Efficacy and safety of sodium‐glucose cotransporter‐2 inhibitors versus dipeptidyl peptidase‐4 inhibitors as monotherapy or add‐on to metformin in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

Aims To compare the efficacy and safety of dipeptidyl peptidase‐4 inhibitors (DPP‐4is) and sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2is) as monotherapy or add‐on to metformin (Met) in patients with type 2 diabetes mellitus (T2DM). Materials and Methods PubMed, Embase and ClinicalTrials.gov si...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2018-01, Vol.20 (1), p.113-120
Hauptverfasser:	Wang, Zhiying, Sun, Jiahui, Han, Ruobing, Fan, Dongzhu, Dong, Xinyi, Luan, Zenghui, Xiang, Rongwu, Zhao, Mingyi, Yang, Jingyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Obesity Agents - adverse effects Anti-Obesity Agents - therapeutic use Antidiabetics Body weight Clinical trials Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy dipeptidyl peptidase‐4 inhibitors Dipeptidyl-peptidase IV Dipeptidyl-Peptidase IV Inhibitors - adverse effects Dipeptidyl-Peptidase IV Inhibitors - therapeutic use Drug Resistance Drug Therapy, Combination - adverse effects Evidence-based medicine Glucose Glycated Hemoglobin A - analysis Hemoglobin Humans Hyperglycemia - prevention & control Hypoglycemia Hypoglycemia - chemically induced Hypoglycemia - prevention & control Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Membrane Transport Modulators - adverse effects Membrane Transport Modulators - therapeutic use Meta-analysis Metformin Metformin - therapeutic use Overweight - complications Overweight - drug therapy Overweight - prevention & control Peptidase Randomized Controlled Trials as Topic Safety Sodium Sodium-glucose cotransporter Sodium-Glucose Transporter 2 - antagonists & inhibitors Sodium-Glucose Transporter 2 - metabolism sodium‐glucose cotransporter‐2 inhibitors Systematic review type 2 diabetes mellitus Weight Loss - drug effects
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