Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells

Posttranslational modifications of histones are well-established epigenetic modifications that play an important role in gene expression and regulation. These modifications are partly mediated by the Trithorax group (TrxG) complex, which regulates the induction or maintenance of gene transcription....

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Veröffentlicht in:	The Journal of immunology (1950) 2017-08, Vol.199 (3), p.1153-1162
Hauptverfasser:	Onodera, Atsushi, Kiuchi, Masahiro, Kokubo, Kota, Kato, Miki, Ogino, Tomohiro, Horiuchi, Shu, Kanai, Urara, Hirahara, Kiyoshi, Nakayama, Toshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Eosinophils - immunology Epigenesis, Genetic Epigenetics GATA-3 protein GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene expression Helper cells Histones Immune response Immunity, Cellular Immunologic Memory Immunological memory Inflammation Interleukin 1 Interleukin 13 Interleukin 4 Interleukin-13 - genetics Interleukin-13 - immunology Interleukin-4 - genetics Interleukin-4 - immunology Leukocytes (eosinophilic) Lung - immunology Lungs Lymphocytes T Mice Protein Binding Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins - metabolism Respiratory tract Respiratory tract diseases Th2 Cells - immunology Th2 Cells - metabolism Transcription Transcription, Genetic
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