MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk
Assess the dosimetric impact of multi-leaf collimator (MLC) tracking and mid-ventilation (midV) planning compared with the internal target volume (ITV)-based planning approach for lung Stereotactic Ablative Body Radiotherapy (SABR). Ten lung SABR patients originally treated with an ITV-based plan we...
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| Veröffentlicht in: | Radiotherapy and oncology 2017-07, Vol.124 (1), p.18-24 |
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| creator | Caillet, Vincent Keall, Paul J. Colvill, Emma Hardcastle, Nicholas O'Brien, Ricky Szymura, Kathryn Booth, Jeremy T. |
| description | Assess the dosimetric impact of multi-leaf collimator (MLC) tracking and mid-ventilation (midV) planning compared with the internal target volume (ITV)-based planning approach for lung Stereotactic Ablative Body Radiotherapy (SABR).
Ten lung SABR patients originally treated with an ITV-based plan were re-planned according to MLC tracking and midV planning schemes. All plans were delivered on a linac to a motion phantom in a simulated treatment with real lung motions. Delivered dose was reconstructed in patient planning scans. ITV-based, tracking and midV regimes were compared at the planning and delivered stages based on PTV volume and dose metrics for the GTV and OAR.
MLC tracking and midV schemes yielded favourable outcomes compared with ITV-based plans. Average reduction in PTV volume was (MLC tracking/MidV) 33.9%/22%. GTV dose coverage performed better with MLC tracking than the other regimes. Reduction in dose to OAR were for the lung (mean lung dose, 0.8Gy/0.2Gy), oesophagus (D3cc, 1.9Gy/1.4Gy), great vessels (D10cc, 3.2Gy/1.3Gy), trachea (D4cc, 1.1Gy/0.9Gy), heart (D1cc, 2.0Gy/0.5Gy) and spinal cord (D0.03cc, 0.5Gy/−0.1Gy).
MLC tracking showed reduction in PTV volume, superior GTV dose coverage and organ dose sparing than MidV and ITV-based strategies. |
| doi_str_mv | 10.1016/j.radonc.2017.06.016 |
| format | Article |
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Ten lung SABR patients originally treated with an ITV-based plan were re-planned according to MLC tracking and midV planning schemes. All plans were delivered on a linac to a motion phantom in a simulated treatment with real lung motions. Delivered dose was reconstructed in patient planning scans. ITV-based, tracking and midV regimes were compared at the planning and delivered stages based on PTV volume and dose metrics for the GTV and OAR.
MLC tracking and midV schemes yielded favourable outcomes compared with ITV-based plans. Average reduction in PTV volume was (MLC tracking/MidV) 33.9%/22%. GTV dose coverage performed better with MLC tracking than the other regimes. Reduction in dose to OAR were for the lung (mean lung dose, 0.8Gy/0.2Gy), oesophagus (D3cc, 1.9Gy/1.4Gy), great vessels (D10cc, 3.2Gy/1.3Gy), trachea (D4cc, 1.1Gy/0.9Gy), heart (D1cc, 2.0Gy/0.5Gy) and spinal cord (D0.03cc, 0.5Gy/−0.1Gy).
MLC tracking showed reduction in PTV volume, superior GTV dose coverage and organ dose sparing than MidV and ITV-based strategies.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2017.06.016</identifier><identifier>PMID: 28655454</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy ; Dose-Response Relationship, Radiation ; Humans ; Lung cancer ; Lung Neoplasms - radiotherapy ; MLC tracking ; Organs at Risk - radiation effects ; Particle Accelerators - instrumentation ; Phantoms, Imaging ; Radiation pneumonitis ; Radiosurgery - adverse effects ; Radiosurgery - methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - instrumentation ; Radiotherapy Planning, Computer-Assisted - methods ; Real time adaptive radiotherapy ; Respiratory Mechanics</subject><ispartof>Radiotherapy and oncology, 2017-07, Vol.124 (1), p.18-24</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-2dbba995b89fec60b5263e4969f2f8b4a4e8d123e278bc0ab05b1b2f83defea03</citedby><cites>FETCH-LOGICAL-c408t-2dbba995b89fec60b5263e4969f2f8b4a4e8d123e278bc0ab05b1b2f83defea03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167814017304231$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28655454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caillet, Vincent</creatorcontrib><creatorcontrib>Keall, Paul J.</creatorcontrib><creatorcontrib>Colvill, Emma</creatorcontrib><creatorcontrib>Hardcastle, Nicholas</creatorcontrib><creatorcontrib>O'Brien, Ricky</creatorcontrib><creatorcontrib>Szymura, Kathryn</creatorcontrib><creatorcontrib>Booth, Jeremy T.</creatorcontrib><title>MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>Assess the dosimetric impact of multi-leaf collimator (MLC) tracking and mid-ventilation (midV) planning compared with the internal target volume (ITV)-based planning approach for lung Stereotactic Ablative Body Radiotherapy (SABR).
Ten lung SABR patients originally treated with an ITV-based plan were re-planned according to MLC tracking and midV planning schemes. All plans were delivered on a linac to a motion phantom in a simulated treatment with real lung motions. Delivered dose was reconstructed in patient planning scans. ITV-based, tracking and midV regimes were compared at the planning and delivered stages based on PTV volume and dose metrics for the GTV and OAR.
MLC tracking and midV schemes yielded favourable outcomes compared with ITV-based plans. Average reduction in PTV volume was (MLC tracking/MidV) 33.9%/22%. GTV dose coverage performed better with MLC tracking than the other regimes. Reduction in dose to OAR were for the lung (mean lung dose, 0.8Gy/0.2Gy), oesophagus (D3cc, 1.9Gy/1.4Gy), great vessels (D10cc, 3.2Gy/1.3Gy), trachea (D4cc, 1.1Gy/0.9Gy), heart (D1cc, 2.0Gy/0.5Gy) and spinal cord (D0.03cc, 0.5Gy/−0.1Gy).
