Memory T Cells Expressing an NKG2D-CAR Efficiently Target Osteosarcoma Cells

NKG2D ligands (NKG2DL) are expressed on various tumor types and immunosuppressive cells within tumor microenvironments, providing suitable targets for cancer therapy. Various immune cells express NKG2D receptors, including natural killer (NK) cells and CD8 T cells. Interactions between NKG2DL and NK...

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Veröffentlicht in:	Clinical cancer research 2017-10, Vol.23 (19), p.5824-5835
Hauptverfasser:	Fernández, Lucía, Metais, Jean-Yves, Escudero, Adela, Vela, María, Valentín, Jaime, Vallcorba, Isabel, Leivas, Alejandra, Torres, Juan, Valeri, Antonio, Patiño-García, Ana, Martínez, Joaquín, Leung, Wing, Pérez-Martínez, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antitumor activity Biocompatibility Biomedical materials Bone cancer Cancer CD45RA antigen CD8 antigen Cell Line, Tumor Chimeric antigen receptors Cytolytic activity Cytometry Cytotoxicity Europium Experimental design Female Flow Cytometry Gene Expression Regulation, Neoplastic - genetics Humans Immune system Immunological memory Immunosuppression Immunotherapy Killer Cells, Natural - immunology Killer Cells, Natural - pathology Lentivirus - genetics Lymphocytes Lymphocytes T Memory cells Mice Microenvironments Natural killer cells Neoplastic Stem Cells - immunology NK Cell Lectin-Like Receptor Subfamily K - genetics NK Cell Lectin-Like Receptor Subfamily K - therapeutic use Osteosarcoma Osteosarcoma - genetics Osteosarcoma - immunology Osteosarcoma - pathology Osteosarcoma - therapy Osteosarcoma cells Receptors Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - therapeutic use Signal transduction Signal Transduction - genetics Signal Transduction - immunology Signaling Surface stability T-Lymphocytes - immunology Toxicity Transduction, Genetic Xenograft Model Antitumor Assays
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