>562</spage><epage>569</epage><pages>562-569</pages><issn>0022-4510</issn><eissn>1748-5827</eissn><abstract>Objectives
To determine if total serum cholesterol concentrations were altered in dogs with osteosarcoma. To evaluate association of total serum cholesterol concentration with clinical outcomes in dogs with appendicular osteosarcoma.
Materials and Methods
Retrospective, multi‐institutional study on 64 dogs with osteosarcoma. Control population consisted of dogs with traumatic bone fractures (n=30) and healthy patients of similar age and weight as those of the osteosarcoma cases (n=31). Survival analysis was done on 35 appendicular osteosarcoma patients that received the current standard of care. Statistical associations were assessed by univariable and multi‐variable analysis. Information about age, sex, primary tumour location, total cholesterol concentration, monocytes and lymphocyte counts and alkaline phosphatase were also included.
Results
Total cholesterol was elevated above the reference interval (3·89 to 7·12 mmol/L) (150 to 275 mg/dL) in 29 of 64 (45·3%) osteosarcoma‐bearing dogs, whereas similar elevations were found in only 3 of 30 (10%) fracture controls (P<0·0001) and 2 of 31 (6·5%) similar age/weight controls (P=0·0002). Elevated total cholesterol was significantly associated with a reduced hazard ratio (0·27, P=0·008) for overall mortality in dogs with osteosarcoma.
Clinical Significance
These results suggest that elevated total cholesterol is associated with canine osteosarcoma and may have prognostic significance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>28660727</pmid><doi>10.1111/jsap.12702</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9443-0682</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Age Alkaline Phosphatase Animals Bone cancer Bone Neoplasms - blood Bone Neoplasms - veterinary Cholesterol Cholesterol - blood Dog Diseases - blood Dogs Female Fractures Low density lipoprotein Male Monocytes Osteosarcoma Osteosarcoma - blood Osteosarcoma - veterinary Retrospective Studies Sarcoma Survival analysis Tumors |
| title | Preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma |
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