Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1 super(-/-) mice

Hypoxia-inducible factor (HIF) transcription factors respond to multiple environmental stressors, including hypoxia and hypoglycemia. We report that mice lacking the HIF family member HIF-2 alpha (encoded by Epas1) have a syndrome of multiple-organ pathology, biochemical abnormalities and altered ge...

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Veröffentlicht in:	Nature genetics 2003-12, Vol.35 (4), p.331-340
Hauptverfasser:	Scortegagna, M, Ding, K, Oktay, Y, Gaur, A, Thurmond, F, Yan, L-J, Marck, B T, Matsumoto, A M, Shelton, J M, Richardson, JA, Bennett, MJ, Garcia, JA
Format:	Artikel
Sprache:	eng
Schlagworte:	Epas1 gene HIF-2^a protein
Online-Zugang:	Volltext
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