MLC tracking showed reduction in PTV volume, superior GTV dose coverage and organ dose sparing than MidV and ITV-based strategies.</description><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>MLC tracking</subject><subject>Organs at Risk - radiation effects</subject><subject>Particle Accelerators - instrumentation</subject><subject>Phantoms, Imaging</subject><subject>Radiation pneumonitis</subject><subject>Radiosurgery - adverse effects</subject><subject>Radiosurgery - methods</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - instrumentation</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Real time adaptive radiotherapy</subject><subject>Respiratory Mechanics</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi0EgrK8AUI-ckkYJ07iXJCgYpOKkICeLS-TKiWNi50g8fa4auHIaUbf_LP9hJwzSBmw8mqZemVdb9IMWJVCmUa4RyZMVHUCQlT7ZBJJlQjG4Ygch7AEgAzy6pAcZaIsCl7wCZk_z6Z08Mp8tP2CNs7TbozJ283tK_VoR4OBrjvV95vyoPwCB_rlunEVueottS4gHRx1fqH6iAbq2_BxSg4a1QU828UTMr-_e58-JrOXh6fpzSwxHMSQZFZrVdeFFnWDpgRdZGWOvC7rJmuE5oqjsCzLMauENqA0FJrpWMotNqggPyGX27lr7z5HDINctcFgFw9GNwbJasaLqi7FRsq3UuNdCB4bufbtSvlvyUBuDJVLuTVUbgyVUMoIY9vFbsOoV2j_mn4djILrrQDjn18tehlMi71B23o0g7Su_X_DD663iPc</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Caillet, Vincent</creator><creator>Keall, Paul J.</creator><creator>Colvill, Emma</creator><creator>Hardcastle, Nicholas</creator><creator>O'Brien, Ricky</creator><creator>Szymura, Kathryn</creator><creator>Booth, Jeremy T.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk</title><author>Caillet, Vincent ; Keall, Paul J. ; Colvill, Emma ; Hardcastle, Nicholas ; O'Brien, Ricky ; Szymura, Kathryn ; Booth, Jeremy T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-2dbba995b89fec60b5263e4969f2f8b4a4e8d123e278bc0ab05b1b2f83defea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Carcinoma, Non-Small-Cell Lung - radiotherapy</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>MLC tracking</topic><topic>Organs at Risk - radiation effects</topic><topic>Particle Accelerators - instrumentation</topic><topic>Phantoms, Imaging</topic><topic>Radiation pneumonitis</topic><topic>Radiosurgery - adverse effects</topic><topic>Radiosurgery - methods</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - instrumentation</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Real time adaptive radiotherapy</topic><topic>Respiratory Mechanics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caillet, Vincent</creatorcontrib><creatorcontrib>Keall, Paul J.</creatorcontrib><creatorcontrib>Colvill, Emma</creatorcontrib><creatorcontrib>Hardcastle, Nicholas</creatorcontrib><creatorcontrib>O'Brien, Ricky</creatorcontrib><creatorcontrib>Szymura, Kathryn</creatorcontrib><creatorcontrib>Booth, Jeremy T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caillet, Vincent</au><au>Keall, Paul J.</au><au>Colvill, Emma</au><au>Hardcastle, Nicholas</au><au>O'Brien, Ricky</au><au>Szymura, Kathryn</au><au>Booth, Jeremy T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2017-07</date><risdate>2017</risdate><volume>124</volume><issue>1</issue><spage>18</spage><epage>24</epage><pages>18-24</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Assess the dosimetric impact of multi-leaf collimator (MLC) tracking and mid-ventilation (midV) planning compared with the internal target volume (ITV)-based planning approach for lung Stereotactic Ablative Body Radiotherapy (SABR).
Ten lung SABR patients originally treated with an ITV-based plan were re-planned according to MLC tracking and midV planning schemes. All plans were delivered on a linac to a motion phantom in a simulated treatment with real lung motions. Delivered dose was reconstructed in patient planning scans. ITV-based, tracking and midV regimes were compared at the planning and delivered stages based on PTV volume and dose metrics for the GTV and OAR.
MLC tracking and midV schemes yielded favourable outcomes compared with ITV-based plans. Average reduction in PTV volume was (MLC tracking/MidV) 33.9%/22%. GTV dose coverage performed better with MLC tracking than the other regimes. Reduction in dose to OAR were for the lung (mean lung dose, 0.8Gy/0.2Gy), oesophagus (D3cc, 1.9Gy/1.4Gy), great vessels (D10cc, 3.2Gy/1.3Gy), trachea (D4cc, 1.1Gy/0.9Gy), heart (D1cc, 2.0Gy/0.5Gy) and spinal cord (D0.03cc, 0.5Gy/−0.1Gy).
MLC tracking showed reduction in PTV volume, superior GTV dose coverage and organ dose sparing than MidV and ITV-based strategies.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28655454</pmid><doi>10.1016/j.radonc.2017.06.016</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Carcinoma, Non-Small-Cell Lung - radiotherapy Dose-Response Relationship, Radiation Humans Lung cancer Lung Neoplasms - radiotherapy MLC tracking Organs at Risk - radiation effects Particle Accelerators - instrumentation Phantoms, Imaging Radiation pneumonitis Radiosurgery - adverse effects Radiosurgery - methods Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - instrumentation Radiotherapy Planning, Computer-Assisted - methods Real time adaptive radiotherapy Respiratory Mechanics |
| title | MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk |
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