Effect of Methylmercury on Midbrain Cell Proliferation during Organogenesis: Potential Cross-Species Differences and Implications for Risk Assessment

5′-bromodeoxyuridine (BrdU) labeling was employed to explore the effects of methylmercury (MeHg) on cell cycle kinetics in the developing rat midbrain during gestational days (GDs) 11 to 14. Contrary to what has been previously reported in mice, no effects of MeHg on cell cycle kinetics were observe...

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Veröffentlicht in:	Toxicological sciences 2003-09, Vol.75 (1), p.124-133
Hauptverfasser:	Lewandowski, T. A., Ponce, R. A., Charleston, J. S., Hong, S., Faustman, E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cell cycle Cell Cycle - drug effects Cell Division - drug effects Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Female Flow Cytometry Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Injections, Subcutaneous interspecies Mesencephalon - drug effects Mesencephalon - embryology methylmercury Methylmercury Compounds - administration & dosage Methylmercury Compounds - toxicity Mice midbrain Organogenesis - drug effects parallelogram Pregnancy Rats Rats, Sprague-Dawley Risk Assessment Species Specificity stereology Teratology. Teratogens Time Factors
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