The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis

Summary Atopic dermatitis (AD) is a chronic skin disorder characterized by pruritus and recurrent eczematous lesions that are accompanied by T‐helper (Th)2‐dominated inflammation. AD Etiology is not yet completely understood, but it is multifactorial. Moreover, the disease is characterized by comple...

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Veröffentlicht in:	Immunological reviews 2017-07, Vol.278 (1), p.246-262
Hauptverfasser:	Otsuka, Atsushi, Nomura, Takashi, Rerknimitr, Pawinee, Seidel, Judith A., Honda, Tetsuya, Kabashima, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies allergy Animals Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use Atopic dermatitis Basophils - immunology Basophils - metabolism Cytokines Cytokines - metabolism Dermatitis Dermatitis, Atopic - diagnosis Dermatitis, Atopic - etiology Dermatitis, Atopic - metabolism Dermatitis, Atopic - therapy Disease Susceptibility Environment Environmental factors Etiology Filaggrin Gene Expression Regulation Gene-Environment Interaction Genetic Predisposition to Disease Helper cells Humans Immune System - cytology Immune System - immunology Immune System - metabolism Immunity Immunity, Innate inflammation Interleukin 13 Interleukin 4 Keratinocytes Lesions Lymphocytes T Mast Cells - immunology Mast Cells - metabolism Monoclonal antibodies Pathogenesis Pruritus Receptors, Antigen, T-Cell, gamma-delta Skin Skin - immunology Skin - metabolism Skin - pathology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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